Title:
PHOSPHONATED AGENTS AND THEIR ANTIANGIOGENIC AND ANTITUMORIGENIC USE
Document Type and Number:
WIPO Patent Application WO1999005148
Kind Code:
A8
Abstract:
Novel phosphonic acid agents are synthesized and characterized and their pharmaceutical compositions provided. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown. Embodiments of the phosphonic acid agents include: (P-Yn1)m1-Q<1>-K-(Q<2>-(Yn2-P)m2)j wherein P is a phosphonic group or a phosphonic salt, Y is -OCO-, -NR<1>CO- or CON(R<1>)R<2>-; R<1> is H, CH2CO2H, or substituted or unsubstituted alkyl; R<2> is substituted alkyl, aryl or arylalkyl; Q<1> and Q<2> are substituted or unsubstituted aryl groups; K is H, -NH-CO-NH-, -NH-CS-NH-, -NHCO-R<3>-CONH- or -NHCS-R<3>-CSNH-; provided when K is H, R<3> is a substituted or unsubstituted aryl group; j is 0; j is 0,1,2; n1 and n2 are independently 0,1 or 2; and m1 and m2 are independently an integer from 1-4.
Inventors:
COLLINS DELWOOD C
GAGLIARDI ANTONIO R
NICKEL PETER
GAGLIARDI ANTONIO R
NICKEL PETER
Application Number:
PCT/US1998/015470
Publication Date:
May 14, 1999
Filing Date:
July 24, 1998
Export Citation:
Assignee:
UNIV KENTUCKY RES FOUND (US)
International Classes:
C07F9/38; (IPC1-7): C07F9/22; C07F9/38; C07F9/44
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