PHENYLALKANOIC ACID DERIVATIVE, PRODUCTION THEREOF, AND SEPARATION OF OPTICAL ISOMERS THEREOF

Title:

PHENYLALKANOIC ACID DERIVATIVE, PRODUCTION THEREOF, AND SEPARATION OF OPTICAL ISOMERS THEREOF

Document Type and Number:

WIPO Patent Application WO/1993/002999

Kind Code:

A1

Abstract:

A novel phenylalkanoic acid derivative represented by general formulae (I) or (II), a process for the production thereof, a method of separating optical isomers thereof, and an anti-inflammatory, analgesic or external preparation containing the same. In the said formulae, n represents an integer of 1 or 2; X represents halogen, alkoxy or nitro; R represents hydrogen or alkyl; and Z represents hydrogen or acyl.

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Inventors:

SAITA MASARU (JP)
INOUE HISATAKA (JP)
BEPPU KOICHI (JP)
HACHIYA TERUMI (JP)
SHINOHARA IKUO (JP)
TANIGUCHI YASUAKI (JP)

Application Number:

PCT/JP1992/000995

Publication Date:

February 18, 1993

Filing Date:

August 04, 1992

Export Citation:

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Assignee:

HISAMITSU PHARMACEUTICAL CO (JP)

International Classes:

A61K31/19; A61K31/215; C07C45/56; C07C45/63; C07C49/697; C07C49/747; C07C59/54; C07C59/56; C07C59/72; C07C59/86; C07C59/88; C07C59/90; C07C69/013; C07C69/73; C07C69/732; C07C69/738; C07C205/56; (IPC1-7): A61K31/19; A61K31/215; C07C59/54; C07C59/72; C07C59/86; C07C69/013; C07C69/73; C07C205/56

Foreign References:

JPS54103852A	1979-08-15
JPS59196839A	1984-11-08
JPS574919A	1982-01-11
JPS53135958A	1978-11-28

Other References:

Chemical & Pharmaceutical Bulletin, Vol. 31, No. 12, December 1983, Tokyo, Japan, S. NARUTO et al, "Optical Resolution and Determination of Absolute Configuration of (+)-2-[4-(2-Oxocyclopentylmethyl)phenyl]pro pionic Acids", p. 4286-94
Chemical & Pharmaceutical Bulletin, Vol. 31, No. 12, December 1983, Tokyo, Japan, S. NARUTO et al, "Synthesis of Eight Possible Optically Active Isomers of 2-[4-(2-Hydroxycyclopentylmethyl)phenyl]pro pionic Acid", p. 4319-23
Journal of Medicinal Chemistry, Vol. 27, No. 2, February 1984, Columbus, USA, A. TERADA et al, "Synthesis and Antiinflammatory Activity of [(Cycloalkylmethyl phenyl]acetic Acids and Related Compounds", p. 212-5

Attorney, Agent or Firm:

Itoh, Tatsuo (8-1 Toranomon 2-chom, Minato-ku Tokyo 105, JP)

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