Title:
PHENYLTHIOPHENE SULFONAMIDE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/012689
Kind Code:
A1
Abstract:
Disclosed herein are phenylthiophene sulfonamide compounds, pharmaceutical compositions, a preparation method therefor and use thereof. The compounds of the present invention are capable of effectively and selectively inhibiting Bcl-xL, Bcl-2 or Mcl-1, particularly Mcl-1, in the critical protein Bcl-2 family during apoptosis at the molecular level. At the same time, they have obvious killing effect and high selectivity against cancer cells, especially human cervical cancer cell HeLa, human acute lymphocytic leukemia cell line RS4; 11 or human promyelocytic leukemia cell line HL-60, have the potential to be prepared as a new anti-tumor medicament, and have a good market prospect.
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Inventors:
WANG RENXIAO (CN)
HONG RAN (CN)
FAN WENJIE (CN)
TIAN JIE (CN)
LI YAN (CN)
ZHOU MI (CN)
LI QING (CN)
KONG WENNA (CN)
LI YANGFENG (CN)
LI JIE (CN)
HONG RAN (CN)
FAN WENJIE (CN)
TIAN JIE (CN)
LI YAN (CN)
ZHOU MI (CN)
LI QING (CN)
KONG WENNA (CN)
LI YANGFENG (CN)
LI JIE (CN)
Application Number:
PCT/CN2020/079854
Publication Date:
January 28, 2021
Filing Date:
March 18, 2020
Export Citation:
Assignee:
SHANGHAI INSITITUTE OF ORGANIC CHEMISTRY CHINESE ACAD OF SCIENCES (CN)
International Classes:
C07D333/34; A61K31/381; A61P35/00; A61P35/02; C07C43/29; C07C43/295; C07C205/38; C07C217/90; C07F7/18
Foreign References:
| CN110330477A | 2019-10-15 | |||
| CN109384764A | 2019-02-26 | |||
| CN103450149A | 2013-12-18 | |||
| CN103373969A | 2013-10-30 |
Other References:
YANG CHENGWEN ET AL.: "Development of 3-Phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide Compounds as Inhibitors of Antiapoptotic Bcl-2 Family Proteins", CHEMMEDCHEM, vol. 9, no. 7, 29 April 2014 (2014-04-29), pages 1436 - 1452, XP055774640, ISSN: 1860-7187
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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