PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES

FIELD OF THE INVENTION The present invention relates to a group of phenylthiazolylpiperazine derivatives, their use as a medicament, and more particularly their use for the manufacture of a medicament for treating certain neurological disorders characterised by cytotoxic α-synuclein amyloidogenesis. The invention further relates to pharmaceutical compositions comprising one or more compounds from said group of derivatives.

BACKGROUND OF THE INVENTION α-Synuclein is a neuronal protein, which originally has been associated with neuronal plasticity during Zebra finch song learning. Although its role at the molecular level is at present largely elusive it appears to have lipid bi-layer (or membrane) with binding properties important for preserving proper transport of neurotransmitter vesicles to the axonal ends of neurons presumably to ensure proper signalling at the synapse. Apart from its physiological role in brain cells, human α-synuclein also possesses pathological features that underlies a plethora of neurodegenerative diseases including Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. These neurological disorders are characterised by the presence of insoluble α-synuclein polymers or aggregates usually residing within neuronal cells, although in the case of Alzheimer's disease α-synuclein (or proteolytic fragments thereof) constitutes the non-amyloid component of extracellular " amyloid-β plaques ". It is widely believed that the amyloidogenic properties α-synuclein disrupt cellular integrity leading to dysfunctioning or death of affected neurons resulting in cognitive and/or motoric decline as it is found in patients suffering from such diseases. The aggregation of α-synuclein is at present very poorly defined, but constitutes most likely a multi-step process wherein self-polymerization of α-synuclein into insoluble aggregates is preceded by the formation of soluble protofibrils of α-synuclein monomers. Self-association may be triggered by the formation of alternative conformations of α-synuclein monomers with high propensity to polymerize. Several studies using neuronal cell lines or whole animals have shown that formation of

reactive oxygen species (hereinafter abbreviated as ROS) appear to stimulate noxious α-synuclein amyloidogenesis. For instance paraquat (an agent stimulating ROS formation within the cell) has been recognized as a stimulator of α-synuclein aggregation. Like in animals, exposure to paraquat is believed to induce the formation of synuclein inclusions, and consequently neurodegeneration, especially of dopaminergic neurons in humans. Dopaminergic neurons appear to be particularly sensitive because the concurrent dopamine metabolism may on the one hand contribute significantly to the oxidative stress load but may on the other hand result in kinetic stabilisation of highly toxic protofibrillar α-synuclein species by dopamine (or its metabolic derivatives). Parkinson's disease is characterised by a selective loss of dopaminergic substantia nigra cells and therefore treatment of animals (or neuronal cells) with paraquat is a common well-accepted experimental set-up for studying synucleopathies, in particular Parkinson's disease.

Apart from ROS, mutations in the coding region of the α-synuclein gene have also been identified as stimulators of self-polymerization resulting in early disease onset as it is observed in families afflicted by such mutations. Finally, increased expression of α-synuclein also promotes early disease onset as evidenced by a duplication or triplication of the α-synuclein gene in the genome of some individuals. The molecular mechanism by which α-synuclein self-association triggers cellular degeneration is at present largely unknown. Although it has been speculated that insoluble aggregates affect cellular integrity, it has recently been suggested that soluble protofibrillar intermediates of the aggregation process are particularly toxic for the cell as opposed to mature insoluble fibrils which may be inert end-products or may even serve as cytoprotective reservoirs of otherwise harmful soluble species. Therapeutic attempts to inhibit formation of insoluble aggregates may therefore be conceptually wrong, possibly even promoting disease progress.

While the identification of pathological α-synuclein mutations unequivocally revealed a causative factor of a plethora of neurodegenerative disorders, treatments ensuring suppression of toxic α-synuclein amyloidogenesis are presently not available. Only symptomatic treatments of Parkinson's disease exist, which aim e.g. at increasing dopamine levels in order to replenish its lowered level due to degeneration of dopaminergic neurons, for instance by administrating L-DOPA or inhibitors of dopamine breakdown. Although such treatments suppress disease symptoms to some extent, they are only temporarily effective and certainly do not slow down ongoing neuronal degeneration.

Thus there is a need in the art for designing new drugs for therapeutic treatments that target the underlying molecular mechanism of α-synuclein related pathologies in order to reduce neuronal cell death and/or degeneration.

SUMMARY OF THE INVENTION

According to a first aspect, the present invention relates a group of novel thiazolylpiperazine derivatives, in particular substituted 1-(4-phenyl-1 ,3-thiazol-2-yl)-4- sulfonylpiperazines, 1-(4-benzyl-1 ,3-thiazol-2-yl)-4-sulfonylpiperazines and N-sulfonyl heterocyclic derivatives (in particular substituted 1-(4-phenyl-1 ,3-thiazol-2-yl)-4- sulfonylpiperidines and 1-(4-benzyl-1 ,3-thiazol-2-yl)-4-sulfonylpiperidines) such as defined in the detailed description of the invention.

According to another aspect the present invention relates to a group of thiazolylpiperazine derivatives for use in the manufacture of a medicament.

According to another aspect, the present invention relates to pharmaceutical compositions comprising such compounds as active ingredients that effectively counteract or inhibit the toxic properties of α-synuclein, said compositions being useful for the prevention and/or treatment of an α-synucleopathy such as, but not limited to, Parkinson's disease, diffuse Lewy body disease, multiple system atrophy and Alzheimer's disease. According to another aspect, the present invention relates to the use of such thiazolylpiperazine derivatives in the treatment and/or prevention of α-synucleopathies, such as, but not limited to Parkinson's disease, diffuse Lewy body disease, multiple system atrophy and Alzheimer's disease. According to another aspect, the present invention also relates to methods of treatment of α-synucleopathies, such as, but not limited to Parkinson's disease, diffuse Lewy body disease, multiple system atrophy and Alzheimer's disease, including the administration of a therapeutically effective amount of such a thiazolylpiperazine derivative to a patient in need thereof.

BRIEF DESCRIPTION OF THE DRAWING Figure 1 shows the sensitivity of an α-synuclein expressing neuroblastoma cell line to paraquat.

Figure 2 shows synthetic schemes for the preparation of phenylthiazolyl- piperazine derivatives according to this invention.

DEFINITIONS

As used herein with respect to a substituting group, and unless otherwise stated, the term " Ci _-4 alkyl " means straight and branched chain saturated acyclic hydrocarbon monovalent groups having from 1 to 4 carbon atoms such as, for example, methyl, ethyl, propyl, n-butyl, 1-methylethyl (isopropyl), 2-methylpropyl (isobutyl) and 1 , 1 -dimethylethyl (ter-butyl). By analogy, the term " d- ₆ alkyl " refers to such radicals having from 1 to 6 carbon atoms, including 2-methylbutyl, n-pentyl, dimethylpropyl, n-hexyl, 2-methylpentyl, 3-methylpentyl, and the like.

As used herein with respect to a substituting group, and unless otherwise stated, the term " aryl " designate any mono- or polycyclic aromatic monovalent hydrocarbon group having from 6 up to 30 carbon atoms such as but not limited to phenyl, naphthyl, anthracenyl, phenantracyl, fluoranthenyl, chrysenyl, pyrenyl, biphenylyl, terphenyl, picenyl, indenyl, biphenyl, indacenyl, benzocyclobutenyl, benzocyclooctenyl and the like, including fused benzo-C _4-8 cycloalkyl groups such as, for instance, indanyl, tetrahydronaphtyl, fluorenyl and the like, all of the said radicals being optionally substituted with one or more substituents independently selected from the group consisting of halogen, amino, trifluoromethyl, hydroxyl, sulfhydryl and nitro, such as for instance 4-fluorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 4- cyanophenyl, 2,6-dichlorophenyl, 2-fluorophenyl, 3-chlorophenyl, 3,5-dichlorophenyl and the like.

As used herein with respect to a substituting group , and unless otherwise stated, the terms " Ci _-6 alkoxy " and " aryloxy ", refer to substituents wherein a carbon atom of a Ci _-6 alkyl, respectively or an aryl group (each of them such as defined herein), is attached to an oxygen atom through a single bond such as, but not limited to, methoxy, ethoxy, propoxy, butoxy, pentoxy, isopropoxy, sec-butoxy, tert-butoxy, isopentoxy, phenyloxy, and the like.

As used herein and unless otherwise stated, the term " stereoisomer " refers to all possible different isomeric as well as conformational forms which the compounds of structural formula may possess, in particular all possible stereochemical^ and conformational^ isomeric forms, all diastereomers, enantiomers and/or conformers of the basic molecular structure. Some compounds of the present invention may exist in different tautomeric forms, all of the latter being included within the scope of the present invention.

As used herein and unless otherwise stated, the term " enantiomer " means each individual optically active form of a compound of the invention, having an optical purity

or enantiomeric excess (as determined by methods standard in the art) of at least 80% (i.e. at least 90% of one enantiomer and at most 10% of the other enantiomer), preferably at least 90% and more preferably at least 98%.

As used herein and unless otherwise stated, the term " solvate " includes any combination which may be formed by a derivative of this invention with a suitable inorganic solvent (e.g. hydrates) or organic solvent, such as but not limited to alcohols, ketones, esters, ethers, nitriles and the like.

The term " α-synucleopathy " as used herein, unless otherwise stated, refers to a disease characterised by the presence of pathological deposition of insoluble α- synuclein polymers or aggregates intracellular^ and/or extracellularly. Such diseases include, but are not limited to, Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, and multiple system atrophy. As used herein, the term " Parkinson's disease " refers to a chronic progressive nervous disease characterised by neurodegeneration, especially degeneration of dopaminergic neurons. Symptoms include stooped posture, resting tremor, weakness of resting muscles, a shuffling gait, speech impediments, movement difficulties and an eventual slowing of mental processes and dementia. The term " neuroprotective " agent, as used herein, refers to drugs or chemical agents intended to prevent neurodegeneration, including drugs that slow down or stop the progression of neuronal degeneration.

As used herein with respect to a substituting group, and unless otherwise stated, the terms " heterocyclic " and " heterocyclyl " mean a mono- or polycyclic, saturated or mono-unsaturated or polyunsaturated monovalent hydrocarbon radical having from 2 up to 15 carbon atoms and including one or more heteroatoms in one or more heterocyclic rings, each of said rings having from 3 to 10 atoms (and optionally further including one or more heteroatoms attached to one or more carbon atoms of said ring, for instance in the form of a carbonyl or thiocarbonyl or selenocarbonyl group, and/or to one or more heteroatoms of said ring, for instance in the form of a sulfone, sulfoxide, N-oxide, phosphate, phosphonate or selenium oxide group), each of said heteroatoms being independently selected from the group consisting of nitrogen, oxygen, sulfur, selenium and phosphorus, also including radicals wherein a heterocyclic ring is fused to one or more aromatic hydrocarbon rings for instance in the form of benzo-fused, dibenzo-fused and naphtho-fused heterocyclic radicals; within this

definition are included heterocyclic radicals such as, but not limited to, diazepinyl, oxadiazinyl, thiadiazinyl, dithiazinyl, triazolonyl, diazepinonyl, triazepinyl, triazepinonyl, tetrazepinonyl, benzoquinolinyl, benzothiazinyl, benzothiazinonyl, benzoxa-thiinyl, benzodioxinyl, benzodithiinyl, benzoxazepinyl, benzothiazepinyl, benzodiazepinyl, benzodioxepinyl, benzodithiepinyl, benzoxazocinyl, benzothiazocinyl, benzodiazocinyl, benzoxathiocinyl, benzodioxocinyl, benzotrioxepinyl, benzoxathiazepinyl, benzoxa- diazepinyl, benzothiadiazepinyl, benzotriazepinyl, benzoxathiepinyl, benzotriazinonyl, benzoxazolinonyl, azetidinonyl, azaspiroundecyl, dithiaspirodecyl, selenazinyl, selen- azolyl, selenophenyl, hypoxanthinyl, azahypo-xanthinyl, bipyrazinyl, bipyridinyl, oxazolidinyl, diselenopyrimidinyl, benzodioxocinyl, benzopyrenyl, benzopyranonyl, benzophenazinyl, benzoquinolizinyl, dibenzocarbazolyl, dibenzoacridinyl, dibenzo- phenazinyl, dibenzothiepinyl, dibenzoxepinyl, dibenzopyranonyl, dibenzoquinoxalinyl, dibenzothiazepinyl, dibenzisoquinolinyl, tetraazaadamantyl, thiatetraazaadamantyl, oxauracil, oxazinyl, dibenzothiophenyl, dibenzofuranyl, oxazolinyl, oxazolonyl, azaindolyl, azolonyl, thiazolinyl, thiazolonyl, thiazolidinyl, thiazanyl, pyrimidonyl, thiopyrimidonyl, thiamorpholinyl, azlactonyl, naphthindazolyl, naphthindolyl, naphthothiazolyl, naphthothioxolyl, naphthoxindolyl, naphthotriazolyl, naphthopyranyl, oxabicycloheptyl, azabenzimidazolyl, azacycloheptyl, azacyclooctyl, azacyclononyl, azabicyclononyl, tetrahydrofuryl, tetrahydropyranyl, tetrahydropyronyl, tetrahydroquinoleinyl, tetrahydro-thienyl and dioxide thereof, dihydrothienyl dioxide, dioxindolyl, dioxinyl, dioxenyl, dioxazinyl, thioxanyl, thioxolyl, thiourazolyl, thiotriazolyl, thiopyranyl, thiopyronyl, coumarinyl, quinoleinyl, oxyquinoleinyl, quinuclidinyl, xanthinyl, dihydropyranyl, benzodihydrofuryl, benzothiopyronyl, benzothiopyranyl, benzoxazinyl, benzoxazolyl, benzodioxolyl, benzodioxanyl, benzothiadiazolyl, benzotriazinyl, benzothiazolyl, benzoxazolyl, phenothioxinyl, phenothiazolyl, phenothienyl (benzothiofuranyl), phenopyronyl, phenoxazolyl, pyridinyl, dihydropyridinyl, tetrahydropyridinyl, piperidinyl, morpholinyl, thiomorpholinyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, tetrazinyl, triazolyl, benzotriazolyl, tetrazolyl, imidazolyl, pyrazolyl, thiazolyl, thiadiazolyl, isothiazolyl, oxazolyl, oxadiazolyl, pyrrolyl, furyl, dihydrofuryl, furoyl, hydantoinyl, dioxolanyl, dioxolyl, dithianyl, dithienyl, dithiinyl, thienyl, indolyl, indazolyl, benzofuryl, quinolyl, quinazolinyl, quinoxalinyl, carbazolyl, phenoxazinyl, phenothiazinyl, xanthenyl, purinyl, benzothienyl, naphthothienyl, thianthrenyl, pyranyl, pyronyl, benzopyronyl, isobenzofuranyl, chromenyl, phenoxathiinyl, indolizinyl, quinolizinyl, isoquinolyl, phthalazinyl, naphthiridinyl, cinnolinyl, pteridinyl, carbolinyl, acridinyl, perimidinyl, phenanthrolinyl, phenazinyl, phenothiazinyl, imidazolinyl,

imidazolidinyl, benzimidazolyl, pyrazolinyl, pyrazolidinyl, pyrrolinyl, pyrroli-dinyl, piperazinyl, uridinyl, thymidinyl, cytidinyl, azirinyl, aziridinyl, diazirinyl, diaziridinyl, oxiranyl, oxaziridinyl, dioxiranyl, thiiranyl, azetyl, dihydroazetyl, azetidinyl, oxetyl, oxetanyl, oxetanonyl, homopiperazinyl, homopiperidinyl, thietyl, thietanyl, diazabicyclooctyl, diazetyl, diaziridinonyl, diaziridinethionyl, chromanyl, chromanonyl, thiochromanyl, thiochromanonyl, thiochromenyl, benzofuranyl, benzisothiazolyl, benzocarbazolyl, benzochromonyl, benzisoalloxazinyl, benzocoumarinyl, thiocoumarinyl, phenometoxazinyl, phenoparoxazinyl, phentriazinyl, thiodiazinyl, thiodiazolyl, indoxyl, thioindoxyl, benzodiazinyl (e.g. phthalazinyl), phthalidyl, phthalimidinyl, phthalazonyl, alloxazinyl, dibenzopyronyl (i.e. xanthonyl), xanthionyl, isatyl, isopyrazolyl, isopyrazolonyl, urazolyl, urazinyl, uretinyl, uretidinyl, succinyl, succinimido, benzylsultimyl, benzylsultamyl and the like, including all possible isomeric forms thereof, wherein each carbon atom of said heterocyclic ring may furthermore be independently substituted with a substituent selected from the group consisting of halogen, nitro, C _1-7 alkyl (optionally containing one or more functions or radicals selected from the group consisting of carbonyl (oxo), alcohol (hydroxyl), ether (alkoxy), acetal, amino, imino, oximino, alkyloximino, amino-acid, cyano, carboxylic acid ester or amide, nitro, thio C _1-7 alkyl, thio C _3-10 cycloalkyl, C _1-7 alkylamino, cycloalkylamino, alkenylamino, cycloalkenylamino, alkynylamino, arylamino, arylalkyl-amino, hydroxylalkylamino, mercaptoalkylamino, heterocyclic-substituted alkylamino, heterocyclic amino, heterocyclic-substituted arylamino, hydrazine alkylhydrazino, phenylhydrazino, sulfonyl, sulfonamido and halogen), C _3-7 alkenyl, C _2-7 alkynyl, halo C _1- 7 alkyl, C _3-10 cycloalkyl, aryl, arylalkyl, alkylaryl, alkylacyl, arylacyl, hydroxyl, amino, C _1-7 alkylamino, cycloalkylamino, alkenylamino, cycloalkenylamino, alkynylamino, arylamino, arylalkylamino, hydroxyalkylamino, mercaptoalkylamino, heterocyclic- substituted alkyl-amino, heterocyclic amino, heterocyclic-substituted arylamino, hydrazine alkylhydrazino, phenylhydrazino, sulfhydryl, C _1-7 alkoxy, C _3-10 cycloalkoxy, aryloxy, arylalkyloxy, oxyheterocyclic, heterocyclic-substituted alkyloxy, thio C _1-7 alkyl, thio C _3-10 cycloalkyl, thioaryl, thioheterocyclic, arylalkylthio, heterocyclic-substituted alkylthio, formyl, hydroxylamino, cyano, carboxylic acid or esters or thioesters or amides thereof, thiocarboxylic acid or esters or thioesters or amides thereof; depending upon the number of unsaturations in the 3 to 10 atoms ring, heterocyclic radicals may be sub-divided into heteroaromatic (or " heteroaryl ") radicals and non-aromatic heterocyclic radicals; when a heteroatom of said non-aromatic heterocyclic radical is

nitrogen, the latter may be substituted with a substituent selected from the group consisting of Ci _-7 alkyl, C3- ₁ 0 cycloalkyl, aryl, arylalkyl and alkylaryl.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates, to a group of 1-thiazolyl-4-sulfonylpiperazine derivatives, which have desirable biological properties such as an inhibitory effect on α- synuclein mediated toxicity. Based on this inhibitory activity, and the fact that these compounds are not toxic to neural cells, these compounds are useful for the manufacture of medicament for the prevention and/or treatment of α-synucleopathies.

The ability of the compounds of the invention to inhibit α-synuclein mediated toxicity is based on their activity in the α-synuclein cytotoxicity test described in the examples herein after. Treatment of mice with mitochondrial complex I inhibitors such as paraquat or MPTP (1-methyl-4-phenyl-1 ,2,3,6-tetrahydropyridine) is a well-accepted and commonly used experimental set-up to study neuronal degeneration. Paraquat triggers synuclein-aggregation, which allegedly triggers a specific loss of dopaminergic neurons and ultimately a decline in the locomotion function. Briefly, one or more compounds are administered to paraquat-receiving mice and the onset of motoric dysfunction is assessed using a rotary rod device. A delay or absence in the occurrence of motoric problems in compound treated mice (compared to control mice treated with only vehicle) indicates that the compound(s) inhibit(s) synuclein-dependent degeneration of dopaminergic cells.

According to a first aspect, the present invention provides a group of phenylthiazolylpiperazine derivatives that can be used in the treatment of an α- synucleopathy. The novel compounds according to this aspect of the present invention are represented by the structural formula (I)

(I) wherein: - W is selected from the group consisting of a single bond, methylene (CH ₂ ), bis- methylene (CH ₂ -CH ₂ ) and methylidene (vinylene) (CH=CH);

Ri is selected from the group consisting of Ci _-2 o alkyl, C _3-I0 cycloalkyl, arylCi _-4 alkyl, aryl-C ₂ -4 alkenyl, and C3-10 cycloalkyl-Ci _-6 alkyl, wherein said Ci _-2 o alkyl, C3-10 cycloalkyl or aryl-Ci _-4 alkyl is optionally substituted by one or more substituents independently selected from the group consisting of halogen, cyano, nitro, aryloxy, carboxylic acid (CO ₂ H) and Ci _-4 alkyl esters thereof; or R ₁ is a phenyl ring optionally substituted with one or more substituents independently selected from the group consisting of Ci _-6 alkyl, Ci _-6 alkoxy, aryl, aryloxy, hydroxy, acetyl, nitro, trifluoromethyl and halogen; or any two adjacent substituents of said phenyl ring form, together with the phenyl ring carbon atoms to which they are attached, a saturated or unsaturated ring fused to said phenyl ring and having from 5 to 7 ring members, said saturated or unsaturated ring optionally comprising one or two heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen; and each of said Ci _-6 alkyl, Ci _-6 alkoxy, aryl or fused ring is optionally substituted with one or more halogen atoms; or Ri is a heterocyclyl optionally substituted with one or more substituents independently selected from R ₈ and R ₉ ;

R ₂ is a phenyl ring optionally substituted with one or more substituents independently selected from the group consisting of Ci _-6 alkyl, Ci _-6 alkoxy, aryl, aryloxy, hydroxy, acetyl, nitro, trifluoromethyl and halogen; or any two adjacent substituents of said phenyl ring form, together with the phenyl ring carbon atoms to which they are attached, a saturated or unsaturated ring fused to said phenyl ring and having from 5 to 7 ring members, said saturated or unsaturated ring optionally comprising one or two heteroatoms independently selected from the group consisting of oxygen, sulfur and nitrogen; and each of said Ci _-6 alkyl, Ci _-6 alkoxy, aryl or fused ring is optionally substituted with one or more halogen atoms, or R ₂ is a heterocyclyl optionally substituted with one or more substituents independently selected from R ₈ and R ₉ ;

R ₃ is selected form the group consisting of a hydrogen atom and Ci _-6 alkyl; each R ₈ is independently selected from the group consisting of Ci_io alkyl, Ci _-6 alkenyl, Ci _-6 alkynyl, Ci _-6 alkoxy, aryl, aryloxy, aryl-Ci _-6 alkyl, heterocyclyl, heterocyclyl-d-ealkyl, heterocyclyl oxy, Ci _-6 alkanoyl wherein each of said R ₈ is optionally substituted with one or more substituents independently selected from the group consisting of halogen, oxo, thioxo, C _1-6 alkyl, Ci _-6 alkoxy, amino, C _1-6 alkyl- amino, di-Ci _-6 alkyl-amino, C _1-6 alkylthio, -CN, -NO, -C(O)-NRi ₄ Ri ₅ , -C(O)-Ri ₅ , -NH- C(O)-Ri ₄ , -0-C(O)-Ri ₄ , -C(O)-O-Ri ₄ , -S(O)-Ri ₄ , -S(O) ₂ -Ri ₄ , -S(O) ₂ -NRi ₄ Ri ₅ ; and

each R ₉ is independently selected from the group consisting of OH, NO ₂ , halogen, NH ₂ , Ci _-6 alkyl-amino, di-Ci _-6 alkyl-amino, -CN, -NO, -C(O)-NR ₁₄ Ri ₅ , -C(O)-Ri ₅ , -NH- C(O)-Ri ₄ , -O-C(O)-Ri4, -C(O)-O-Ri ₄ , -S(O)-Ri ₄ , -S(O) ₂ -Ri ₄ , -S(O) ₂ -NRi ₄ Ri ₅ , and Ci- ₆ alkylthio; - each R _M is independently selected from the group consisting of hydrogen, Ci _-6 alkyl, Ci _-6 alkenyl, Ci _-6 alkynyl, aryl, aryl Ci _-6 alkyl, C _3- io cycloalkyl and heterocyclyl; each Ri ₅ is independently selected from the group consisting of hydrogen and Ci _-6 alkyl; or a stereoisomer thereof, or an enantiomer thereof, or a N-oxide thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, provided that said derivative is not:

1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine; 1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine; 1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine; 1-(4-phenyl-3-propyl-1 ,3-thiazol-2-yl)-4-[(4-methylphenyl)sulfonyl]-piperazine;

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine; 1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine; 1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine; 1 -[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine; or 1 -[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine.

According to another aspect, the present invention provides a group of N- sulfonyl heterocyclic derivatives that can be used in the treatment of an α- synucleopathy. The novel compounds according to this aspect of the present invention are represented by the structural formula (IV)

wherein:

A is CH or N and the divalent group schematically represented by the structural formula (G)

includes an optionally mono-substituted or poly-substituted, saturated heterocyclic ring with one or two nitrogen atoms in the said heterocyclic ring and with a total of 5 to 7 atoms in the said heterocyclic ring, - each R ₁ is independently selected from the group consisting of C _1-4 alkyl,

C _1-4 alkenyl or C _1-4 alkynyl;

- n is 0, 1 , 2 or 3;

R ₂ is hydrogen or C _1-6 alkyl;

Ak ₁ and Ak ₂ are linking moieties independently selected from the group consisting of a single bond; divalent saturated, ethylenically unsaturated and acetylenically unsaturated non-cyclic hydrocarbon groups comprising from 1 to 3 atoms in the main chain;

Cy ₁ and Cy ₂ are independently selected from the group consisting of C _3-1 O cycloaklyl, aryl-C _1-4 alkyl, aryl-C _2-4 alkenyl and C _3-1 ocycloalkyl-C _1-6 alkyl; wherein said C _3-1 O cycloaklyl or aryl-C _1-4 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of hydroxyl, acetyl, nitro, cyano, acetamido, trifluoromethyl, NH ₂ , SO ₂ and halogen; or Cy ₁ and Cy ₂ are independently a phenyl ring optionally substituted with one or more substituents independently selected from the group consisting of C _1-6 alkyl, C _1-6 alkoxy, aryl, aryloxy, hydroxyl, acetyl, nitro, cyano, acetamido, trifluoromethyl, NH ₂ , SO ₂ , OCH ₂ COOCH ₃ , heterocyclyl and halogen; and said heteocyclyl ring is optionally substituted with one or more R ₃ ; or any two adjacent substituents of said phenyl ring form, together with the phenyl ring carbon atoms to which they are attached, a saturated or unsaturated ring fused to said phenyl ring and having from 5 to 7 ring members, said saturated or unsaturated ring optionally comprising one or two heteroatoms independently selected from

the group consisting of O, S and N; and each of said Ci _-6 alkyl, Ci _-6 alkoxy, aryl or fused ring is optionally substituted with one or more substituents selected from the group consisting of Ci _-6 alkyl, oxo and halogen; or Cyi and Cy ₂ are independently a heterocyclyl optionally substituted with one or more R ₃ ; and each R ₃ is independently selected from the group consisting of Ci _-6 alkyl, Ci _-6 alkoxy, aryl, aryloxy, hydroxyl, acetyl, nitro, cyano, acetamido, trifluoromethyl, NH ₂ , SO ₂ , oxo and halogen; or a stereoisomer thereof, or an enantiomer thereof, or a N-oxide thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof.

These derivatives - being represented by the structural formula (I) or the structural formula (IV) - may also be in the form of a pharmaceutically acceptable salt. The latter include any therapeutically active non-toxic addition salt, which these compounds are able to form with a salt-forming agent. Such addition salts may conveniently be obtained by treating the derivatives of the invention with an appropriate salt-forming acid. For instance, derivatives may be converted into the corresponding therapeutically active, non-toxic acid addition salt form by treating the free base form with a suitable amount of an appropiate acid following conventional procedures. Examples of such appropriate salt-forming acids include, for instance, inorganic acids resulting in forming salts such as but not limited to hydrohalides (e.g. hydrochloride and hydrobromide), sulfate, nitrate, phosphate, diphosphate, carbonate, bicarbonate, and the like; and organic monocarboxylic or dicarboxylic acids resulting in forming salts such as, for example, acetate, propanoate, hydroxyacetate, 2-hydroxypropanoate, 2- oxopropanoate, lactate, pyruvate, oxalate, malonate, succinate, maleate, fumarate, malate, tartrate, citrate, methanesulfonate, ethanesulfonate, benzoate, 2- hydroxybenzoate, 4-amino-2-hydroxybenzoate, benzene-sulfonate, p-toluenesulfonate, salicylate, p-aminosalicylate, pamoate, bitartrate, camphorsulfonate, edetate, 1 ,2- ethanedisulfonate, fumarate, glucoheptonate, gluconate, glutamate, hexylresorcinate, hydroxynaphtoate, hydroxyethanesulfonate, mandelate, methylsulfate, pantothenate, stearate, as well as salts derived from ethanedioic, propanedioic, butanedioic, (Z)-2- butenedioic, (E)2-butenedioic, 2-hydroxybutanedioic, 2,3-dihydroxybutane-dioic, 2- hydroxy-1 ,2,3-propanetricarboxylic and cyclohexanesulfamic acids and the like.

Reaction conditions for treating the derivatives with an appropriate salt-forming acid are similar to standard conditions involving the same acid or base but different

organic compounds with basic or acidic properties, respectively. Preferably, in view of its use in a pharmaceutical composition or in the manufacture of a medicament for treating specific diseases, the pharmaceutically acceptable salt will be designed, i.e. the salt-forming acid or base will be selected, so as to impart greater water-solubility, lower toxicity, greater stability and/or slower dissolution rate to the derivative of this invention.

The derivatives according to this first aspect of the invention, including all 9 above excluded (commercially available) compounds, are particularly suitable for the manufacture of a medicament for treating an α-synucleopathy, e.g. Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy or Alzheimer's disease.

According to a second aspect, the present invention provides pharmaceutical compositions containing at least one of the above-defined derivatives, including all 9 above excluded (commercially available) compounds, together with one or more pharmaceutically acceptable carriers or excipients.

The term " pharmaceutically acceptable carrier or excipient " as used herein in relation to pharmaceutical compositions and combined preparations means any material or substance with which the active principle may be formulated in order to facilitate its application or dissemination to the locus to be treated, for instance by dissolving, dispersing or diffusing the said composition, and/or to facilitate its storage, transport or handling without impairing its effectiveness. The pharmaceutically acceptable carrier may be a solid or a liquid or a gas which has been compressed to form a liquid, i.e. the compositions of this invention can suitably be used as concentrates, emulsions, solutions, granulates, dusts, sprays, aerosols, pellets or powders.

Suitable pharmaceutical carriers for use in the said pharmaceutical compositions and their formulation are well known to those skilled in the art. There is no particular restriction to their selection within the present invention although, due to the usually low or very low water-solubility of the derivatives of this invention, special attention will be paid to the selection of suitable carrier combinations that can assist in properly formulating them in view of the expected time release profile. Suitable pharmaceutical carriers include additives such as wetting agents, dispersing agents, stickers, adhesives, emulsifying or surface-active agents, thickening agents, complexing agents, gelling agents, solvents, coatings, antibacterial and antifungal

agents (for example phenol, sorbic acid, chlorobutanol), isotonic agents (such as sugars or sodium chloride) and the like, provided the same are consistent with pharmaceutical practice, i.e. carriers and additives which do not create permanent damage to mammals. The pharmaceutical compositions of the present invention may be prepared in any known manner, for instance by homogeneously mixing, dissolving, spray-drying, coating and/or grinding the active ingredients, in a one-step or a multi-steps procedure, with the selected carrier material and, where appropriate, the other additives such as surface-active agents, may also be prepared by micronisation, for instance in view to obtain them in the form of microspheres usually having a diameter of about 1 to 10 μm, namely for the manufacture of microcapsules for controlled or sustained release of the biologically active ingredient(s).

The various thiazolylpiperazine derivatives of the present invention can be synthesised according to the general schemes 1 , 2 and 3 represented in Figure 2, and described hereafter. The last step, represented in scheme 1 of Figure 2, consists in the reaction between a compound represented by the structural formula (II) and a compound represented by the structural formula (III) under reaction conditions known in the art for the formation of thiazole derivatives (i.e. Hantzch synthesis of thiazoles).

Suitable compounds represented by the structural formula (II) wherein W is a single bond include, but are not limited to, commercially available products such as bromo-acetophenone, 2,3'-dibromoacetophenone, 2-bromo-4'-chloroacetophenone, 2- bromo-4'-methoxyacetophenone, 2-bromo-3'-methoxyacetophenone, 2-bromo-2'- methoxyacetophenone, 2-bromo-4'-methylacetophenone, 2-bromo-3'-methyl- acetophenone, 2-bromo-2'-methylacetophenone, 2-bromo-4'-ethylacetophenone, 2- bromo-4'-propylacetophenone, 2-bromo-4'-isopropylacetophenone, 2, 2', 4'- trichloroacetophenone; 2-chloroacetophenone, 2-bromopropiophenone; 2,4'- Dibromopropiophenone and 2-bromo-4'-n-butylacetophenone. Other compounds represented by the structural formula (II) can be obtained for example, as represented in scheme 2 of Figure 2, by halogenation of the corresponding ketone. Conditions for halogenation of arylalkylketone derivatives are known in the art, preferably acidic conditions are used in order to limit to monohalogenation. Arylalkylketones that may be used for halogenation are, but not limited to, commercially available products such as 3'-methoxyacetophenone; 3'-chloro-acetophenone; 2'-nitroacetophenone; 3'- nitroacetophenone; 4'-nitroacetophenone; 3'-ethylacetophenone; 4'-tert- butylacetophenone; 4'-n-propylacetophenone; 4'-iso-propylacetophenone; 4'-

isobutoxyacetophenone; 4'-propoxyacetophenone; 2'-methoxyacetophenone; 2'- fluoroacetophenone; 4'-fluoroacetophenone; 2',5'-dimethoxyacetophenone; 2,2- dichloroacetophenone; 3'-fluoroacetophenone; 2,4'-dibromoacetophenone; 4'- chloroacetophenone; 4'-bromoacetophenone; 3'-bromoacetophenone; acetophenone; 2',4'-difluoropropiophenone; 3'-bromo-4'-fluoropropiophenone; 3'-chloropropiophenone; 4'-methylpropiophenone; 3'-bromo-propiophenone; 4'-fluoropropiophenone; propiophenone; 4'-methoxypropiophenone; 4'-chloropropiophenone; 3'- nitropropiophenone; 4'-bromopropiophenone; 4'-chloropropiophenone; 1-(2,4- dichlorophenyl)-1-propanone; 1-(3,4-dichlorophenyl)-1-propanone; 4'- chlorobutyrophenone; 4'-methoxybutyrophenone; n-butyrophenone; 1-(2,4- dichlorophenyl)-1-propanone; and 1-phenyl-1-pentanone (valerophenone).

Alternatively, suitable compounds represented by the structural formula (II) wherein W is a single bond can also be obtained by reaction of a corresponding phenylhalogenomagnesium or heterocyclylhalogenomagnesium with an adequate 2- chloroacetate derivative. Suitable phenylhalogenomagnesium and heterocyclyl- halogenomagneisum compounds include, but are not limited to, commercially available products such as phenylmagnesium bromide, 4-methoxyphenylmagnesium bromide, 4- chlorophenyl-magnesium bromide, 4-fluorophenylmagnesium bromide, 1- naphthylmagnesium bromide, phenylmagnesium chloride, o-tolylmagnesium bromide, m-tolylmagnesium bromide, p-tolylmagnesium bromide, o-tolylmagnesium chloride, m- tolylmagnesium chloride, 3,4-dichlorophenylmagnesium bromide, 3,5- dichlorophenylmagnesium bromide, 3,4-difluorophenylmagnesium bromide, 3,5- difluorophenylmagnesium bromide, 3-chloro-4-fluorophenylmagnesium bromide, 3- chloro-5-fluorophenylmagnesium bromide, 4-chloro-3-fluorophenylmagnesium bromide, 3,5-dimethylphenylmagnesium bromide, 3,4-dimethylphenylmagnesium bromide, 2,3- dimethylphenylmagnesium bromide, 2,4-dimethylphenylmagnesium bromide, 2,5- dimethylphenylmagnesium bromide, 2,6-dimethylphenylmagnesium bromide, 2,4- dimethoxyphenylmagnesium bromide, 2,5-dimethoxyphenylmagnesium bromide, 3,4- dimethoxyphenylmagnesium bromide, 3,5-dimethoxyphenylmagnesium bromide, 3,4,5- trimethoxyphenylmagnesium bromide, 2,4,5-trimethylphenyl-magnesium bromide, 4- ethylphenylmagnesium bromide, 4-ethoxyphenylmagnesium bromide, 2,4,6- trimethylphenylmagnesium bromide, 2-pyridylmagnesium bromide, 3- thienylmagnesium iodide.

Compounds of formula (II) wherein W is methylene, bismethylene or methylidene (vinylene) can be obtained for example, as represented in scheme 2 of

Figure 2, by reaction of an arylalkylhalogenomagnesium or arylalkenyl- halogenomagnesium compound with an adequate 2-chloroacetate derivative.

Arylalkylhalogenomagnesium compounds that are suitable for the synthesis of this invention include, but are not limited to, commercially available products such as benzylmagnesium chloride, 4-methylbenzylmagnesium chloride, 3-methyl- benzylmagnesium chloride, 2-methylbenzylmagnesium chloride, 4-methoxybenzyl- magnesium chloride, 3-methoxybenzylmagnesium chloride, 2-methoxybenzyl- magnesium chloride, 4-chlorobenzylmagnesium chloride, 3-chlorobenzylmagnesium chloride, 2-chlorobenzylmagnesium chloride, 4-fluorobenzylmagnesium chloride, 3- fluorobenzylmagnesium chloride, 2-fluorobenzylmagnesium chloride, 4- bromobenzylmagnesium bromide, 3-bromobenzylmagnesium bromide, and 2- bromobenzylmagnesium bromide.

Any commercially available arylalkyl halide or arylalkenyl halide can also be transformed in a desired Grignard reagent (arylalkylhalogenomagnesium or arylalkenylhalogenomagnesium compound) according to standard methods known in the art. For instance an arylalkyl bromide or arylalkyl chloride can be first transformed into the corresponding iodide in order to increase reactivity. Arylalkyl halides that may be used include, but are not limited to, commercially available compounds such as, benzyl iodide; 3-chlorobenzyl chloride; 3-methoxybenzyl bromide; 4-methoxybenzyl bromide; 4-ethoxybenzyl chloride; 4-isopropoxybenzyl chloride; 4-methoxybenzyl chloride; 2-iodobenzyl chloride; 2-bromobenzyl chloride; 3-bromobenzyl chloride; 4- bromobenzyl chloride; 2-chlorobenzyl chloride; 4-chlorobenzyl chloride; 2-fluoro-3- methylbenzyl bromide; 3,5-dimethylbenzyl bromide; 2,3,5,6-tetrafluorobenzyl bromide; 2,3,4,5-tetrafluorobenzyl bromide; 3,5-bis(trifluoromethyl)benzyl bromide; 4- (trifluoromethoxy)benzyl bromide; 3-nitrobenzyl bromide; 4-fluorobenzyl bromide; 2- fluorobenzyl bromide; 2-nitrobenzyl bromide; 4-nitrobenzyl bromide; 3-fluorobenzyl bromide; benzyl bromide; 2,4-dimethylbenzyl bromide, 3-phenoxybenzyl chloride; 2,6- difluorobenzyl chloride; 3-methoxybenzyl chloride; 2-methyl-3-nitrobenzyl chloride; 4- methyl-3-nitrobenzyl chloride; 5-methyl-2-nitrobenzyl chloride; 3-nitrobenzyl chloride; 3,4-dibenzyloxybenzyl chloride; benzyl chloride; 4-nitrobenzyl chloride; 2,5- dimethylbenzyl chloride; 2-nitrobenzyl chloride; 4-fluorobenzyl chloride; 3-fluorobenzyl chloride; 2-fluorobenzyl chloride; pentamethylbenzyl chloride; 2,4-dimethylbenzyl chloride; 3,4-difluorobenzyl chloride; 2-methoxybenzyl chloride; 2,5-difluorobenzyl chloride; (2-chloroethyl)benzene; 1-(2-chloroethyl)-4-methoxybenzene; (2-

bromoethyl)benzene; 4-Nitrophenethyl bromide; (2-iodoethyl)benzene and beta- bromostyrene.

Compounds represented by the structural formula (III), i.e. 1-[4- thiocarboxamido-1 ,3-thiazol-2-yl]-4-[(R ₁ -substituted)sulfonyl]piperazines, in particular 1-[4-thiocarboxamido-1 ,3-thiazol-2-yl]-4-arylsulfonylpiperazines and 1-[4-thio- carboxamido-1 ,3-thiazol-2-yl]-4-heterocyclylsulfonylpiperazines, can be obtained for example, as shown in scheme 3 of figure 2, starting with a mono-protected piperazine (e.g. a Boc mono-protected piperazine), by introducing a thioamide group using ethyl chloroformate and potassium thiocyanate under conditions known in the art, followed by deprotection (e.g. acidic deprotection of the Boc protecting group), and followed by reaction with a suitable corresponding arylsulfonyl chloride or heterocyclylsulfonyl chloride; or simply by using ethyl chloroformate and potassium thiocyanate directly onto a suitable arylsulfonylpiperazine or heterocyclylsulfonyl derivative (e.g. obtained by reaction of piperazine and a suitable sulfonyl chloride). Arylsulfonyl chlorides that may be used as precursors in scheme 3 of figure 2 include, but are not limited to, commercially available products such as 4- fluorobenzenesulfonyl chloride, 2-mesitylenesulfonyl chloride, 4-methoxybenzene- sulfonyl chloride, p-toluenesulfonyl chloride, pentafluorobenzenesulfonyl chloride, benzenesulfonyl chloride, 4-bromobenzenesulfonyl chloride, λ/-acetylsulfanilyl chloride, 2,4,6-triisopropyl-benzenesulfonyl chloride 2-naphthalenesulfonylchloride, 4-chloro- benzenesulfonyl chloride, 2,5-dichlorobenzenesulfonyl chloride, 1- naphthalenesulfonylchloride, 4-terf-butylbenzenesulfonyl chloride, 3-(trifluoromethyl)- benzenesulfonyl chloride, 2-bromobenzenesulfonyl chloride, 2-(trifluoromethyl)- benzenesulfonyl chloride, 3,4-dichlorobenzenesulfonyl chloride, 3,4- dimethoxybenzenesulfonyl chloride, 3-chlorobenzenesulfonyl chloride, 2-chloro-4- fluorobenzenesulfonyl chloride, 3,5-dichlorobenzenesulfonyl chloride, 3-chloro-4- fluorobenzenesulfonyl chloride, 2,4-dichlorobenzenesulfonyl chloride, 2,5- dimethoxybenzenesulfonyl chloride, 3-bromobenzenesulfonyl chloride, 2,3- dichlorobenzenesulfonyl chloride, 5-fluoro-2-methylbenzenesulfonyl chloride, 3- fluorobenzenesulfonyl chloride, 2,3,5,6-tetramethylbenzenesulfonyl chloride, 3-chloro- 2-methylbenzenesulfonyl chloride, 2,5-dibromo-3,6-difluorobenzenesulfonyl chloride, 2,6-difluorobenzenesulfonyl chloride, 2-chlorobenzenesulfonyl chloride, 5-bromo-2- methoxybenzenesulfonyl chloride, 5-chloro-2-methoxybenzenesulfonyl chloride, 2,4- difluorobenzenesulfonyl chloride, 2-cyanobenzenesulfonyl chloride, 2-chloro-5- (trifluoromethyl)-benzenesulfonyl chloride, 4-bromomethylbenzenesulfonyl chloride,

2,4-dimethoxybenzenesulfonyl chloride, 4-chloro-3-nitrobenzenesulfonyl chloride, 4- (chlorosulfonyl)-benzoic acid, 3-nitrobenzenesulfonyl chloride, 4-nitrobenzenesulfonyl chloride, 2-(methylsulfonyl)-benzenesulfonyl chloride, 4-(methylsulfonyl)- benzenesulfonyl chloride, 3-(chlorosulfonyl)-benzoic acid, 2,4-dichloro-5- methylbenzenesulfonyl chloride, 4-(trifluoromethoxy)-benzenesulfonyl chloride, 2- methoxy-4-nitrobenzenesulfonyl chloride, 4-bromo-2-chlorobenzene-sulfonyl chloride, 2,3-dihydro-1-benzofuran-5-sulfonyl chloride, 2,3-dihydro-1 ,4-benzodioxine-6-sulfonyl chloride, 1 ,3-benzothiazole-6-sulfonyl chloride, 2,1 ,3-benzothiadiazole4sulfonyl chloride, 2,1 ,3-benzothiadiazole-5-sulfonyl chloride, 2,1 ,3-benzoxadiazole-4-sulfonyl chloride, 3,4-dihydro-2H-1 ,5-benzodioxepine-7-sulfonyl chloride, 4-methyl-3,4-dihydro- 2H-1 ,4-benzoxazine-7-sulfonyl chloride, 4-(1 ,3-oxazol-5-yl)benzenesulfonyl chloride, 4-(1 ,2,3-thiadiazol-4-yl)benzenesulfonyl chloride, 4-(1 H-pyrazol-1-yl)benzenesulfonyl chloride, 4-(3-chloro-2-cyano-phenoxy)benzene-1-sulfonyl chloride, 5-chlorosulfonyl-2- hydroxybenzoic acid, 4-bromo-2,5-difluorobenzene-1-sulfonyl chloride, 4- (Acetylamino)-3-chlorobenzene-1-sulfonyl chloride, 3,5-di-(trifluoromethyl)-benzene-1- sulfonyl chloride, 2-fluorobenzenesulfonyl chloride, 4-methyl-3-nitrobenzene-1-sulfonyl chloride, 5-chloro-2,1 ,3-benzoxadiazole-4-sulfonyl chloride, 3-(5-methyl-1 ,3,4- oxadiazol-2-yl)-benzenesulfonyl chloride, methyl 3-(chlorosulfonyl)-4-methoxy- benzoate, 4-bromo-2-(trifluoromethyl)-benzenesulfonyl chloride, 2,2-dimethyl-6- chromanesulfonyl chloride, 4-(morpholine-4-sulfonyl)benzenesulfonyl chloride, 4- (pyrrolidine-1 -sulfonyl)-benzenesulfonyl chloride, 3-(2-methyl-4-pyrimidinyl)benzene- sulfonyl chloride, 2-cyano-5-methylbenzenesulfonyl chloride, 2,5-dimethylbenzene- sulfonyl chloride, 4-chloro-3-(trifluoromethyl)-benzenesulfonyl chloride, 4-bromo-2- methylbenzene-1-sulfonyl chloride, 2-chloro-4-(trifluoromethyl)-benzene-1-sulfonyl chloride, 2-chloro-4-cyanobenzene-1-sulfonyl chloride, 2,6-dichloro-4-(trifluoro- methyl)benzene-1-sulfonyl chloride, 3,4-difluorobenzene-1-sulfonyl chloride, 2- lodobenzene-1-sulfonyl chloride, 4-methyl-1-naphthalenesulfonyl chloride, 4- (trifluoromethyl)benzene-i-sulfonyl chloride, 2,6-dichlorobenzene-1-sulfonyl chloride, 2- (trifluoromethoxy)benzene-i-sulfonyl chloride, 4-cyanobenzene-1-sulfonyl chloride, 4- butoxybenzene-1-sulfonyl chloride, 2,3,4-trifluorobenzene-1-sulfonyl chloride, 4-bromo- 2-(trifluoromethoxy)-benzene-1-sulfonyl chloride, 3-cyanobenzene-1-sulfonyl chloride, 3-chloro-4-methylbenzene-1 -sulfonyl chloride, 4-bromo-2-ethylbenzene-1 -sulfonyl chloride, 5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenesulfonyl chloride, 4-(2- chloro-6-nitrophenoxy)benzene-1 -sulfonyl chloride, 3,5-dichloro-4-(2-chloro-4- nitrophenoxy)-benzene-1 -sulfonyl chloride, 4-pentylbenzene-1 -sulfonyl chloride, 4-

ethylbenzene-1-sulfonyl chloride, 4-propylbenzene-1-sulfonyl chloride, 4-butylbenzene- 1-sulfonyl chloride, 3-toluenesulfonyl chloride, 4-isopropylbenzene-sulfonyl chloride, 4- (2-0X0-1 -pyrrolidinyl)benzene sulfonyl chloride, 4-(2-Methoxyphenoxy)benzenesulfonyl chloride, 4-(2-chlorophenoxy)benzenesulfonyl chloride, 4-(2-methylphenoxy)- benzenesulfonyl chloride, 4'-Chloro(1 ,1'-biphenyl)-4-sulfonyl chloride, 4'-Fluoro(1 ,V- biphenyl)-4-sulfonyl chloride, 4'-Methoxy-(1 ,1 '-biphenyl)-4-sulfonyl chloride, 3', 4'- Dichloro-(1 ,1 '-biphenyl)-4-sulfonyl chloride, 4-phenoxybenzenesulfonyl chloride, 4'- Methyl-(1 , 1 '-biphenyl)-4-sulfonyl chloride, 5-bromo-2,3-dihydrobenzo[b]furan-7- sulphonyl chloride, 3,4,5-Trifluorobenzenesulfonyl chloride, 3-(5-methyl-1 ,2,4- oxadiazol-3-yl)benzenesulfonyl chloride, 4-(2-methyl-1 ,3-thiazol-4-yl)benzenesulfonyl chloride, 1-acetyl-5-indolinesulfonyl chloride, 3-(2-methyl-1 ,3-thiazol-4-yl)benzene- sulfonyl chloride and 1 ,3-benzodioxole-5-sulfonyl chloride.

Heterocylcylsulfonyl chloride that may be used as precursors in scheme 3 of figure 2 include for example, but are not limited to, commercially available products such as, 4-methyl-2-[3-(pentyloxy)phenyl]-5-Thiazolesulfonyl chloride, 2-(5-chloro-2- propoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-chloro-4-ethoxy-5- methoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-chloro-4,5-dimethoxy- phenyl)-4-methyl-5-thiazolesulfonyl chloride, 2-(2-methoxy-1-naphthalenyl)-4-methyl-5- Thiazolesulfonyl chloride, 2-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]- 4-methyl- 5-Thiazolesulfonyl chloride, 2-[4-[3-(dimethylamino)propoxy]phenyl]-4-methyl-5- Thiazolesulfonyl chloride, 2-[3-(hexyloxy)phenyl]-4-methyl-5-Thiazolesulfonyl chloride, 2-(5-bromo-2-ethoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-(2-butoxy-3- methoxyphenyl)-4-methyl-5-thiazolesulfonyl chloride, 2-[2-[2-(dimethyl-amino)ethoxy]- 3-methoxyphenyl]-4-methyl-5-thiazolesulfonyl chloride, 2-[2-[2-(dimethylamino)ethoxy]- 4-methoxyphenyl]-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-ethoxy-4-methoxyphenyl)- 4-methyl-5-thiazolesulfonyl chloride, 2-(3,4-diethoxy-phenyl)-4-methyl-5- thiazolesulfonyl chloride, 2-(2-butoxy-4-methoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-[4-(hexyloxy)phenyl]-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-ethoxy-4- propoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-[3-[2- (diethylamino)ethoxy]phenyl]-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-chloro-5- ethoxy-4-methoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride, 2-(3-methoxy-2- propoxyphenyl)-4-methyl-5-thiazolesulfonyl chloride, 4-methyl-2-[2-(2-phenylethoxy)- phenyl]-5-thiazolesulfonyl chloride, 2-[4-methoxy-2-(pentyloxy)phenyl]-4-methyl-5- thiazolesulfonyl chloride, 2-[3-methoxy-4-(pentyloxy)phenyl]-4-methyl-5-thiazole- sulfonyl chloride, 2-(3-methoxy-4-propoxyphenyl)-4-methyl-5-Thiazolesulfonyl chloride,

2-(3-bromo-4-hydroxy-5-methoxyphenyl)-4-methyl-5-Thiazole sulfonyl chloride, 5- (chlorosulfonyl)-2-Thiopheneacetic acid methyl ester, 5-[[(2,2,2- trifluoroacetyl)amino]methyl]-2-thiophenesulfonyl chloride, 5-[2-[(2,2,2-trifluoroacetyl)- amino]ethyl]-2-Thiophenesulfonyl chloride, 5-formyl-2-Thiophenesulfonyl chloride, 5-(3- amino-3-oxo-1-propen-1-yl)- 2-Thiophenesulfonyl chloride, 5-(2H-tetrazol-5-yl)- 2- Thiophenesulfonyl chloride, 5-(5-isoxazolyl)-2-methyl-3-Furansulfonyl chloride, 3-(1 ,3- dioxolan-2-yl)-2-Furansulfonyl chloride, 5-(chlorosulfonyl)-3-Thiophenecarboxylic acid, 4-[2-(methylthio)-4-pyrimidinyl]-2-Thiophenesulfonyl chloride, 5-(1 ,3-dioxolan-2-yl)-2- Thiophenesulfonyl chloride, 5-(chlorosulfonyl)-2-Thiopheneacetic acid, 5- (acetamidomethyl)-2-Thiophenesulfonyl chloride, 5-(chlorosulfonyl)-3-methyl-2,4- Thiophenedicarboxylic acid dimethyl ester, 4-phenyl-5-(trifluoromethyl)-3- Thiophenesulfonyl chloride, 5-(5-isoxazolyl)-2-Furansulfonyl chloride, 5-(5- lsoxazolyl)thiophene-2-sulfonyl chloride, 3-(chlorosulfonyl)-4-[(1 -methylethyl)sulfonyl]- 2-Thiophenecarboxylic acid methyl ester, 5-Chlorosulfonyl-4-methylthiophene-2- carboxylic acid methyl ester, 5-[5-(chloromethyl)-1 ,2,4-oxadiazol-3-yl]-2- thiophenesulfonyl chloride, 5-[(3-chloro-5-trifluoromethylpyridin-2-yl)methyl]-thiophene - 2-sulfonyl chloride, 5-(1 ,2,3-thiadiazol-4-yl)-2-thiophenesulfonyl chloride, 5-(5-chloro- 1 ,2,4-thiadiazol-3-yl)-2-Thiophenesulfonyl chloride, 5-(chlorosulfonyl)-2-methyl-3- Furancarboxylic acid methyl ester, 4-(chlorosulfonyl)-2,5-dimethyl-3-Furancarboxylic acid methyl ester, 4-(chlorosulfonyl)-2,5-dimethyl-3-Furancarboxylic acid ethyl ester, 5- (4-chlorophenyl)-4-(chlorosulfonyl)-2-methyl-3-Furancarboxyl ic acid ethyl ester, 3- (chlorosulfonyl^-phenyl-S-^rifluoromethyl^-Thiophenecarboxyl ic acid methyl ester, 5-Methyl-2-trifluoromethylfuran-3-sulfonyl chloride, 5-(2-Methyl-5-trifluoromethyl-2H- pyrazol-3-yl)thiophene-2-sulfonyl chloride, 5-(2-M ethyl- 1 ,3-thiazol-4-yl)thiophene-2- sulfonyl chloride, 3-Bromo-5-chloro-2-thiophenesulfonyl chloride, 5-(chlorosulfonyl)-4- methoxy-3-Thiophenecarboxylic acid methyl ester, 5-(2-Methylsulfanylpyrimidin-4- yl)thiophene-2-sulfonyl chloride, 3-Bromothiophene-2-sulfonyl chloride, 5- (Benzenesulfonyl)thiophene-2-sulfonyl chloride, 5-[[3-chloro-5-(trifluoromethyl)-2- pyridinyl]sulfonyl]-2-Thiophenesulfonyl chloride, 3-Bromo-2,5-dichlorothiophene-4- sulfonyl chloride, 4-Bromo-5-chlorothiophene-2-sulfonyl chloride, 5-(((4- Chlorobenzoyl)amino)methyl)-2-thiophenesulfonyl chloride, 2-[1-Methyl-5-

(trifluoromethyl)-3-pyrazolyl]thiophene-5-sulfonyl chloride, 2,5-Dimethylfuran-3-sulfonyl chloride, 2-Phenylthiophene-3-sulfonyl chloride, 4-(phenylsulfonyl)-2-Thiophenesulfonyl chloride, 2-(lsoxazol-3-yl)thiophene-5-sulfonyl chloride, 3-Quinolinesulfonyl chloride, Dimethyl 3-chlorosulfonyl-2,5-thiophenedicarboxylate, 4-Chloro-3-quinolinesulfonyl

chloride, 2-(2-Pyridyl)thiophene-5-sulfonyl chloride, 2-(Benzoylaminomethyl)thiophene- 5-sulfonyl chloride, 5-chloro-3-(chlorosulfonyl)-2-Thiophenecarboxylic acid methyl ester, 2,3-Dichlorothiophene-5-sulfonyl chloride, 4-Bromo-3-thiophenesulfonyl chloride, 3-(1 ,3-dioxolan-2-yl)-2-Thiophenesulfonyl chloride, 2,5-dimethylthiophene-3-sulfonyl chloride, 2-chlorosulfonyl-5-phenyl-thiophene, 2,3-dibromothiophene-5-sulfonyl chloride, 2,5-dibromo-3-thiophene-sulfonyl chloride, 2,5-dichloro-4-nitro-3- thiophenesulfonyl chloride, 4-(chlorosulfonyl)-3-thiophenecarboxylic acid methyl ester, 5-chloro-4-nitro-2-thiophenesulfonyl chloride, 2,4,5-Trichloro-3-thiophenesulfonyl chloride, 5-Ethyl-2-thiophenesulfonyl chloride, 5-(dichloromethyl)-2-Furansulfonyl chloride, 5-lodo-2-thiophenesulfonyl chloride, 5-bromo-2-Thiophenesulfonyl chloride, 1 ,4-dimethyl-1 H-lmidazole-2-sulfonyl chloride, 2-(chlorosulfonyl)-1-methyl-1 H- lmidazole-5-carboxylic acid methyl ester, 1 ,5-dimethyl-1 H-lmidazole-2-sulfonyl chloride, 3-chloro-5-(2,2,2-trichloroacetyl)- 1 H-Pyrrole-2-sulfonyl chloride, 2,3-dihydro- 2-methyl-1-(methylsulfonyl)- 1 H-lndole-5-sulfonyl chloride, 2-methyl-1- Piperidinesulfonyl chloride, 5-(2H-tetrazol-5-yl)-1 H-Pyrrole-2-sulfonyl chloride, 1- (chlorosulfonyl)-4-Piperidine-carboxylic acid methyl ester, 3,5-dimethyl-1- Piperidinesulfonyl chloride, 5-bromo-3-Pyridinesulfonyl chloride, 5-chloro-3-cyano-4,6- dimethyl-2-Pyridinesulfonyl chloride, 6-chloro-4-methyl-3-Pyridinesulfonyl chloride, 6- Chloro-2-methylpyridine-3-sulfonyl chloride, 3-bromo-4-Pyridinesulfonyl chloride, 6- bromo-3-Pyridinesulfonyl chloride, 3,5-dichloro- 2-Pyridinesulfonyl chloride, 3- (phenylmethoxy)-2-Pyridinesulfonyl chloride, 5-chloro-2-Pyridinesulfonyl chloride, 6- phenyl-3-Pyridinesulfonyl chloride, 1-methyl-5-(trichloroacetyl)-1 H-Pyrrole-3-sulfonyl chloride, 5-(trichloroacetyl)-1 H-Pyrrole-3-sulfonyl chloride, 1 ,2-dimethyl-1 H-lmidazole- 5-sulfonyl chloride, 1-(chlorosulfonyl)-3-Piperidinecarboxylic acid ethyl ester, 1- (chlorosulfonyl^-Piperidinecarboxylic acid ethyl ester, 3-chloro-1 ,5-dimethyl-1 H- pyrazole-4-sulfonyl chloride, 3-methyl-1 -piperidinesulfonyl chloride, 1-methyl-3- (trifluoromethyl)-1 H-pyrazole-4-sulfonyl chloride, 1-Methylimidazol-5-ylsulfonyl chloride, 2-(4-morpholinyl)- 3-Pyridinesulfonyl chloride, 5-Fluoro-2-chlorosulfonyl-3- methylbenzo[b]thiophene, 6-Phenoxypyridine-3-sulfonyl chloride, 4-(Chlorosulfonyl)- 3,5-dimethyl-1 H-pyrrole-2-carboxylic acid ethyl ester, 5-Methyl-1-phenyl-1 H-pyrazole-4- sulfonyl chloride, 4-methyl- 2-Pyridinesulfonyl chloride, 5-bromo-3-methyl- Benzo[b]thiophene-2-sulfonyl chloride, 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1 H- pyrrole-2-sulfonyl chloride, 6-(Morpholin-4-yl)pyridine-3-sulfonyl chloride, 6- methoxypyridine-3-sulfonyl chloride, 5-(chlorosulfonyl)-1-methyl-1 H-Pyrrole-2- carboxylic acid methyl ester, 3-(chlorosulfonyl)-4-Pyridinecarboxylic acid ethyl ester, 1-

methyl-1 H-pyrazole-4-sulfonyl chloride, Benzyl 4-(chlorosulfonyl)-1- piperidinecarboxylate, 6-methyl-2-Pyridinesulfonyl chloride, 2,6-dichloro- 3- Pyridinesulfonyl chloride, S-Bromo^-chloropyridine-δ-sulfonyl chloride, 5-methyl-2- pyridinesulfonyl chloride, 5-nitro-2-pyridinesulfonyl chloride, 5-(trifluoro-methyl)pyridine- 2-sulfonyl chloride, 5-chloro-2-(chlorosulfonyl)-3-methylbenzo[b]-thiophene, 1 ,2- Dimethyl-1 H-imidazole-4-sulfonyl chloride, 5-chloro-1-methyl-1 H-lmidazole-4-sulfonyl chloride, 6-Chlorobenzo[b]thiophene-2-sulfonyl chloride, 4-chloro-Benzo[b]thiophene-2- sulfonyl chloride, 2-Pyridinesulfonyl chloride, 5,6-Dichloro-3-pyridinesulfonyl chloride, Ethyl 3-(chlorosulfonyl)-1-methylpyrazole-4-carboxylate, 5-methyl-Benzo[b]thiophene- 2-sulfonyl chloride, 1-Benzothiophene-2-sulfonyl chloride, 1 ,3-dimethyl-1 H-Pyrazole-4- sulfonyl chloride, 1-Methyl-1 H-pyrazole-3-sulfonyl chloride, 5-Chloro-1 ,3-dimethyl-1 H- pyrazole-4-sulfonyl chloride, 3,5-dimethyl- Pyrazole-4-sulfonyl chloride, 5-Bromo-3- pyridinesulfonyl chloride, 3, 5-dimethyl-1 -phenyl- 1 H-Pyrazole-4-sulfonyl chloride, 3- Methylbenzo[b]thiophene-2-sulfonyl chloride, 1-Methyl-1 H-imidazole-2-sulfonyl chloride, 3-Pyridinesulfonyl chloride, 4-Methyl-1-piperidinesulfonyl chloride, 1- Piperidinesulfonyl chloride, 4-chloro- 3-Pyridinesulfonyl chloride, Benzo[b]thiophene-3- sulfonyl chloride, 5-(chlorosulfonyl)-1 ,3,4-Thiadiazole-2-acetic acid methyl ester, 3,4- dihydro-4-oxo-2H-1-Benzopyran-3-sulfonyl chloride, 4-lsoxazolesulfonyl chloride, 5- formyl-1 ,3,4-Thiadiazole-2-sulfonyl chloride, 5-methyl-1 H-lmidazole-2-sulfonyl chloride, 5-(chlorosulfonyl)-1 ,3,4-Thiadiazole-2-carboxylic acid methyl ester, 2,3-dihydro-2-oxo- 5-Thiazolesulfonyl chloride, 2,3-dihydro-4-methyl-2-oxo-5-Thiazolesulfonyl chloride, 6- amino-1 ,2,3,4-tetrahydro-1 ,3-dimethyl-2,4-dioxo-5-Pyrimidinesulfonyl chloride, 1 ,2,3,4- tetrahydro-1 ,3,6-trimethyl-2,4-dioxo-5-Pyrimidinesulfonyl chloride, 2,6-dimethyl-4- Morpholinesulfonyl chloride, 2,4-dimethyl-5-Pyrimidinesulfonyl chloride, 1 H-lndole-3- sulfonyl chloride , 5-methyl-3-phenyl- 4-lsoxazolesulfonyl chloride, 1 ,3,4-Thiadiazole-2- sulfonyl chloride, 5-methyl- 4-lsoxazolesulfonyl chloride, 1 H-lmidazole-2-sulfonyl chloride, 2-methyl-1 H-lmidazole-5-sulfonyl chloride, 3,4-Dihydro-1 H-isoquinoline-2- sulfonyl chloride, 3-(Chlorosulfonyl)-4-methyl-3-thiolene 1 ,1 -dioxide, 1 ,2,3,4-tetrahydro- 1 ,3-dimethyl-2,4-dioxo-5-Pyrimidinesulfonyl chloride, 4-chloro-tetrahydro-3- Thiophenesulfonyl chloride 1 ,1 -dioxide, 3-(Chlorosulfonyl)-3-thiolene 1 ,1 -dioxide, tetrahydro-4-hydroxy-3-Thiophenesulfonyl chloride 1 ,1 -dioxide, 3,5-dimethyl-4- Isoxazolesulfonyl chloride, 4,5,6,7-tetrahydro-5-methyl-thiazolo[5,4-c]pyridine-2- sulfonyl chloride, 4,5,6,7-tetrahydro-5-(2,2,2-trifluoroacetyl)-Thiazolo[5,4-c] pyridine-2- sulfonyl chloride, and 2-(chlorosulfonyl)-4,7-dihydro-Thieno[2,3-c]pyridine-6(5H)- carboxylic acid 1 ,1-dimethylethyl ester.

The above synthetic principles can also be applied similarly with aliphatic sulfonyl chlorides, such as alkyl-, cycloalkyl-, cycloalkyl-alkyl-, arylalkyl-, and arylalkenyl-sulfonyl chlorides. The above synthetic principles can also be applied similarly with a higher analogue of piperazine, e.g. homopiperazine.

The above synthetic principles can also be applied similarly when a divalent group (G), such as divalent group derived from an optionally substituted piperidine, is present in the final compounds instead of a divalent group (A'), i.e. when a thiazolyl derivative reprsented by the structural formula (IV) has to be produced.

Exemplary derivatives of this class are shown in table 1 below with their chemical formula, the value of EC50 (expressed in nM) and the percentage inhibition (%l) in a biological assay as explained in examples 3 and 4.

Table 1

(end of Table 1 )

All stereoisomers or enantiomers thereof, or a solvate thereof, or a λ/-oxide thereof, or a pharmaceutically acceptable salt thereof, are also embraced within the present invention.

Example 1 - Construction of an α-svnuclein over-expressing cell line

An α-synuclein expression plasmid was constructed by sub-cloning the Ncol/Xhol fragment from 212T-SYN(WT) (Griffioen et al., Biochem Biophys Acta (2006) 1762(3):312-318) containing the cDNA of human wild type α-synuclein correspondingly into a standard mammalian expression vector pcDNA3.1 resulting in plasmid pcDNA3.1-SYNwt. Plasmid pcDNA3.1 and pcDNA3.1-SYNwt were transfected to human neuroblastoma cells (ATCC No. CRL-2267) and independent clonal lines with the plasmids stably integrated into the genome were selected. These resulted in cell lines named M17 (transfected with pcDNA3.1 ) and M17-SYNwt (transfected with pcDNA3.1-SYNwt). Over-expression of α-synuclein in M17-SYNwt cell lines was confirmed by Western analysis.

Example 2 - use of α-svnuclein expressing cells as a model for neuronal degradation

Due to the high levels of α-synuclein M17-SYNwt cells are exquisitely sensitivity to paraquat, a well-known risk factor of synuclein-dependent neuronal degeneration. In degenerated or dead cells lactate dehydrogenase (LDH) is leaked out of the cells into the extracellular environment due to a loss of plasma-membrane integrity. This principle was used to determine cytotoxicity by quantifying the level of leaked LDH into the growth medium.

The detailed method for determining α-synuclein cytotoxicity was as follows: From appropriate precultures of M17 and M17-SYN cells were seeded at 50000 cells/cm ² in Optimem Reduced Serum without phenol red (InVitrogen, Cat. 31985-047) supplemented with 5% fetal calf serum, 1 mM sodium pyruvate, 1 x non-essential amino acids, 500 μg/ml G418 0,5 x antibiotic/antimycotic. After 3 hours of incubation at 37°C/5% CO ₂ paraquat was added to the cells (final concentration of 32 mM), together with the test compound and the cells were further incubated for 40 hours. Subsequently, LDH activity was determined using Promega Cytotox 96 Non- Radioactive cytotoxicity assay, (Cat. G1780) according the supplier's instructions.

Figure 1 shows that treatment of M17-SYNwt cells, but not of M17 cells with paraquat led to a relatively high level of LDH leaked into the medium demonstrating that α-synuclein mediates cellular degeneration or cell death in response to paraquat.

Example 3 - use of the α-svnuclein expressing cells in the screening compounds

This α-synuclein expressing neuroblastoma cells made it possible to assess the ability of novel compounds to counteract α-synuclein cytotoxicity. Active inhibitors of α-synuclein cytotoxicity were found to provoke a decrease of LDH leakage in paraquat-treated M17-SYNwt cells. Since this method monitors leaked LDH from degenerated or dead cells only non-toxic compounds will be identified as active inhibitors of α-synuclein-mediated cytotoxicity. Lack of toxicity is an important characteristic for compounds to be used as a medicament to patients in need. A compound was considered to be active in this test when it inhibits α-synuclein cytotoxicity by more than 25% relative to untreated M17-SYNwt cells at a concentration of 20 μg/mL or lower. In the experiments, the control group consisted of M17-SYNwt cells treated with DMSO, the untreated paraquat group consisted of M17-SYNwt cells treated with paraquat and DMSO, and the treated paraquat group consisted of M17- SYNwt cells treated with paraquat and the test compound dissolved in DMSO.

In order to determine EC ₅₀ compounds were tested at different concentrations ranging from non-effective (thus at a relatively low concentration) to an effective

(relatively high) concentration of test compound. These data were also used for calculation of percent inhibition (% I). Percent inhibition was calculated as the synu- clein toxicity inhibition by the compound in treated paraquat cells, relative to the synuclein cytotoxicity in untreated paraquat cells. This corresponds to the following equation:

(LDH release of treated paraquat cells at non-effective concentration of test cmpd) - (LDH release of treated paraquat cells at most effective concentration of test cmpd) / (LDH release of untreated paraquat cells) - (LDH release control cells) ^* 100%

Example 4 - inhibition of svnuclein-mediated toxicity

The compounds from table 1 were screened for activity using the α-synuclein cytotoxicity assay as described above. Dose responses were carried out on all compounds found to be active (10 point curves in duplicate). Although the pharmacological properties of the compounds disclosed in this invention vary with structural change as expected, active compounds most particularly possess EC ₅₀ in a cell-based assay of synuclein cytotoxicity in a range from about 0.0001 to 10 μM.

Example 5 - in vivo inhibition of svnuclein-mediated instigated loss of substantia nigra neurons In order to model neuronal loss in the substantia nigra region of the brain, mice are treated with paraquat (intraperitoneal) at a dose not higher than 8 mg/kg/day for a continuous period of 15-100 days. These mice are also chronically co-treated during that period with a compound from table 1 administered at a dose not higher than 20 mg/kg body weight/day), or by vehicle only (no active compound). Mice treatment by means of vehicle or a compound of the invention start 2 days before administration of paraquat.

At the end of the treatment period, mice are sacrificed and the corresponding brains are used for immunohistochemical analysis. The substantia nigra brain region has a relatively high percentage of cells with high levels of tyrosine hydroxylase. Using antibodies raised against tyrosin hydroxylase (anti-tyrosin hydroxylase), tyrosine hydroxylase containing neurons in the brains are detected. Quantitative and comparative analysis of the tyrosin hydroxylase-positive stained substantia nigra areas reveal a significantly larger TH-positive area in mice treated with compound versus vehicle treated mice.

Example 6 - in vivo inhibition of 6-hydroxydopamine (6-OHDA) instigated loss of substantia nigra neurons

Unilateral substantia nigra lesions are obtained by stereotactic striatal injections of 6-hydroxydopamine in brains of living rats as described by Vercammen et al. in Molecular Therapy, 14(5) 716-723 (2006). These rats are also chronically co-treated with a compound of table 1 and at the same dose as mentioned in example 5, or by vehicle only (no active compound). Daily treatment of compound or vehicle is started preferably 1 or 2 days before administration of 6-OHDA and lasts between 7 to 30 days after the 6-OHDA injection. At the end of the treatment period, rats are sacrificed and the corresponding brains are used for immunohistochemical analysis. The substantia nigra brain region has a relatively high percentage of cells with high levels of tyrosine hydroxylase. Using antibodies raised against tyrosin hydroxylase (anti-tyrosine hydroxylase) tyrosine hydroxylase containing neurons in the brains are detected. The nigral lesion volumes and/or the tyrosine hydroxylase positive cell numbers are quantified as described in Vercammen et al. (cited supra). This analysis reveals that: the nigral lesion volumes are significantly reduced in rats treated with a compound according to this invention, as compared to vehicle treated rats, thus indicating that the compound is able to inhibit 6-OHDA triggered degeneration of substantia nigra cells in vivo; and tyrosine hydroxylase positive cell numbers are higher in rats treated with a compound according to this invention as compared to vehicle treated rats, thus providing confirmation that the compound is able to inhibit 6-OHDA triggered degeneration of substantia nigra cells in vivo.

Example 7 - in vitro inhibition of α-synuclein aggregation α-synucleinopathies are characterised by aggregation of α-synuclein in neurons. Aggregation of purified α-synuclein is performed essentially as described by Gerard et al. FASEB. 20(3):524-6 (2006). 20-100 μg purified α-synuclein (Sigma; S7820) at a concentration of about 2.5 μg/mL is incubated in the presence of spermin (250 μM) or paraquat (32 mM) or 6-hydroxydopamine (400 μM) or vehicle in a 384 well plate. Spermin, paraquat and 6-hydroxydopamine promote the α-synuclein aggregation process. Aggregation kinetics is determined by measuring turbidity at 340 nm, every 1- 15 minutes for at least one hour. The same compounds of table 1 , or vehicle only, is added to the different α-synuclein mixtures described above. This analysis reveals that,

when a compound is present, the measured turbidity is lower compared to reactions containing vehicle only. This finding shows that the compound is able to inhibit aggregation of α-synuclein.

Example 8 - preparation of compound 1 and analogues thereof

Using the synthetic scheme shown in figure 2 (wherein W is a single bond), compound 1 (i.e. 1-[4-(4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)-sulfonyl]- piperazine) shown in table 1 has been synthesised in good yield starting from 4'- fluoroacetophenone, piperazine and (4-methoxyphenyl)sulfonyl chloride. Using the same synthetic procedure but replacing 4'-fluoroacetophenone with another alkylarylketone, the following derivatives of this invention are prepared: 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]- piperazine, and 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methoxyphenyl)sulfonyl]-piperazine.

Example 9 - preparation of derivatives of the invention wherein W is a single bond

Using the same synthetic procedure (figure 2) and the same alkylarylketones as in example 8, but replacing (4-methoxyphenyl)sulfonyl chloride with another arylsulfonylchloride, the following derivatives are prepared: 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]-pi perazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]-pi perazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]- piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1 -[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine 1 -[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propyl phenyl )sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propyl phenyl )sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propyl phenyl )sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine

^^-(^ethoxyphenyO-i ^-thiazol^-ylH-^^-dichlorophenyOsulfonyO-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine 1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine 1 -[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-phenyl-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methyl phenyl )sulfonyl]-piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine 1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine 1 -[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine 1 -[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]-piper azine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]-piper azine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]-pipe razine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]-pipe razine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]-piperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine 1 -[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine 1 -[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1 -[4-(4-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1 -[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine 1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-phenyl-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]-p iperazine

1-[4-(2-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(3-methoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

^[^(^methoxyphenyO-i ^-thiazol^-yO^-^^-dichloro-δ-methylphenyOsulfonyl]- piperazine

1-[4-(4-methylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(4-ethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-ethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-propylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methyl phenyl )sulfonyl]- piperazine

1-[4-(2,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,5-dimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-4-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5- methylphenyl)sulfonyl]-piperazine

1-[4-(3-chloro-5-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5- methylphenyl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorophenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5- methylphenyl)sulfonyl]-piperazine

1-[4-(3,4,5-trimethoxyphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1-[4-(piridin-2-yl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine

1-[4-(thien-3-yl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine

1-[4-(piridin-2-yl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-4-nitrothiophen-2-yl)sulfonyl] -piperazine

1-[4-(thien-3-yl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-4-nitrothiophen-2-yl)sulfonyl] -piperazine

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-4-nitrothiophen-2-yl)sulfonyl] - piperazine

1-[4-(piridin-2-yl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]-piperazin e

1-[4-(thien-3-yl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]-piperazin e

1-[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]-piperazin e

1 -[4-(piridin-2-yl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]-piperazine 1 -[4-(thien-3-yl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]-piperazine

1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]- piperazine

1-[4-(piridin-2-yl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]-pi perazine

1 -[4-(thien-3-yl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]-pi perazine, and 1 -[4-(2,4,6-trimethylphenyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]- piperazine.

Example 10 - preparation of derivatives of the invention wherein W is methylene, bis- methylene or ethylidene

1 -[4-(4-methylbenzyl-1 ,3-thiazol-2-yl]-4-[(4-propylphenyl)sulfonyl]-piperazine is prepared using the synthetic scheme shown in figure 2 (wherein W is methylene), starting from 4-methylbenzylmagnesium chloride, piperazine and 4-propylbenzene-1- sulfonyl chloride. Using the same procedure, the following compounds are prepared:

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-fluorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-methylphenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chlorophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]-pi perazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]-pi perazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(trifluoromethoxy)phenyl)sulfonyl]- piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-tert-butylphenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(pentafluorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]-piperaz ine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-trimethylphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine 1 -[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]-pi perazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4,6-tri-iso-propylphenyl)sulfonyl]- piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dichlorophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]-piperazin e 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dimethoxyphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3,5-dichlorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3-dichlorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,6-difluorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-difluorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]-piperaz ine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine 1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-(bromomethyl)phenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1 -[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]-pip erazine 1 -[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-(trifluoromethyl)phenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-nitrophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-bromophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chlorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine ^^-(S-chloro-δ-fluorobenzyO-i ^-thiazol^-yO^-^-cyanophenyOsulfonyO-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-cyanophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-nitrophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chlorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-bromophenyl)sulfonyl]-piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine 1 -[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-fluorophenyl)sulfonyl]-piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(3-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-4-fluorophenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine 1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-2-methylphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine 1 -[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine 1 -[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]-piper azine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-fluoro-2-methylphenyl)sulfonyl]- piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]-pip erazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,3,5,6-tetramethylphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine 1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6-difluorophenyl)sulfonyl ]- piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,5-dibromo-3,6- difluorophenyl)sulfonyl]-piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]-piper azine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]-piper azine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-bromo-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine 1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine 1 -[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]-pipera zine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-bromo-2-chlorophenyl)sulfonyl]- piperazine 1 -[4-benzyl-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]-pipe razine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]-pipe razine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

^^-(S^-dichlorobenzyO-i ^-thiazol^-yll^-^δ-chloro^-methoxyphenyOsulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1 -[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-2-methoxyphenyl)sulfonyl]- piperazine 1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]-piperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine 1 -[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine 1 -[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-(trifluoromethyl)phenyl)sulf onyl]- piperazine

1 -[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1 -[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1 -[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1 -[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5- (trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine 1 -[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2-chloro-5-

(trifluoromethyl)phenyl)sulfonyl]-piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine 1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine 1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]-pipera zine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine 1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(4-chloro-3-nitrophenyl)sulfonyl]- piperazine

1-[4-benzyl-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]-p iperazine

1-[4-(2-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(3-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-bromobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-chlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-methoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-methylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-ethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(4-ethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(4-propylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,6-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,3-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1-[4-(2,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(2,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1 -[4-(3,4-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-difluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dichlorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,5-dimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-4-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3-chloro-5-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-(3,4,5-trimethoxybenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine,

1-[4-(2,4,6-trimethylbenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine

1-[4-((4-methoxyphenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5- methylphenyl)sulfonyl]-piperazine

1-[4-((4-nitrophenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]- piperazine 1-[4-(phenylvinyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dichloro-5-methylphenyl)sulfonyl]-p iperazine

1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]- 4-[(5-chloro-4-nitrothiophen-2- yl)sulfonyl]-piperazine

1-[4-((4-methoxyphenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-4-nitrothiophen-2- yl)sulfonyl]-piperazine 1-[4-((4-nitrophenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(5-chloro-4-nitrothiophen-2-yl)sulfonyl] - piperazine

1 -[4-(phenylvinyl)-1 ,3-thiazol-2-yl]- 4-[(5-chloro-4-nitrothiophen-2-yl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]- piperazine 1 -[4-((4-methoxyphenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]- piperazine

1-[4-((4-nitrophenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(6-bromopyridin-3-yl)sulfonyl]-piperazin e

1 -[4-(phenylvinyl)-1 ,3-thiazol-2-yl]- 4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]-piperazine

1 -[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]- piperazine

1 -[4-((4-methoxyphenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]- piperazine

1 -[4-((4-nitrophenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]- piperazine 1 -[4-(phenylvinyl)-1 , 3-th iazol-2-y I]- 4-[(5-methyl-1 H-imidazol-2-yl)sulfonyl]-piperazine

1-[4-(4-chloro-3-fluorobenzyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]- piperazine

1-[4-((4-methoxyphenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]- piperazine

1-[4-((4-nitrophenyl)ethyl)-1 ,3-thiazol-2-yl]-4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]- piperazine, and

1 -[4-(phenylvinyl)-1 ,3-thiazol-2-yl]- 4-[(2,4-dimethylpyrimidin-5-yl)sulfonyl]-piperazine.

Example 12 - biological activity of some derivatives Exemplary compounds of this invention are shown in table 2 below with their chemical formula, the value of EC ₅₀ (expressed in nM) and the percentage inhibition (% inh.) in the biological assay of examples 3 and 4. The same compounds are also included in table 3 below with their official name according to IUPAC nomenclature.

Table 2

Table 3

derivatives Exemplary compounds of this invention are shown below with the chemical shifts (ppm), multiplicity and assignment of peaks present in their proton nuclear magnetic resonance (NMR) spectra.

Compound No.10

Compound No.11

Compound No.12

Compound No.13

Compound No. 14

Compound No. 15

Compound No. 16

Compound No. 17

Compound No.18

Compound No.19

Compound No.20

Compound No. 21

Compound No. 22

Compound No.23

Compound No.24

Compound No.25

Compound No.26

Compound No.27

Compound No.28

Compound No.29

Compound No.30

Compound No.31

Compound No.32

Compound No.47

Compound No.48

Compound No.49

Compound No.54

Compound No. 55

Compound No. 77

Example 14 - production of compound No. 26

The production of compound No. 26 proceeds according to the sequence of reaction steps shown in the following schemes:

1 ^z The first sub-step shown above was performed at 20 ⁰ C during 2 hours with a molar excess of CH ₂ N ₂ (about 2 molar equivalents) in dry ether, then in a second sub-step (shown below) performed at 5°C HCI gas was bubbled into the reaction mixture for 15 minutes, and the desired intermediate was obtained in 71 % yield.

For the conversion from 3 to 4, the first sub-step shown above was performed at 20 ⁰ C during 1 hour with a molar excess of thio-carbonyldiimidazole (about 2 molar equivalents) in THF, then in a second sub-step performed at 20 ⁰ C for 12 hours a 25% aqueous NH ₃ solution was added, and the desired intermediate was obtained in 72% yield. The conversion from 4 to 5 was performed during 6 hours with 1 molar equivalent NaHCO ₃ at reflux in methanol, and the desired intermediate was obtained in 92% yield. The conversion from 5 to 6 was performed during 3 hours at 20°C, and the desired intermediate was obtained in 90% yield.

The conversion from 6 to the final compound was performed during 6 hours at 20 ⁰ C in 1 ,2-dichloroethane (DCE) in the presence of a molar excess of triethylamine (1.2 molar equivalents).

Example 15 - production of compound No. 32

The production of compound No. 32 proceeds according to the sequence of reaction steps shown in the above scheme. The conversion from 9 to 11 was performed during 1 hour at 20 ⁰ C in dichloromethane (DCM), and the desired intermediate 11 was obtained in 86% yield. The conversion from 11 to 13 was performed during 2 hours at 20 ⁰ C in the presence of a molar excess of 12 (1.05 molar equivalents) and 3 molar equivalents potassium carbonate, and the desired intermediate 13 was obtained in 76% yield. The conversion from 13 to 14 was performed during 48 hours at 20°C in the presence of methanol, THF and aq. ammonium sulfide, and the desired intermediate 14 was obtained in 56% yield. The conversion from 14 to 15 was performed during 8 hours at reflux in ethanol, in the presence of a molar excess of 2 (1.3 molar equivalents) and 1.5 molar equivalents sodium hydrogenocarbonate.

Example 16 - production of compounds No. 19-25 and 27-31

The production of compounds No. 27-31 proceeds according to the same sequence of reaction steps as already shown in example 14, except that in the final step intermediate 7 was replaced with a substituted arylsulfonyl chloride. In this way: - compound No. 27 was obtained in 21% yield, compound No. 28 was obtained in 43% yield; compound No. 29 was obtained in 62% yield; compound No. 30 was obtained in 44% yield; and compound No. 31 was obtained in 59% yield. The production of compounds No. 19-25 proceeds according to the same sequence of reaction steps as already shown in example 14, except that in the final step intermediate 7 was replaced with an optionally substituted heteroarylsulfonyl chloride. In this way: compound No. 19 was obtained in 39% yield;

compound No. 20 was obtained in 52% yield; compound No. 21 was obtained in 41% yield; compound No. 23 was obtained in 77% yield; and compound No. 25 was obtained in 38% yield.

Example 17 - production of compound No. 49

The production of compound No. 49 proceeds according to the sequence of reaction steps shown in the following scheme:

The initial step is as described in example 14. Then the conversion from 5 to 25 was performed during 6 hours at reflux in methanol in the presence of a molar equivalent of 24 and a molar equivalent of sodium hydrogenocarbonate, and the desired intermediate 25 was obtained in 81 % yield. The conversion from 25 to 26 was performed during 3 hours at 20 ⁰ C in the presence of triethylamine, and the desired intermediate 26 was obtained in 73% yield. The conversion from 26 to the final compound No. 49 was performed during 6 hours at 20 ⁰ C in the presence of a molar excess of triethylamine.

Example 18 - production of compounds No. 54-55

The production of compound No. 54-55 proceeds according to the sequence of reaction steps shown in the following scheme:

The initial step is as described in example 14. Then the conversion from 5 to 30 was performed during 6 hours at reflux in ethanol in the presence of a molar equivalent of 29 and a molar equivalent of sodium hydrogenocarbonate, and the desired intermediate 30 was obtained in 79% yield. The conversion from 30 to 31 was performed during 3 hours at 20 ⁰ C, and the desired intermediate 31 was obtained in 91% yield. The conversion from 31 to the final compounds No. 54-55 was performed during 6 hours at 20 ⁰ C in the presence of a molar excess (1.1 molar equivalent) of triethylamine. In this way: - compound No. 54 was obtained in 50% yield; and compound No. 55 was obtained in 31% yield.