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Title:
PHENYLALANINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/068415
Kind Code:
A1
Abstract:
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 carbon atoms or the like; Z represents a phenyl group or the like; R2 represents a hydrogen atom or a lower alkyl group; n represents a number such as 0; and when n is 0, Y represents NOR3 (wherein R3 represents a methyl group or the like), CCl2 or the like.)

Inventors:
UDA JUNICHIRO (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
Application Number:
PCT/JP2005/000666
Publication Date:
July 28, 2005
Filing Date:
January 20, 2005
Export Citation:
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Assignee:
FUJIYAKUHIN CO LTD (JP)
UDA JUNICHIRO (JP)
OKAMOTO YASUSHI (JP)
IWABUCHI TAKEYUKI (JP)
INOUE TSUTOMU (JP)
NAKANO HIROYUKI (JP)
ISHIKAWA TOMOHIKO (JP)
KAWASAKI NOBUHIDE (JP)
KATOH MASUMI (JP)
International Classes:
C07C233/31; C07C233/49; C07C233/50; C07C233/51; C07C251/38; C07C251/40; C07C251/42; C07C251/44; C07C251/48; C07C317/44; C07C323/59; C07C323/63; C07D209/20; C07D211/34; C07D213/56; C07D295/205; C07D307/54; C07D309/06; C07D317/60; C07D333/24; C07D335/02; C07D339/08; C07D409/12; (IPC1-7): C07C233/49; C07C233/51; C07C251/34; C07C317/50; C07C323/59; C07C323/63; C07D209/04; C07D211/06; C07D213/53; C07D295/20; C07D309/06; C07D317/58; C07D333/22; C07D335/02; C07D339/08; C07D405/12; C07D409/12; C07D417/04; A61K31/198; A61K31/341; A61K31/36; A61K31/351; A61K31/381; A61K31/382; A61K31/385; A61K31/4409; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/5375; A61P29/00; A61P43/00
Foreign References:
Other References:
CHEN L. ET AL: "N-Acyl phenylalanine analogues as potent small molecule VLA-4 antagonists", BIOORGANIC & MEDICAL CHEMISTRY, vol. 10, no. 8, April 2000 (2000-04-01), pages 725 - 727
Attorney, Agent or Firm:
The, Patent Corporate Body Aruga Patent Office (3-6 NIHONBASHININGYOCHO 1-CHOME CHUO-KU, Tokyo 13, JP)
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