Title:
PHENYLATED 3-DEAZAURIDINE ANALOGUES AT THE C3 POSITION AS ANTIVIRAL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2011/070152
Kind Code:
A3
Abstract:
The present invention relates to novel antiviral compounds, which are aryl 3-deazauridine analogues at the C3 position, to a method for synthesizing said compounds, as well as to the antiviral uses thereof. The compounds are of the general formula (I), where: R1 is a hydrogen atom or a C2-C6 acyl, R2, R3, R4, R5 and R6 are independently selected from a hydrogen atom, a C1-C6 alkyl, a C1-C6 alkoxy, a halogen atom, a nitro grouping or a cyano grouping, provided that at least one of R2, R3, R4, R5 and R6 is not the hydrogen atom. The invention also relates to the pharmaceutically acceptable salts thereof, to the enantiomers or diastereomers thereof, or to the mixtures thereof.
Inventors:
FELPIN FRANCOIS XAVIER (FR)
BOURGOUGNON NATHALIE (FR)
ZANESE MARION (FR)
BOURGOUGNON NATHALIE (FR)
ZANESE MARION (FR)
Application Number:
PCT/EP2010/069375
Publication Date:
March 15, 2012
Filing Date:
December 10, 2010
Export Citation:
Assignee:
UNIV BORDEAUX 1 (FR)
UNIV BRETAGNE SUD (FR)
FELPIN FRANCOIS XAVIER (FR)
BOURGOUGNON NATHALIE (FR)
ZANESE MARION (FR)
UNIV BRETAGNE SUD (FR)
FELPIN FRANCOIS XAVIER (FR)
BOURGOUGNON NATHALIE (FR)
ZANESE MARION (FR)
International Classes:
C07H19/04; A61K31/706
Foreign References:
| US3836645A | 1974-09-17 |
Other References:
MCNAMARA D J ET AL: "Synthesis, antitumor activity, and antiviral activity of 3-substituted 3-deazacytidines and 3-substituted 3-deazauridines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US LNKD- DOI:10.1021/JM00169A032, vol. 33, no. 7, 1 July 1990 (1990-07-01), pages 2006 - 2011, XP002548340, ISSN: 0022-2623
LEGRAVEREND M ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 3 DEAZACYTIDINE AND 3 DEAZAURIDINE DERIVATIVES", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 5, no. 2, 1 January 1986 (1986-01-01), pages 125 - 134, XP009140114, ISSN: 0732-8311
LEGRAVEREND M ET AL: "SYNTHESIS AND BIOLOGICAL EVALUATION OF 3 DEAZACYTIDINE AND 3 DEAZAURIDINE DERIVATIVES", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, vol. 5, no. 2, 1 January 1986 (1986-01-01), pages 125 - 134, XP009140114, ISSN: 0732-8311
Attorney, Agent or Firm:
WARCOIN, Jacques (20 rue de Chazelles, Paris Cedex 17, FR)
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