Title:
PHARMACEUTICAL USES OF BISPHOSPHONATES
Document Type and Number:
WIPO Patent Application WO2005053709
Kind Code:
A3
Abstract:
A method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a chemotherapeutica agent selected from the group consisting of: taxol, a derivative thereof and letrozole, followed sequentially by an effective amount of a bisphosphonate. The invention further provides a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonate followed sequentially by an effective amount of TRAIL.
More Like This:
Inventors:
COLEMAN ROBERT EDWARD (GB)
HOLEN INGUNN (GB)
NEVILLE-WEBBE HELEN (GB)
EVANS CATHERINE ALYSON (GB)
HOLEN INGUNN (GB)
NEVILLE-WEBBE HELEN (GB)
EVANS CATHERINE ALYSON (GB)
Application Number:
PCT/EP2004/013728
Publication Date:
January 05, 2006
Filing Date:
December 02, 2004
Export Citation:
Assignee:
UNIV SHEFFIELD (GB)
COLEMAN ROBERT EDWARD (GB)
HOLEN INGUNN (GB)
NEVILLE-WEBBE HELEN (GB)
EVANS CATHERINE ALYSON (GB)
COLEMAN ROBERT EDWARD (GB)
HOLEN INGUNN (GB)
NEVILLE-WEBBE HELEN (GB)
EVANS CATHERINE ALYSON (GB)
International Classes:
A61K31/337; A61K31/4196; A61K31/663; (IPC1-7): A61K31/663; A61K31/337; A61K31/4196; A61P35/00
Domestic Patent References:
| WO2003035081A1 | 2003-05-01 | |||
| WO2004012728A1 | 2004-02-12 |
Other References:
ALGUR E ET AL: "Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines", INTERNATIONAL JOURNAL OF RADIATION: ONCOLOGY BIOLOGY PHYSICS, PERGAMON PRESS, US, vol. 61, no. 2, 1 February 2005 (2005-02-01), pages 535 - 542, XP004749602, ISSN: 0360-3016
JAGDEV S P ET AL: "THE BISPHOSPHONATE, ZOLEDRONIC ACID, INDUCES APOPTOSIS OF BREAST CANCER CELLS: EVIDENCE FOR SYNERGY WITH PACLITAXEL", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 8, no. 84, 2001, pages 1126 - 1134, XP008001603, ISSN: 0007-0920
KOKUFU I ET AL: "[A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer]", GAN TO KAGAKU RYOHO. CANCER & CHEMOTHERAPY. AUG 2000, vol. 27, no. 9, August 2000 (2000-08-01), pages 1425 - 1428, XP002345936, ISSN: 0385-0684
HARVEY H A: "ISSUES CONCERNING THE ROLE OF CHEMOTHERAPY AND HORMONAL THERAPY OF BONE METASTASES FROM BREAST CARCINOMA", CANCER, AMERICAN CANCER SOCIETY, PHILADELPHIA, PA, US, vol. 80, no. 8, SUPPL, 1997, pages 1646 - 1651, XP000929334, ISSN: 0008-543X
HARVEY H A: "Therapeutic use of bisphosphonates in breast cancer: Studies with zoledronic acid", AMERICAN JOURNAL OF CANCER 2003 NEW ZEALAND, vol. 2, no. SUPPL., 2003, pages 19 - 25, XP009054127, ISSN: 1175-6357
FREYER G ET AL: "Palliative hormone therapy, low dose chemotherapy and bisphosphonate in breast cancer patients with bone marrow involvement and pancytopenia; report of pilot experience", EUROPEAN JOURNAL OF INTERNAL MEDICINE, ELSEVIER, AMSTERDAM,, NL, vol. 11, 2000, pages 329 - 333, XP002257266, ISSN: 0953-6205
NEVILLE-WEBBE HL, EVANS CA, COLEMAN RE, HOLEN I: "THE COMBINATION OF ZOLEDRONIC ACID (ZOL) AND TRAIL (TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND) HAS POTENTIAL SYNERGISTIC ACTION IN BREAST CANCER CELLS (BCC)", CLINICAL ONCOLOGY, vol. 15, September 2003 (2003-09-01), pages S28 - S29, XP009054117
JAGDEV S P ET AL: "THE BISPHOSPHONATE, ZOLEDRONIC ACID, INDUCES APOPTOSIS OF BREAST CANCER CELLS: EVIDENCE FOR SYNERGY WITH PACLITAXEL", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 8, no. 84, 2001, pages 1126 - 1134, XP008001603, ISSN: 0007-0920
KOKUFU I ET AL: "[A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer]", GAN TO KAGAKU RYOHO. CANCER & CHEMOTHERAPY. AUG 2000, vol. 27, no. 9, August 2000 (2000-08-01), pages 1425 - 1428, XP002345936, ISSN: 0385-0684
HARVEY H A: "ISSUES CONCERNING THE ROLE OF CHEMOTHERAPY AND HORMONAL THERAPY OF BONE METASTASES FROM BREAST CARCINOMA", CANCER, AMERICAN CANCER SOCIETY, PHILADELPHIA, PA, US, vol. 80, no. 8, SUPPL, 1997, pages 1646 - 1651, XP000929334, ISSN: 0008-543X
HARVEY H A: "Therapeutic use of bisphosphonates in breast cancer: Studies with zoledronic acid", AMERICAN JOURNAL OF CANCER 2003 NEW ZEALAND, vol. 2, no. SUPPL., 2003, pages 19 - 25, XP009054127, ISSN: 1175-6357
FREYER G ET AL: "Palliative hormone therapy, low dose chemotherapy and bisphosphonate in breast cancer patients with bone marrow involvement and pancytopenia; report of pilot experience", EUROPEAN JOURNAL OF INTERNAL MEDICINE, ELSEVIER, AMSTERDAM,, NL, vol. 11, 2000, pages 329 - 333, XP002257266, ISSN: 0953-6205
NEVILLE-WEBBE HL, EVANS CA, COLEMAN RE, HOLEN I: "THE COMBINATION OF ZOLEDRONIC ACID (ZOL) AND TRAIL (TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND) HAS POTENTIAL SYNERGISTIC ACTION IN BREAST CANCER CELLS (BCC)", CLINICAL ONCOLOGY, vol. 15, September 2003 (2003-09-01), pages S28 - S29, XP009054117
Download PDF:
Previous Patent: LOTEPREDNOL ETABONATE WATER BASE SUSPENSION FORMULATION
Next Patent: FOOD COMPOSITION COMPRISING GLUCOSAMINE
Next Patent: FOOD COMPOSITION COMPRISING GLUCOSAMINE