Title:
PHARMACEUTICAL USE OF CDK4/6 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/040914
Kind Code:
A1
Abstract:
Disclosed are a method for treating cancer with a CDK4/6 inhibitor and a corresponding pharmaceutical use. The CDK4/6 inhibitor is 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1, 3'-indole]-5'-yl)-nitrogen-(5-(1-methylpiperidin-4-yl)pyridin-2-yl)pyrimidin-2-amine, and said cancer comprises colorectal cancer, liver cancer, or breast cancer. The CDK4/6 inhibitor has a good tumor suppression effect.
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Inventors:
YIN LEI (CN)
YAO ZHENGLIN (CN)
YAO ZHENGLIN (CN)
Application Number:
PCT/CN2022/118817
Publication Date:
March 23, 2023
Filing Date:
September 14, 2022
Export Citation:
Assignee:
GAN & LEE PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/506; A61P35/00; C07D401/14; C07D471/04
Foreign References:
| CN106810536A | 2017-06-09 | |||
| CN106608879A | 2017-05-03 | |||
| CN102264725A | 2011-11-30 | |||
| CN101001857A | 2007-07-18 |
Other References:
LEI YIN, HENG LI, WENJIAN LIU, ZHENGLIN YAO, ZHENZHEN CHENG, HUABEI ZHANG, HUI ZOU: "A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy", EUROEPAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, pages 1 - 28, XP055766971, [retrieved on 20210120]
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