Title:
PHOSPHATE BINDING MATERIALS AND THEIR USES
Document Type and Number:
WIPO Patent Application WO/2010/015827
Kind Code:
A3
Abstract:
Phosphate binding materials and compositions comprising them which are solid ligand-modif ied poly oxo-hydroxy metal ion materials are disclosed that are based on ferric iron oxo- hydroxides modified with carboxylic acid ligands, or ionised forms thereof. These materials are made and tested in the examples provided in the application to demonstrate that they can bind phosphate in "in vitro" an in "in vivo" studies. They are useful for treating hyperphosphatenia or for removing phosphate from a medium.
Inventors:
POWELL JONATHAN JOSEPH (GB)
FARIA NUNO JORGE RODRIGUES (GB)
FARIA NUNO JORGE RODRIGUES (GB)
Application Number:
PCT/GB2009/001931
Publication Date:
April 01, 2010
Filing Date:
August 05, 2009
Export Citation:
Assignee:
MEDICAL RES COUNCIL (GB)
POWELL JONATHAN JOSEPH (GB)
FARIA NUNO JORGE RODRIGUES (GB)
POWELL JONATHAN JOSEPH (GB)
FARIA NUNO JORGE RODRIGUES (GB)
International Classes:
A61K31/26; A23L5/20; A23L29/294; A61K31/295; A61K31/80; A61K45/06; A61P39/04; C07F15/02
Domestic Patent References:
| WO2008071747A1 | 2008-06-19 | |||
| WO2004074444A2 | 2004-09-02 | |||
| WO2008096130A1 | 2008-08-14 |
Foreign References:
| US6174442B1 | 2001-01-16 | |||
| GB1226394A | 1971-03-24 |
Other References:
"Humic acid", XP002567060, Retrieved from the Internet [retrieved on 20100205]
SPENGLER K ET AL: "Characterization and extracorporeal application of a new phosphate-binding agent", EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, vol. 32, no. 10, 1994, pages 733 - 739, XP008002870
SPENGLER K ET AL: "Cross-linked iron dextran is an efficient oral phosphate binder in the rat", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 11, no. 5, 1996, pages 808 - 812, XP008002872, ISSN: 0931-0509
SPENGLER K ET AL: "Characterization and extracorporeal application of a new phosphate-binding agent", EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, vol. 32, no. 10, 1994, pages 733 - 739, XP008002870
SPENGLER K ET AL: "Cross-linked iron dextran is an efficient oral phosphate binder in the rat", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 11, no. 5, 1996, pages 808 - 812, XP008002872, ISSN: 0931-0509
Attorney, Agent or Firm:
KIDDLE, Simon et al. (33 Gutter Lane, London EC2V 8AS, GB)
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