Title:
PHENYL UREA DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/250108
Kind Code:
A1
Abstract:
The present invention pertains to a therapeutic agent or preventative agent against diseases involving an orexin receptor, particularly an orexin type-2 receptor, the agent containing a novel compound having a urea skeleton, or a pharmacologically acceptable salt thereof, as an active ingredient. Specifically, the present invention pertains to a therapeutic agent or preventative agent against diseases such as narcolepsy, idiopathic hypersomnia, hypersomnia, and sleep apnea syndrome.
Inventors:
KOMIYA MASAFUMI (JP)
UESUGI SHUNICHIRO (JP)
IDEUE EIJI (JP)
LEE SHOUKOU (JP)
TANAKA DAISUKE (JP)
FUNAKOSHI YUTA (JP)
UESUGI SHUNICHIRO (JP)
IDEUE EIJI (JP)
LEE SHOUKOU (JP)
TANAKA DAISUKE (JP)
FUNAKOSHI YUTA (JP)
Application Number:
PCT/JP2022/021531
Publication Date:
December 01, 2022
Filing Date:
May 26, 2022
Export Citation:
Assignee:
SUMITOMO PHARMA CO LTD (JP)
International Classes:
A61P1/02; A61K31/454; A61K31/4545; A61K31/496; A61K31/4995; A61K31/506; A61K31/5377; A61K31/55; A61K31/551; A61P1/08; A61P1/14; A61P1/16; A61P3/02; A61P3/04; A61P3/06; A61P3/10; A61P5/06; A61P5/24; A61P7/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/00; A61P15/00; A61P15/08; A61P19/02; A61P19/06; A61P19/08; A61P21/00; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/26; A61P25/28; A61P25/30; A61P27/02; A61P27/16; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D211/14; C07D211/18; C07D211/22; C07D211/26; C07D211/46; C07D211/64; C07D211/70; C07D221/04; C07D223/16; C07D243/08; C07D401/04; C07D401/12; C07D405/12; C07D413/04; C07D413/12; C07D413/14; C07D417/04; C07D451/02; C07D487/08
Domestic Patent References:
| WO2019199353A1 | 2019-10-17 | |||
| WO2006007864A1 | 2006-01-26 | |||
| WO2000035877A1 | 2000-06-22 | |||
| WO2022093780A1 | 2022-05-05 | |||
| WO2017135306A1 | 2017-08-10 |
Foreign References:
| JP2010155827A | 2010-07-15 | |||
| JP2008542276A | 2008-11-27 | |||
| JP2004517872A | 2004-06-17 | |||
| JP2010503676A | 2010-02-04 | |||
| JP2002532427A | 2002-10-02 |
Other References:
WANG QINGGANG, GALLARDO-MACIAS RICARDO, RASHMI, GOLOVKO MIKHAIL Y., ELSAYED AHMED ADHAM RAAFAT, MORE SHYAM K., ONCEL SEMA, GURVICH: "Discovery of Novel Small-Molecule FAK Activators Promoting Mucosal Healing", ACS MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 3, 11 March 2021 (2021-03-11), US , pages 356 - 364, XP093007595, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.0c00311
MEZEIOVA EVA, JANOCKOVA JANA, KONECNY JAN, KOBRLOVA TEREZA, BENKOVA MARKETA, DOLEZAL RAFAEL, PRCHAL LUKAS, KARASOVA-ZDAROVA JANA, : "From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia", BIOORGANIC CHEMISTRY, vol. 103, 1 October 2020 (2020-10-01), US , pages 1 - 10, XP055964326, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.104179
CELL, vol. 92, 1998, pages 573 - 585
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
CELL, vol. 98, 1999, pages 365 - 376
THE LANCET, vol. 355, 2000, pages 39 - 40
NEURON, vol. 38, 2003, pages 715 - 730
BRAIN, vol. 130, 2007, pages 1577 - 1585
NEUROSCIENCE LETTERS, vol. 569, 2014, pages 68 - 73
T. W. GREENE, AND P. G. M. WUTS.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
MEZEIOVA EVA, JANOCKOVA JANA, KONECNY JAN, KOBRLOVA TEREZA, BENKOVA MARKETA, DOLEZAL RAFAEL, PRCHAL LUKAS, KARASOVA-ZDAROVA JANA, : "From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia", BIOORGANIC CHEMISTRY, vol. 103, 1 October 2020 (2020-10-01), US , pages 1 - 10, XP055964326, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.104179
CELL, vol. 92, 1998, pages 573 - 585
PROC. NATL. ACAD. SCI. USA, vol. 101, 2004, pages 4649 - 4654
CELL, vol. 98, 1999, pages 365 - 376
THE LANCET, vol. 355, 2000, pages 39 - 40
NEURON, vol. 38, 2003, pages 715 - 730
BRAIN, vol. 130, 2007, pages 1577 - 1585
NEUROSCIENCE LETTERS, vol. 569, 2014, pages 68 - 73
T. W. GREENE, AND P. G. M. WUTS.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: