Title:
PHARMACOKINETIC EVALUATION METHOD AND KIT FOR PHARMACOKINETIC EVALUATION
Document Type and Number:
WIPO Patent Application WO/2014/057699
Kind Code:
A1
Abstract:
The problem of the present invention is to provide a pharmacokinetic evaluation method and kit for pharmacokinetic evaluation with which accurate pharmacokinetic evaluation can be performed in one measurement without using a radioactive substance. The problem is solved by a pharmacokinetic evaluation method and kit for pharmacokinetic evaluation with which pharmacokinetic data is obtained from changes over time in the blood concentration in a blood sample collected from a subject following extravascular administration of a compound followed by intravenous administration of the stable isotope substitute of the compound.
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Inventors:
YAMASHITA SHINJI (JP)
MASAOKA YOSHIE (JP)
TOGASHI KAZUTAKA (JP)
MASAOKA YOSHIE (JP)
TOGASHI KAZUTAKA (JP)
Application Number:
PCT/JP2013/060904
Publication Date:
April 17, 2014
Filing Date:
April 11, 2013
Export Citation:
Assignee:
SUMIKA CHEM ANALYSIS SERVICES (JP)
International Classes:
G01N33/50; G01N33/15; G01N33/49
Foreign References:
| JP2002541220A | 2002-12-03 |
Other References:
JORN M. STRONG: "Absolute bioavailability in man of N-acetylprocainamide determined by a novel stable isotope method", CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 18, 8 November 1975 (1975-11-08), pages 613 - 622
A. BARRISH: "The Use of Stable Isotope Labeling and Liquid Chromatography/Tandem Mass Spectrometry Techniques to Study the Pharmacokinetics and Bioavailability of the Antimigraine Drug", MK-0462 (RIZATRIPTAN) IN DOGS, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 10, no. ISS.9, 1996, pages 1033 - 1037
A. BARRISH: "The Use of Stable Isotope Labeling and Liquid Chromatography/Tandem Mass Spectrometry Techniques to Study the Pharmacokinetics and Bioavailability of the Antimigraine Drug", MK-0462 (RIZATRIPTAN) IN DOGS, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 10, no. ISS.9, 1996, pages 1033 - 1037
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
Patent business corporation Hara [Kenzo] international patent firm (JP)
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