Title:
PHENYLIMIDAZOLE DERIVATIVE, AND THERAPEUTIC MEDICINE OR PREVENTIVE MEDICINE FOR INFLAMMATORY DISEASE, ETC.
Document Type and Number:
WIPO Patent Application WO/2015/002061
Kind Code:
A1
Abstract:
Provided is a medicinal active ingredient which is useful for treating or preventing inflammatory diseases, diseases caused by lipid oxidation, retinochoroidal disorders, etc. The present invention is a phenylimidazole derivative represented by formula (IB) or a salt thereof. The present invention is also therapeutic medicine or preventive medicine for inflammatory diseases, diseases caused by lipid oxidation, retinochoroidal disorders, etc., the medicine comprising at least one type selected from the phenylimidazole derivative, a salt thereof and metabolites thereof as an active ingredient. In formula (IB), R1a is an alkyl group, etc., R2 is an amino group, etc., R3 is a halogen atom, alkyl group, etc., R4 is a cyano group, etc., R5 is an alkyl group, etc., and R6 is an alkyl group, etc.
Formula (IB)
Inventors:
UMEDA NOBUHIRO (JP)
TSUBOKURA SHIRO (JP)
UCHIDA SEIICHI (JP)
KOIZUMI KEIJI (JP)
MOROE HIROKO (JP)
OHSHIO ICHIRO (JP)
TSUBOKURA SHIRO (JP)
UCHIDA SEIICHI (JP)
KOIZUMI KEIJI (JP)
MOROE HIROKO (JP)
OHSHIO ICHIRO (JP)
Application Number:
PCT/JP2014/067003
Publication Date:
January 08, 2015
Filing Date:
June 26, 2014
Export Citation:
Assignee:
NIPPON SODA CO (JP)
International Classes:
A61K31/4178; C07D233/61; A61K31/454; A61K31/496; A61K31/5377; A61P27/02; A61P29/00; A61P39/06; C07D403/10; C07D471/08
Domestic Patent References:
| WO2011016559A1 | 2011-02-10 | |||
| WO2005012293A1 | 2005-02-10 | |||
| WO2009133701A1 | 2009-11-05 | |||
| WO2011149010A1 | 2011-12-01 | |||
| WO2011149012A1 | 2011-12-01 | |||
| WO2007052794A1 | 2007-05-10 | |||
| WO2009133701A1 | 2009-11-05 |
Foreign References:
| JP2003517479A | 2003-05-27 | |||
| JP2003012666A | 2003-01-15 | |||
| JP2003503489A | 2003-01-28 | |||
| JPH04164032A | 1992-06-09 | |||
| JPH023678A | 1990-01-09 |
Other References:
ANGELL, RICHARD M. ET AL.: "Biphenyl amide p38 kinase inhibitors. 2: Optimization and SAR", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 324 - 328, XP022410909
NIH PUBLIC ACCESS, vol. 71, 2012, pages 56 - 67
THE JAPANESE PHARMACOLOGICAL SOCIETY, vol. 124, 2004, pages 415 - 425
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING COMPANY
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, 2002, pages 1162 - 1167
OPTHALMOLOGY CLINIC PRACTICE, vol. 5, 2002, pages 93
JOURNAL OF NEUROSCIENCE RESEARCH, vol. 86, 2008, pages 904 - 909
PROGRESS IN LIPID RESEARCH, vol. 45, 2006, pages 334 - 356
AGENTS ACTIONS, vol. 17, 1986, pages 366 - 367
BIOCHEMICAL PHARMACOLOGY, vol. 34, 1985, pages 2695 - 2704
See also references of EP 2998298A4
NIH PUBLIC ACCESS, vol. 71, 2012, pages 56 - 67
THE JAPANESE PHARMACOLOGICAL SOCIETY, vol. 124, 2004, pages 415 - 425
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING COMPANY
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 43, 2002, pages 1162 - 1167
OPTHALMOLOGY CLINIC PRACTICE, vol. 5, 2002, pages 93
JOURNAL OF NEUROSCIENCE RESEARCH, vol. 86, 2008, pages 904 - 909
PROGRESS IN LIPID RESEARCH, vol. 45, 2006, pages 334 - 356
AGENTS ACTIONS, vol. 17, 1986, pages 366 - 367
BIOCHEMICAL PHARMACOLOGY, vol. 34, 1985, pages 2695 - 2704
See also references of EP 2998298A4
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
Masatake Shiga (JP)
Masatake Shiga (JP)
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