Title:
PHENALENONES AS ANTITUMORAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2011/009899
Kind Code:
A3
Abstract:
Compounds of general formula (Ia) or (Ib) or (Ic) or (Id), wherein the R groups are each independently selected from the group consisting of hydrogen, acyl, alkyl, alkenyl, alkynyl, aryl, -CONH2, alkali metal, and sugar, and their use for the treatment of cancers.
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Inventors:
SANCHEZ LOPEZ JOSE MARIA (ES)
MARTINEZ INSUA MARTA (ES)
VINUESA-NAVARRO MARIA DE LOS ANGELES (ES)
DE LA FUENTE BLANCO JESUS ANGEL (ES)
FERNANDEZ-MEDARDE ANTONIO (ES)
MARTINEZ INSUA MARTA (ES)
VINUESA-NAVARRO MARIA DE LOS ANGELES (ES)
DE LA FUENTE BLANCO JESUS ANGEL (ES)
FERNANDEZ-MEDARDE ANTONIO (ES)
Application Number:
PCT/EP2010/060588
Publication Date:
September 22, 2011
Filing Date:
July 21, 2010
Export Citation:
Assignee:
INST BIOMAR SA (ES)
SANCHEZ LOPEZ JOSE MARIA (ES)
MARTINEZ INSUA MARTA (ES)
VINUESA-NAVARRO MARIA DE LOS ANGELES (ES)
DE LA FUENTE BLANCO JESUS ANGEL (ES)
FERNANDEZ-MEDARDE ANTONIO (ES)
SANCHEZ LOPEZ JOSE MARIA (ES)
MARTINEZ INSUA MARTA (ES)
VINUESA-NAVARRO MARIA DE LOS ANGELES (ES)
DE LA FUENTE BLANCO JESUS ANGEL (ES)
FERNANDEZ-MEDARDE ANTONIO (ES)
International Classes:
C07C49/743; A61K31/122; A61K31/22; A61K31/27; A61K31/423; A61P35/00; C07C69/007; C07C271/12; C07D263/52; C12P15/00; C12P17/14
Domestic Patent References:
| WO2003068946A1 | 2003-08-21 |
Other References:
YAMADA, K. ET AL.: "Sinulobatins A ~ D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata", TETRAHEDRON, vol. 53, no. 13, 1997, pages 4569 - 4578, XP004771878, ISSN: 0040-4020, DOI: DOI:10.1016/S0040-4020(97)00169-5
MITOME, H. ET AL.: "Terpene isocyanides, isocyanates, and isothiocyanates from the Okinawan Marine Sponge Stylissa sp.", J. NAT. PROD., vol. 67, 2004, pages 833 - 837, XP002641585
CHEN, X. ET AL.: "Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis", JOURNAL OF NATURAL PRODUCTS, vol. 65, no. 7, 2002, pages 1016 - 1020, XP003014891, ISSN: 0163-3864, DOI: DOI:10.1021/NP010561J
CHANG, J. ET AL.: "Novel cytotoxic seco-abietane rearranged diterpenoids from Salvia prionitis", PLANTA MEDICA, vol. 71, no. 9, 2005, pages 861 - 866, XP002641586
MITOME, H. ET AL.: "Terpene isocyanides, isocyanates, and isothiocyanates from the Okinawan Marine Sponge Stylissa sp.", J. NAT. PROD., vol. 67, 2004, pages 833 - 837, XP002641585
CHEN, X. ET AL.: "Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis", JOURNAL OF NATURAL PRODUCTS, vol. 65, no. 7, 2002, pages 1016 - 1020, XP003014891, ISSN: 0163-3864, DOI: DOI:10.1021/NP010561J
CHANG, J. ET AL.: "Novel cytotoxic seco-abietane rearranged diterpenoids from Salvia prionitis", PLANTA MEDICA, vol. 71, no. 9, 2005, pages 861 - 866, XP002641586
Attorney, Agent or Firm:
BERNARDO NORIEGA, Francisco (S.L.Avenida de Burgos, 16, Edificio Euromor Madrid, ES)
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