Title:
PHENYLACRYLIC ACID ESTHER COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/127747
Kind Code:
A1
Abstract:
Disclosed are a phenyl acrylic acid esther compound, and a pharmaceutically acceptable salt, solvate and prodrug thereof, a tautomer or a stereochemical isomer or a pharmaceutical composition, and uses of the pharmaceutical composition acting as an antithrombotic, anti-inflammatory, and anti-stroke drug.
Inventors:
LIU QIAN (CN)
LI YUNSEN (CN)
DENG SHIPING (CN)
GAO YUAN (CN)
LOU SHANNING (CN)
YU YUNHUI (CN)
JIANG CHUANLIANG (CN)
LI YUNSEN (CN)
DENG SHIPING (CN)
GAO YUAN (CN)
LOU SHANNING (CN)
YU YUNHUI (CN)
JIANG CHUANLIANG (CN)
Application Number:
PCT/CN2018/073358
Publication Date:
July 04, 2019
Filing Date:
January 19, 2018
Export Citation:
Assignee:
SUZHOU PHARMAVAN CANCER RES CENTER CO LTD (CN)
International Classes:
C07C69/612; A61P7/02; A61P29/00; C07C35/30; C07C47/575; C07C57/44; C07C69/38
Foreign References:
| CN103070861A | 2013-05-01 |
Other References:
MALDONADO EMMA: "Anti-Inflammatory Activity of Phenyl Propanoids from Coreopsis mutica var. mutica", PLANTA MEDICA, vol. 64, no. 7, 31 December 1998 (1998-12-31), pages 660 - 661, ISSN: 0032-0943
GLASER JAN: "Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni", MOLECULES, vol. 20, no. 6, 12 June 2015 (2015-06-12), pages 10873 - 83, XP055624131, ISSN: 1420-3049
GLASER JAN: "Antileishmanial and Cytotoxic Compounds from Valeriana wa- llichii and Identification of a Novel Nepetolactone Derivative", MOLECULES, vol. 20, no. 4, 1 April 2015 (2015-04-01), pages 5740 - 5753, XP055624135, ISSN: 1420-3049
XIA CHUN-NIAN: "Synthesis of Trans-caffeate Analogues and Their Bioactivities against HIV-1 Integrase and Cancer Cell Lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 15 October 2008 (2008-10-15), pages 6553 - 6557, XP025679073, ISSN: 0960-894X
CHEN HUI-ZHEN: "Synthesis and Antitumor Activity of Feruloyl and Caffeoyl Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18 August 2014 (2014-08-18), XP029053349, ISSN: 0960-894X
GLASER JAN: "Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni", MOLECULES, vol. 20, no. 6, 12 June 2015 (2015-06-12), pages 10873 - 83, XP055624131, ISSN: 1420-3049
GLASER JAN: "Antileishmanial and Cytotoxic Compounds from Valeriana wa- llichii and Identification of a Novel Nepetolactone Derivative", MOLECULES, vol. 20, no. 4, 1 April 2015 (2015-04-01), pages 5740 - 5753, XP055624135, ISSN: 1420-3049
XIA CHUN-NIAN: "Synthesis of Trans-caffeate Analogues and Their Bioactivities against HIV-1 Integrase and Cancer Cell Lines", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 24, 15 October 2008 (2008-10-15), pages 6553 - 6557, XP025679073, ISSN: 0960-894X
CHEN HUI-ZHEN: "Synthesis and Antitumor Activity of Feruloyl and Caffeoyl Derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18 August 2014 (2014-08-18), XP029053349, ISSN: 0960-894X
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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