Title:
PHARMACEUTICAL USE OF HYPOXIA-INDUCIBLE LIPID DROPLET-ASSOCIATED PROTEIN OR TRUNCATED FRAGMENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/237548
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine, and relates to a pharmaceutical use of a hypoxia-inducible lipid droplet-associated protein or a truncated fragment thereof. Specifically, the present invention relates to a use of a hypoxia-inducible lipid droplet-associated protein or a truncated active fragment thereof in the preparation of a drug for treating or preventing hyperlipidemia, hyperlipidemia complications or neurodegenerative diseases, or a use of the hypoxia-inducible lipid droplet-associated protein or the truncated active fragment thereof in the preparation of a drug for reducing the apolipoprotein level, low density lipoprotein level, or very low density lipoprotein level in blood or cerebrospinal fluid.
Inventors:
ZOU YILONG (CN)
SHI TAOTAO (CN)
WU TIANSHU (CN)
WANG FENGXIANG (CN)
LU YANG (CN)
PAN ZIJIAN (CN)
HAN JINGRONG (CN)
PENG QIN (CN)
WANG YIXIN (CN)
SHI TAOTAO (CN)
WU TIANSHU (CN)
WANG FENGXIANG (CN)
LU YANG (CN)
PAN ZIJIAN (CN)
HAN JINGRONG (CN)
PENG QIN (CN)
WANG YIXIN (CN)
Application Number:
PCT/CN2022/089740
Publication Date:
November 17, 2022
Filing Date:
April 28, 2022
Export Citation:
Assignee:
UNIV WESTLAKE (CN)
International Classes:
A61K38/17; A61P3/06; A61P25/00; A61P25/16; A61P25/28
Foreign References:
| CN107607725A | 2018-01-19 | |||
| CN104958753A | 2015-10-07 | |||
| US20200397828A1 | 2020-12-24 | |||
| US20200017440A1 | 2020-01-16 | |||
| US20150366997A1 | 2015-12-24 | |||
| US20160287622A1 | 2016-10-06 | |||
| US20150157565A1 | 2015-06-11 | |||
| US20180125989A1 | 2018-05-10 |
Other References:
PADMANABHA DAS KRISHNA M., WECHSELBERGER LISA, LIZICZAI MÁRTON, DE LA ROSA RODRIGUEZ MONTSERRAT, GRABNER GERNOT F., HEIER CHRISTOP: "Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase", JOURNAL OF LIPID RESEARCH, vol. 59, no. 3, 1 March 2018 (2018-03-01), US , pages 531 - 541, XP093003121, ISSN: 0022-2275, DOI: 10.1194/jlr.M082388
CANCER RES, vol. 65, no. 11, 1 June 2005 (2005-06-01), pages 4817 - 26
FASEB J, vol. 24, no. 11, November 2010 (2010-11-01), pages 4443 - 58
J. SAMBROOK ET AL.: "Molecular Cloning Experiment Guide", SCIENCE PRESS
CANCER RES, vol. 65, no. 11, 1 June 2005 (2005-06-01), pages 4817 - 26
FASEB J, vol. 24, no. 11, November 2010 (2010-11-01), pages 4443 - 58
J. SAMBROOK ET AL.: "Molecular Cloning Experiment Guide", SCIENCE PRESS
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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