PHOSPHODIESTERASE INHIBITOR TYPE 5 (PDE 5), AND PREPARATION METHOD AND APPLICATION THEREOF

Title:

PHOSPHODIESTERASE INHIBITOR TYPE 5 (PDE 5), AND PREPARATION METHOD AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/000504

Kind Code:

A1

Abstract:

Provided are a PDE 5 and a preparation method therefor, and application of the PDE 5 to preparation of drugs used for treating, alleviating or preventing PDE 5-related diseases or disease states of mammals. The structural formula of the compound is I or II. The preparation method for the compound is simple in process and mild in reaction conditions and utilizes cheap and easily available raw materials; the prepared PDE 5 has the advantages of a definite target, high security and outstanding active effect and shows good application prospects in preparation of drugs used for treating PDE 5-related diseases, especially Male Erectile Dysfunction (MED) or Pulmonary Hypertension (PAH).

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Inventors:

LOU HONGXIANG (CN)
ZHENG HONGBO (CN)
SUN BIN (CN)
LI LIN (CN)
GAO YUN (CN)

Application Number:

PCT/CN2017/093149

Publication Date:

January 03, 2019

Filing Date:

July 17, 2017

Export Citation:

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Assignee:

UNIV SHANDONG (CN)

International Classes:

C07D471/04; A61K31/444; A61K31/506; A61P9/12; A61P15/10

Foreign References:

CN1446217A	2003-10-01
CN1441801A	2003-09-10

Other References:

JIANG, WEIQIN ET AL.: "Furoyl and Benzofuroyl Pyrroloquinolones as Potent and Selective PDE 5 Inhibitors for Treatment of Erectile Dysfunction", J. MED. CHEM., vol. 46, no. 3, 30 January 2003 (2003-01-30), pages 441 - 444, XP002327015
JIANG, WEIQIN ET AL.: "Pyrroloquinolone PDE 5 Inhibitors with Improved Pharmaceutical Profiles for Clinical Studies on Erectile Dysfunction", J. MED. CHEM., vol. 48, no. 6, 1 March 2005 (2005-03-01), pages 2126 - 2133, XP055558701

Attorney, Agent or Firm:

JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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