Title:
PHOSPHONIC ACID DERIVATIVE HAVING CD73 INHIBITORY ACTIVITY, AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/129059
Kind Code:
A1
Abstract:
The present invention relates to a phosphonic acid derivative having a CD73 inhibitory activity and a structure of formula (I), and a preparation method and use thereof. The series of compounds of the present invention can be widely used in preparing drugs for treating cancers or tumors, autoimmune diseases and disorders and metabolic diseases at least partially mediated by CD73, in particular drugs for treating melanomas, colon cancer, pancreatic cancer, breast cancer, prostate cancer, lung cancer, leukemia, brain tumors, lymphoma, ovarian cancer and Kaposi's sarcoma, and are expected to be developed into a new generation of CD73 inhibitor drugs. (I)
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Inventors:
DENG HAIBING (CN)
ZHAO BAOWEI (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
ZHAO BAOWEI (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2018/123908
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07H19/16; A61K31/70; A61K31/7052; A61K31/7076; A61P35/00; C07H19/20; C07H19/207
Domestic Patent References:
| WO2018067424A1 | 2018-04-12 | |||
| WO2018208980A1 | 2018-11-15 | |||
| WO2017120508A1 | 2017-07-13 |
Foreign References:
| US9029346B1 | 2015-05-12 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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