PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF

Title:

PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2003043979

Kind Code:

A3

Abstract:

The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.

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Inventors:

ROSOWSKY ANDRE (US)
FORSCH RONALD A (US)

Application Number:

PCT/US2002/037155

Publication Date:

July 17, 2003

Filing Date:

November 19, 2002

Export Citation:

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Assignee:

DANA FARBER CANCER INST INC (US)
ROSOWSKY ANDRE (US)
FORSCH RONALD A (US)

International Classes:

A61P31/04; A61P31/18; A61P33/08; C07D239/48; C07D239/49; C07D239/95; C07D471/04; (IPC1-7): C07D239/49; A61K31/505; A61K31/519; A61P31/04; A61P31/18; A61P33/08; C07D487/04

Foreign References:

US3715357A	1973-02-06
US5736547A	1998-04-07

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