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Title:
PHENYLATE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/202276
Kind Code:
A1
Abstract:
A phenylate derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a phenylate derivative represented by formula I, a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, and a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.

Inventors:
FENG, Zhiqiang (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
CHEN, Xiaoguang (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
YANG, Yang (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
ZHOU, Chuan (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
LAI, Fangfang (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
JI, Ming (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
JIN, Xiaofeng (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
XUE, Nina (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
ZHENG, Yi (No.A2, Nan Wei Road Xicheng District, Beijing 0, 100050, CN)
CHEN, Hao (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
LI, Ling (No.A2, Nan Wei RoadXicheng District, Beijing 0, 100050, CN)
Application Number:
CN2017/085420
Publication Date:
November 30, 2017
Filing Date:
May 23, 2017
Export Citation:
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Assignee:
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (ZHANG Xubin, No.A2 Nan Wei Road, Xicheng District, Beijing 0, 100050, CN)
International Classes:
C07C43/174; A61K31/03; A61K31/075; A61K31/357; A61P35/00; C07C43/235; C07D319/16
Domestic Patent References:
WO2007106469A22007-09-20
Foreign References:
CN1735408A2006-02-15
Other References:
SASAKI, S. ET AL.: "Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 5, 14 February 2011 (2011-02-14), pages 1365 - 1378, XP055168132
YAO, S. H. ET AL.: "An efficient multistep ligand-based virtual screening approach for GPR40 agonists", MOLECULAR DIVERS, vol. 18, no. 1, 5 December 2013 (2013-12-05), pages 183 - 193, XP055441272
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