Title:
PHENYL-CONTAINING COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/008516
Kind Code:
A1
Abstract:
A phenyl-containing compound, an intermediate thereof, a preparation method therefor and an application thereof. Provided is a compound represented by formula I or a pharmaceutically acceptable salt thereof, where R 1, R 2, R 3, R 4 and R 5 are independently hydrogen, C 1-C 6 alkyl, C 1-C 6 alkoxy or C(=O)OR 8; where R 8 is C 1-C 4 alkyl; R 6 is (II), (III) or (IV); and R 7 is -OH, -NH 2, -NHCH 3, -N(CH 3) 2 or C 1-4 alkoxy. The compound has a low critical micelle concentration (CMC) and good dilution resistance and is capable of enclosing an insoluble drug to form a small-molecule micelle having a high drug loading capacity and good stability. (I)
Inventors:
HE JUN (CN)
WANG ZHEFENG (CN)
ZHAO YUEZHU (CN)
YANG YANI (CN)
FU QINGHUI (CN)
BIAN WEI (CN)
ZHAO YUAN (CN)
GE CHEN (CN)
ZHANG YUE (CN)
YI BING (CN)
NIU MINGHAO (CN)
ZHANG JIUHUI (CN)
WANG ZHEFENG (CN)
ZHAO YUEZHU (CN)
YANG YANI (CN)
FU QINGHUI (CN)
BIAN WEI (CN)
ZHAO YUAN (CN)
GE CHEN (CN)
ZHANG YUE (CN)
YI BING (CN)
NIU MINGHAO (CN)
ZHANG JIUHUI (CN)
Application Number:
PCT/CN2020/101842
Publication Date:
January 21, 2021
Filing Date:
July 14, 2020
Export Citation:
Assignee:
NATIONAL PHARMACEUTICAL ENGINEERING RES CENTER (CN)
SHANGHAI INST PHARMACEUTICAL IND (CN)
SHANGHAI INST PHARMACEUTICAL IND (CN)
International Classes:
C07C309/18; A61K9/107; A61K47/20; A61P35/00; A61P35/04; C07C68/00; C07C69/96; C07C303/22
Foreign References:
| CN1668583A | 2005-09-14 | |||
| CN101951956A | 2011-01-19 | |||
| CN101945671A | 2011-01-12 | |||
| EP2116524A1 | 2009-11-11 | |||
| US20080221349A1 | 2008-09-11 | |||
| CN201910650358A | 2019-07-18 | |||
| CN1668583A | 2005-09-14 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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