Title:
PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE MODULATORS
Document Type and Number:
WIPO Patent Application WO2004072031
Kind Code:
A3
Abstract:
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
Inventors:
FYFE MATTHEW COLIN THOR (GB)
GARDNER LISA SARAH (GB)
NAWANO MASAO (JP)
PROCTER MARTIN JAMES (GB)
RASAMISON CHRYSTELLE MARIE (GB)
SCHOFIELD KAREN LESLEY (GB)
SHAH VILASBEN KANJI (GB)
YASUDA KOSUKE (JP)
GARDNER LISA SARAH (GB)
NAWANO MASAO (JP)
PROCTER MARTIN JAMES (GB)
RASAMISON CHRYSTELLE MARIE (GB)
SCHOFIELD KAREN LESLEY (GB)
SHAH VILASBEN KANJI (GB)
YASUDA KOSUKE (JP)
Application Number:
PCT/US2004/003968
Publication Date:
December 02, 2004
Filing Date:
February 10, 2004
Export Citation:
Assignee:
OSI PHARM INC (US)
FYFE MATTHEW COLIN THOR (GB)
GARDNER LISA SARAH (GB)
NAWANO MASAO (JP)
PROCTER MARTIN JAMES (GB)
RASAMISON CHRYSTELLE MARIE (GB)
SCHOFIELD KAREN LESLEY (GB)
SHAH VILASBEN KANJI (GB)
YASUDA KOSUKE (JP)
FYFE MATTHEW COLIN THOR (GB)
GARDNER LISA SARAH (GB)
NAWANO MASAO (JP)
PROCTER MARTIN JAMES (GB)
RASAMISON CHRYSTELLE MARIE (GB)
SCHOFIELD KAREN LESLEY (GB)
SHAH VILASBEN KANJI (GB)
YASUDA KOSUKE (JP)
International Classes:
A61P3/10; C07D211/34; C07D213/55; C07D277/30; C07D277/40; C07D277/46; C07D307/54; C07D309/04; C07D309/08; C07D333/24; C07D333/28; C07D335/02; C07D405/10; C07D405/12; C07D407/12; C07D409/10; C07D413/12; C07D417/12; C07D417/14; C07D491/08; C07D521/00; (IPC1-7): C07D417/12; C07D405/12; C07D413/12; C07D277/46; C07D417/14; C07D491/08; A61K31/427; A61K31/4439; A61K31/454; A61K31/495; A61P3/10; C07D309/04; C07D277/40
Domestic Patent References:
| WO2001012189A1 | 2001-02-22 | |||
| WO2002008209A1 | 2002-01-31 | |||
| WO2003095438A1 | 2003-11-20 | |||
| WO2004063179A1 | 2004-07-29 |
Foreign References:
| US6320050B1 | 2001-11-20 | |||
| US4046768A | 1977-09-06 |
Other References:
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002284124, retrieved from STN Database accession no. 1964:4864
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002284125, retrieved from STN Database accession no. 1958:25545
CHEMICAL ABSTRACTS, vol. 55, no. 8, 17 April 1961, Columbus, Ohio, US; SAIKACHI H ET AL: "Syntheses of furan derivatives. XXVII. 2-Phenyl-3-(5-nitro-2-furyl)acrylic acid, 2-phenyl-5-(5-nitro-2-furyl)-2,4- pentadienoic acid, an their amides" column 7380; XP002284123
KASCHERES A ET AL: "Reaction of diphenylcyclopropenone with 2-aminopyridines. Synthetic and mechanistic implications", JOURNAL OF ORGANIC CHEMISTRY, vol. 40, no. 10, 16 May 1975 (1975-05-16), pages 1440 - 1444, XP002284121
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002284126, retrieved from STN Database accession no. 2002:273644
KASCHERES A ET AL: "Reaction of diphenylcyclopropenone with 2-aminothiazoles and related compounds", HETEROCYCLES, vol. 22, no. 11, 1984, pages 2529 - 2540, XP008031620
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002284125, retrieved from STN Database accession no. 1958:25545
CHEMICAL ABSTRACTS, vol. 55, no. 8, 17 April 1961, Columbus, Ohio, US; SAIKACHI H ET AL: "Syntheses of furan derivatives. XXVII. 2-Phenyl-3-(5-nitro-2-furyl)acrylic acid, 2-phenyl-5-(5-nitro-2-furyl)-2,4- pentadienoic acid, an their amides" column 7380; XP002284123
KASCHERES A ET AL: "Reaction of diphenylcyclopropenone with 2-aminopyridines. Synthetic and mechanistic implications", JOURNAL OF ORGANIC CHEMISTRY, vol. 40, no. 10, 16 May 1975 (1975-05-16), pages 1440 - 1444, XP002284121
DATABASE CHEMCATS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002284126, retrieved from STN Database accession no. 2002:273644
KASCHERES A ET AL: "Reaction of diphenylcyclopropenone with 2-aminothiazoles and related compounds", HETEROCYCLES, vol. 22, no. 11, 1984, pages 2529 - 2540, XP008031620
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