Title:
PHENALENE-1-ONE DERIVATIVES, METHOD FOR PRODUCING SAME AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/113860
Kind Code:
A3
Abstract:
The invention relates to a compound of formula (1): where R1 through R8, which can be identical or different from each other, each are selected from of the group comprising hydrogen and the radical -(CH2)k-X, where k is a whole number from 1 to 20 and where X is an organic radical comprising a) at least one neutral, protonizable nitrogen atom and/or b) at least one positively charged nitrogen atom, under the provision that at least 1 radical R1 through R8 is not hydrogen. The invention further relates to the production and use of said compound.
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Inventors:
BAEUMLER WOLFGANG (DE)
FELGENTRAEGER ARIANE (DE)
LEHNER KARIN (DE)
MAISCH TIM (DE)
REGENSBURGER JOHANNES (DE)
SANTARELLI FRANCESCO (DE)
SPAETH ANDREAS (DE)
FELGENTRAEGER ARIANE (DE)
LEHNER KARIN (DE)
MAISCH TIM (DE)
REGENSBURGER JOHANNES (DE)
SANTARELLI FRANCESCO (DE)
SPAETH ANDREAS (DE)
Application Number:
PCT/EP2012/053062
Publication Date:
October 18, 2012
Filing Date:
February 23, 2012
Export Citation:
Assignee:
TRIOPTOTEC GMBH (DE)
BAEUMLER WOLFGANG (DE)
FELGENTRAEGER ARIANE (DE)
LEHNER KARIN (DE)
MAISCH TIM (DE)
REGENSBURGER JOHANNES (DE)
SANTARELLI FRANCESCO (DE)
SPAETH ANDREAS (DE)
BAEUMLER WOLFGANG (DE)
FELGENTRAEGER ARIANE (DE)
LEHNER KARIN (DE)
MAISCH TIM (DE)
REGENSBURGER JOHANNES (DE)
SANTARELLI FRANCESCO (DE)
SPAETH ANDREAS (DE)
International Classes:
A61L2/16; A61K41/00; C07C213/00; C07C217/10; C07C221/00; C07C223/02; C07C269/06; C07C271/16; C07C277/08; C07C279/02; C07C279/24; C07D211/56; C07D213/20; C07D213/73; C07D295/04
Foreign References:
| US20070110672A1 | 2007-05-17 | |||
| EP0341018A1 | 1989-11-08 | |||
| GB2337530A | 1999-11-24 | |||
| DE2224371A1 | 1973-01-11 |
Other References:
CRISTINA FLORS ET AL: "Light and Singlet Oxygen in Plant Defense Against Pathogens: Phototoxic Phenalenone Phytoalexins +", ACCOUNTS OF CHEMICAL RESEARCH, vol. 39, no. 5, 1 May 2006 (2006-05-01), pages 293 - 300, XP055035752, ISSN: 0001-4842, DOI: 10.1021/ar0402863
NASSER K. THALLAJ ET AL: "The Design of Metal Chelates with a Biologically Related Redox-Active Part: Conjugation of Riboflavin to Bis(2-pyridylmethyl)amine Ligand and Preparation of a Ferric Complex", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 2007, no. 1, 1 January 2007 (2007-01-01), pages 44 - 47, XP055034009, ISSN: 1434-1948, DOI: 10.1002/ejic.200600789
MICHAEL R. DETTY ET AL: "Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 16, 1 July 2004 (2004-07-01), pages 3897 - 3915, XP055034032, ISSN: 0022-2623, DOI: 10.1021/jm040074b
ESTHER OLIVEROS ET AL: "Photochemistry of the singlet oxygen [O2(1[Delta]g)] sensitizer perinaphthenone (phenalenone) in N,N'-dimethylacetamide and 1,4-dioxane", NEW JOURNAL OF CHEMISTRY, vol. 23, no. 1, 1 January 1999 (1999-01-01), pages 85 - 93, XP055035753, ISSN: 1144-0546, DOI: 10.1039/a804054k
NASSER K. THALLAJ ET AL: "The Design of Metal Chelates with a Biologically Related Redox-Active Part: Conjugation of Riboflavin to Bis(2-pyridylmethyl)amine Ligand and Preparation of a Ferric Complex", EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, vol. 2007, no. 1, 1 January 2007 (2007-01-01), pages 44 - 47, XP055034009, ISSN: 1434-1948, DOI: 10.1002/ejic.200600789
MICHAEL R. DETTY ET AL: "Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, no. 16, 1 July 2004 (2004-07-01), pages 3897 - 3915, XP055034032, ISSN: 0022-2623, DOI: 10.1021/jm040074b
ESTHER OLIVEROS ET AL: "Photochemistry of the singlet oxygen [O2(1[Delta]g)] sensitizer perinaphthenone (phenalenone) in N,N'-dimethylacetamide and 1,4-dioxane", NEW JOURNAL OF CHEMISTRY, vol. 23, no. 1, 1 January 1999 (1999-01-01), pages 85 - 93, XP055035753, ISSN: 1144-0546, DOI: 10.1039/a804054k
Attorney, Agent or Firm:
WALCHER, Armin (Zusammenschluss Nr. 39Postfach 30 55, Nürnberg, DE)
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