Title:
PHENOXYACETIC ACID DERIVATIVE AND METHOD FOR PREPARING PENICILLIN V SALT BY USING ENZYMATIC METHOD OF PHENOXYACETIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/156176
Kind Code:
A1
Abstract:
The present application relates to the technical field of antibiotic medicine, and relates to a phenoxyacetic acid derivative and a method for preparing a penicillin V salt by using an enzymatic method of said phenoxyacetic acid derivative. The derivative is glyceryl phenoxyacetate. The method comprises the following steps: (1) in an aqueous solution, causing 6-APA and the derivative to react under the catalysis of penicillin acylase; (2) after reaction is complete, obtaining penicillin V by means of an acidification reaction, and obtaining a penicillin V salt after salinization and then isolation. By using the phenoxyacetic acid derivative and the method for preparing a penicillin V salt by using an enzymatic method of said phenoxyacetic acid derivative as described in the present application, a penicillin V salt may be better prepared by using an enzymatic method.
Inventors:
XU GANG (CN)
ZHANG JIAO (CN)
ZENG HONGYU (CN)
HUANG BIN (CN)
SONG ZIBO (CN)
ZHANG JIAO (CN)
ZENG HONGYU (CN)
HUANG BIN (CN)
SONG ZIBO (CN)
Application Number:
PCT/CN2020/072246
Publication Date:
August 06, 2020
Filing Date:
January 15, 2020
Export Citation:
Assignee:
HUNAN FLAG BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07C69/66; C12P37/04
Foreign References:
| CN109628541A | 2019-04-16 |
Other References:
MANOVICIU, IONEL ET AL.: "Esters of phenoxyacetic acids with trihydric and tetrahydric alcohols", MATERIALE PLASTICE, vol. 3, no. 31, 31 December 1994 (1994-12-31), Bucharest, pages 202 - 205
COURSE ON MEDICAL CHEMISTRY, VOCATIONAL SECONDARY SCHOOL, 31 January 2006 (2006-01-31), pages 237 - 239
COURSE ON MEDICAL CHEMISTRY, VOCATIONAL SECONDARY SCHOOL, 31 January 2006 (2006-01-31), pages 237 - 239
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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