Title:
PHOSPHINE TRANSITION METAL COMPLEX, PROCESS FOR PRODUCING THE SAME AND ANTICANCER DRUG CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2006/112435
Kind Code:
A1
Abstract:
Novel phosphine transition metal complexes having an excellent anticancer potency, represented by the general formula: (1) wherein each of R1 and R3 is an alkyl, a cycloalkyl, an aryl, an aralkyl, pyridyl or pyrimidyl; each of R2 and R4 is an alkyl or a cycloalkyl, provided that R1 and R2, also R3 and R4, are not identical groups; A is a linear alkylene or cisvinylene; M is a gold, silver, cupper or platinum atom; and B is an anion species.
Inventors:
KODAMA HIROAKI (JP)
OHTO KEISUKE (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
KANEDA YOSHIROU (JP)
OHTO KEISUKE (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
KANEDA YOSHIROU (JP)
Application Number:
PCT/JP2006/308035
Publication Date:
October 26, 2006
Filing Date:
April 17, 2006
Export Citation:
Assignee:
NIPPON CHEMICAL IND (JP)
KODAMA HIROAKI (JP)
OHTO KEISUKE (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
KANEDA YOSHIROU (JP)
KODAMA HIROAKI (JP)
OHTO KEISUKE (JP)
OOHARA NOBUHIKO (JP)
NAKATSUI KAZUHIRO (JP)
KANEDA YOSHIROU (JP)
International Classes:
C07F9/50; A61K31/66; A61P35/00; C07F9/58; C07F1/08; C07F1/10; C07F1/12; C07F15/00
Foreign References:
JPH10509957A | 1998-09-29 | |||
JPS62161795A | 1987-07-17 | |||
JPS6110594A | 1986-01-18 | |||
JPH10509957A | 1998-09-29 | |||
JPS6110594A | 1986-01-18 | |||
EP0164970A2 | 1985-12-18 |
Other References:
See also references of EP 1876182A4
Attorney, Agent or Firm:
NIPPON CHEMICAL INDUSTRIAL CO., LTD (Kameido Koto-ku, Tokyo15, JP)
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