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Title:
PHENYLPROPANOID AND PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/157260
Kind Code:
A1
Abstract:
Provided are a phenylpropanoid and a preparation method and application thereof. The phenylpropanoid has a structure represented by formula (I), and a pharmaceutically acceptable salt thereof has a structure represented by formula (II) or formula (III). The phenylpropanoid and the pharmaceutically acceptable salt thereof are capable of suppressing the amount of the inflammatory cytokine NO and the expression of the inflammatory cytokine TNF-α and inhibiting the hydroxy free radical -OH, and hence have anti-inflammatory and anti-oxidant activities. Thus, the phenylpropanoid and the pharmaceutical acceptable salt thereof have a good prospect of application in the preparation of a medicament for treating diseases associated with the above factors, including inflammatory diseases such as cervicitis, endometritis, pelvic inflammatory disease, mastitis, esophagitis and arthritis.

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Inventors:
ZHANG PENG (CN)
PENG KAIFENG (CN)
GONG YUN (CN)
LI FUJUN (CN)
LIU NIFU (CN)
XIA BOHOU (CN)
LIN LIMEI (CN)
Application Number:
PCT/CN2017/076455
Publication Date:
September 21, 2017
Filing Date:
March 13, 2017
Export Citation:
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Assignee:
QIANJIN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H15/203; A61K31/7034; A61K36/19; A61K36/29; A61K36/486; A61K36/738; A61K36/758; A61P15/00; A61P19/02; A61P29/00
Domestic Patent References:
WO2003101446A12003-12-11
Foreign References:
CN105777821A2016-07-20
CN105732736A2016-07-06
CN105708845A2016-06-29
CN101058594A2007-10-24
CN101235059A2008-08-06
CN101538272A2009-09-23
Other References:
WANG, KAIJIN ET AL.: "Antioxidant phenolic constituents from Fagopyrum dibotrys", JOURNAL OF ETHNOPHARMACOLOGY, vol. 99, no. 2, 7 April 2005 (2005-04-07), pages 259 - 264, XP027757513
KUO, Y.H. ET AL.: "Cytotoxic Phenylpropanoid Glycosides from the Stems of Smilax china", J. NAT. PROD., vol. 68, no. 10, 6 October 2005 (2005-10-06), pages 1475 - 1478, XP055420104
Attorney, Agent or Firm:
YOGO PATENT & TRADE MARK AGENCY LIMITED COMPANY (CN)
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