Title:
PHILLYGENIN GLUCURONIC ACID DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/161951
Kind Code:
A1
Abstract:
A phillygenin glucuronic acid derivative represented by general formula (I). In general formula (I), R1=H, R2=CnH2n+1, and R3=CnH2n+1; or R1=CnH2n+1, R2=CnH2n+1, and R3=H; or R1-R2=-CH2-, and R3=CnH2n+1; n=1 to 30. The present invention also relates to a preparation method for the compound, a pharmaceutical composition having the compound as an active component, and an application of the compound in antiviral symptoms.
Inventors:
FU LI (CN)
FAN HONGYU (CN)
JIANG RENWU (CN)
ZHANG YU (CN)
WANG KAIQIAN (CN)
LIU ZHENGXIAN (CN)
FAN HONGYU (CN)
JIANG RENWU (CN)
ZHANG YU (CN)
WANG KAIQIAN (CN)
LIU ZHENGXIAN (CN)
Application Number:
PCT/CN2016/078688
Publication Date:
October 13, 2016
Filing Date:
April 07, 2016
Export Citation:
Assignee:
FU LI (CN)
International Classes:
C07H15/26; A61K31/7048; A61P29/00; A61P31/16; C07H1/08
Foreign References:
| CN104945452A | 2015-09-30 |
Other References:
SOLER, A. ET AL.: "Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line", FOOD CHEMISTRY, vol. 119, no. 2, 31 December 2010 (2010-12-31), pages 703 - 714, XP026709162
DUAN, LINJIAN ET AL.: "Effect of Phillyrin on Gene Expression of Influenza A Virus Nucleoprotein", CHINESE GENERAL PRACTICE, vol. 15, no. 6C, 30 June 2012 (2012-06-30), pages 2082 - 2084, XP009506755
FAN, HONGYU ET AL.: "Synthesis and Structure Characterization of Phillyrin", LIAONING CHEMICAL INDUSTRY, vol. 43, no. 3, 31 March 2014 (2014-03-31), pages 241 - 243, XP008184136
See also references of EP 3281945A4
DUAN, LINJIAN ET AL.: "Effect of Phillyrin on Gene Expression of Influenza A Virus Nucleoprotein", CHINESE GENERAL PRACTICE, vol. 15, no. 6C, 30 June 2012 (2012-06-30), pages 2082 - 2084, XP009506755
FAN, HONGYU ET AL.: "Synthesis and Structure Characterization of Phillyrin", LIAONING CHEMICAL INDUSTRY, vol. 43, no. 3, 31 March 2014 (2014-03-31), pages 241 - 243, XP008184136
See also references of EP 3281945A4
Attorney, Agent or Firm:
BEIJING YUANBEN INTELLECTUAL PROPERTY LAW OFFICE (CN)
北京元本知识产权代理事务所 (CN)
北京元本知识产权代理事务所 (CN)
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