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Title:
PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO/2011/039221
Kind Code:
A3
Abstract:
Compounds of formula I : including any possible stereoisomers thereof, wherein: R1 is hydrogen, -C(=O)R6 or -C(=O)CHR7-NH2; R2 is hydrogen; or C1-C6alkyl or phenyl, either of which is optionally substituted with 1, 2 or 3 substituents each independently selected from halo, C1-C6alkyl, C2-C6-alkenyl and C1-C6alkoxy, hydroxy or amino, or R2 is naphtyl; or R2 is indolyl, R3 is hydrogen, Ci-C6alkyl, benzyl; R4 is hydrogen, Ci-C6alkyl, benzyl; or R3 and R4 together with the carbon atom to which they are attached form C3-C7Cyclo- alkyl; R5 is C1-C10alkyl, C3-C7-cycloalkyl, benzyl, or phenyl, any of which being optionally substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C1-C6alkoxy, amino, mono- and diC1-C6alkylamino; R6 is C1-C6 alkyl; R7 is C1-C6 alkyl; R8 is hydrogen or halogen; or a pharmaceutically acceptable salt or solvate thereof are useful in the prophylaxis or treatment of HCV infections.

Inventors:
JONCKERS, Tim Hugo Maria (Pastoor Wouterstraat 19 bus 5, Edegem, B-2650, BE)
RABOISSON, Pierre Jean-Marie Bernard (Turnhoutseweg 30, Beerse, B-2340, BE)
VANDYCK, Koen (Deurnestraat 74, Paal-Beringen, B-3583, BE)
PELCMAN, Michael (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
SUND, Bengt Christian (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
WÄHLING, Horst Jürgen (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
PASSOS PINHO, Pedro Manuel (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
WINQVIST, Anna (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
NILSSON, Karl Magnus (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
Application Number:
EP2010/064413
Publication Date:
June 16, 2011
Filing Date:
September 29, 2010
Export Citation:
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Assignee:
Centocor Ortho Biotech Products L.P. (430 Route 22 East, Bridgewater, New Jersey, 08807, US)
MEDIVIR AB (P.O. Box 1086, Huddinge, S-141 22, SE)
JONCKERS, Tim Hugo Maria (Pastoor Wouterstraat 19 bus 5, Edegem, B-2650, BE)
RABOISSON, Pierre Jean-Marie Bernard (Turnhoutseweg 30, Beerse, B-2340, BE)
VANDYCK, Koen (Deurnestraat 74, Paal-Beringen, B-3583, BE)
PELCMAN, Michael (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
SUND, Bengt Christian (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
WÄHLING, Horst Jürgen (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
PASSOS PINHO, Pedro Manuel (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
WINQVIST, Anna (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
NILSSON, Karl Magnus (Medivir AB, P.O.Box 1086, Huddinge, S-141 22, SE)
International Classes:
C07H19/10; A61K31/7072; A61P31/14
Domestic Patent References:
WO2007020193A22007-02-22
WO2009067409A12009-05-28
Attorney, Agent or Firm:
DAELEMANS, Frank (Turnhoutseweg 30, Beerse, B-2340, BE)
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