Title:
PHENYLENE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/026962
Kind Code:
A1
Abstract:
It is intended to provide a novel phenylene derivative represented by the following
general formula (I), which is useful as a remedy or a preventive for renal disorders
(nephritis, nephropathy, nephrosclerosis, renal failure and so on), diabetic
complications (nephropathy, neuropathy, retinopathy, cataract, microangiopathy,
skin damage and so on), cardiovascular diseases (myocardial infarction, heart
enlargement, heart failure, arteriosclerosis, coronary diseases, peripheral
circulatory disturbance, cerebrovascular disorder, hypertension, systolic
hypertension, restenosis after angiogenesis and so on), cerebral metabolic
impairment (Alzheimer’s disease, Parkinson’s disease and
so on), dialysis-related amyloidosis that is a complication of dialysis, peritoneal
sclerosis observed in a patient under peritoneal dialysis, rheumatoid arthritis,
solar elastosis, aging, senile cataract and so on: (I) wherein A is a group represented
by the following general formula (A1), (A2), (A3) or (A4): (A1) (A2) (A3) (A4)
and other symbols have each the same meaning as defined in the description; and
a pharmacologically acceptable salt and ester thereof.
Inventors:
KUROKAWA KIYOSHI (JP)
MIYATA TOSHIO (JP)
YANAGISAWA HIROAKI (JP)
MIYATA TOSHIO (JP)
YANAGISAWA HIROAKI (JP)
Application Number:
PCT/JP2006/317708
Publication Date:
March 08, 2007
Filing Date:
August 31, 2006
Export Citation:
Assignee:
SANKYO CO (JP)
UNIV TOKAI EDUCATIONAL SYSTEM (JP)
KUROKAWA KIYOSHI (JP)
MIYATA TOSHIO (JP)
YANAGISAWA HIROAKI (JP)
UNIV TOKAI EDUCATIONAL SYSTEM (JP)
KUROKAWA KIYOSHI (JP)
MIYATA TOSHIO (JP)
YANAGISAWA HIROAKI (JP)
International Classes:
C07D257/04; A61K31/41; A61K31/4178; A61K31/422; A61K31/426; A61K31/427; A61K31/4439; A61K31/4709; A61K31/473; A61K31/55; A61P3/10; A61P7/08; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P13/12; A61P17/16; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P27/12; A61P29/00; A61P43/00; C07D277/20; C07D277/34; C07D401/12; C07D403/10; C07D413/12; C07D413/14; C07D417/10; C07D417/12; C07D417/14
Domestic Patent References:
| WO2005030737A1 | 2005-04-07 | |||
| WO2002083127A1 | 2002-10-24 |
Foreign References:
| JP2002255813A | 2002-09-11 | |||
| JPH10310524A | 1998-11-24 | |||
| JP2004300153A | 2004-10-28 |
Other References:
WAHHAB A. ET AL.: "Imidazole Based Non-Peptide Angiotensin II Receptor Antagonists", ARZNEIMITTEL FORSCHUNG DRUG RESEARCH, vol. 43, no. 11, 1993, pages 1157 - 1168, XP001207208
KIM M.Y. ET AL.: "Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Oxoquinoline Derivatives, New Nonpeptide Angiotensin II receptor Antagonists", KOREAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 5, no. 1, 1995, pages 28 - 37, XP002983626
KIM M.Y. ET AL.: "Synthesis, Biological Properties, and Structure-Activity Relationships of 2-Oxoquinoline Derivatives, New Nonpeptide Angiotensin II receptor Antagonists", KOREAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 5, no. 1, 1995, pages 28 - 37, XP002983626
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
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