Title:
PHARMACOKINETIC ANALYSIS METHOD, PHARMACOKINETIC ANALYSIS DEVICE, AND PROGRAM
Document Type and Number:
WIPO Patent Application WO/2018/012246
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a pharmacokinetic analysis method and the like, whereby a pharmacokinetic change in a patient can be easily analyzed in response to a change in a physiological function of the patient. An individual pharmacokinetics calculation unit 21 calculates an individual pharmacokinetic value of a patient by using an entered physiological function of the patient and a mathematical model, and a population pharmacokinetics acquisition unit 25 obtains a population pharmacokinetic value of a population to which the patient belongs. A variation coefficient calculation unit 29 calculates a variation coefficient from the individual pharmacokinetic value and the population pharmacokinetic value. A change-in-population-pharmacokinetics acquisition unit 41 obtains a change in the average pharmacokinetic value of the population in response to the change in the entered physiological function. A change-in-patient-pharmacokinetics calculation unit 45 obtains, by taking advantage of the fact that the variation coefficient remains constant even when the physiological function has changed, a change in the individual pharmacokinetic value of the patient by using the change in the average pharmacokinetic value of the population and the variation coefficient.
Inventors:
ODA KAZUTAKA (JP)
JONO HIROFUMI (JP)
SAITO HIDEYUKI (JP)
JONO HIROFUMI (JP)
SAITO HIDEYUKI (JP)
Application Number:
PCT/JP2017/023151
Publication Date:
January 18, 2018
Filing Date:
June 23, 2017
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
G01N33/49
Foreign References:
| JP2004510961A | 2004-04-08 | |||
| JP2002267756A | 2002-09-18 | |||
| JP2007526051A | 2007-09-13 | |||
| JP2014500100A | 2014-01-09 |
Other References:
TAKAHITO TANIGAWA ET AL.: "Iyakuhin kaihatsu tool to shiteno boshudan PK-PD kaiseki", 1 ST EDITION, ASAKURA PUBLISHING CO. LTD., 10 September 2010 (2010-09-10), Kunizo ASAKURA, pages 21-23 - 89-96, ISBN: 978-4-254-34026-6
KAZUTAKA ODA: "Development of Software for antimicrobial PK/PD Simulation Incorporating Montecarlo Simulation based on Microsoft Office Excel", IRIYO YAKUGAKU, vol. 37, no. 6, 2011, pages 335 - 344, ISSN: 1346-342X
KAZUTAKA ODA: "Development of Software for antimicrobial PK/PD Simulation Incorporating Montecarlo Simulation based on Microsoft Office Excel", IRIYO YAKUGAKU, vol. 37, no. 6, 2011, pages 335 - 344, ISSN: 1346-342X
Attorney, Agent or Firm:
HADATE Koji (JP)
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