Title:
PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDES
Document Type and Number:
WIPO Patent Application WO/2011/039221
Kind Code:
A3
Abstract:
Compounds of formula I : including any possible stereoisomers thereof, wherein: R1 is hydrogen, -C(=O)R6 or -C(=O)CHR7-NH2; R2 is hydrogen; or C1-C6alkyl or phenyl, either of which is optionally substituted with 1, 2 or 3 substituents each independently selected from halo, C1-C6alkyl, C2-C6-alkenyl and C1-C6alkoxy, hydroxy or amino, or R2 is naphtyl; or R2 is indolyl, R3 is hydrogen, Ci-C6alkyl, benzyl; R4 is hydrogen, Ci-C6alkyl, benzyl; or R3 and R4 together with the carbon atom to which they are attached form C3-C7Cyclo- alkyl; R5 is C1-C10alkyl, C3-C7-cycloalkyl, benzyl, or phenyl, any of which being optionally substituted with 1, 2 or 3 substituents each independently selected from hydroxy, C1-C6alkoxy, amino, mono- and diC1-C6alkylamino; R6 is C1-C6 alkyl; R7 is C1-C6 alkyl; R8 is hydrogen or halogen; or a pharmaceutically acceptable salt or solvate thereof are useful in the prophylaxis or treatment of HCV infections.
Inventors:
JONCKERS TIM HUGO MARIA (BE)
RABOISSON PIERRE JEAN-MARIE BERNARD (BE)
VANDYCK KOEN (BE)
PELCMAN MICHAEL (SE)
SUND BENGT CHRISTIAN (SE)
WAEHLING HORST JUERGEN (SE)
PASSOS PINHO PEDRO MANUEL (SE)
WINQVIST ANNA (SE)
NILSSON KARL MAGNUS (SE)
RABOISSON PIERRE JEAN-MARIE BERNARD (BE)
VANDYCK KOEN (BE)
PELCMAN MICHAEL (SE)
SUND BENGT CHRISTIAN (SE)
WAEHLING HORST JUERGEN (SE)
PASSOS PINHO PEDRO MANUEL (SE)
WINQVIST ANNA (SE)
NILSSON KARL MAGNUS (SE)
Application Number:
PCT/EP2010/064413
Publication Date:
June 16, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
CENTOCOR ORTHO BIOTECH PRODUCTS L P (US)
MEDIVIR AB (SE)
JONCKERS TIM HUGO MARIA (BE)
RABOISSON PIERRE JEAN-MARIE BERNARD (BE)
VANDYCK KOEN (BE)
PELCMAN MICHAEL (SE)
SUND BENGT CHRISTIAN (SE)
WAEHLING HORST JUERGEN (SE)
PASSOS PINHO PEDRO MANUEL (SE)
WINQVIST ANNA (SE)
NILSSON KARL MAGNUS (SE)
MEDIVIR AB (SE)
JONCKERS TIM HUGO MARIA (BE)
RABOISSON PIERRE JEAN-MARIE BERNARD (BE)
VANDYCK KOEN (BE)
PELCMAN MICHAEL (SE)
SUND BENGT CHRISTIAN (SE)
WAEHLING HORST JUERGEN (SE)
PASSOS PINHO PEDRO MANUEL (SE)
WINQVIST ANNA (SE)
NILSSON KARL MAGNUS (SE)
International Classes:
C07H19/10; A61K31/7072; A61P31/14
Domestic Patent References:
| WO2007020193A2 | 2007-02-22 | |||
| WO2009067409A1 | 2009-05-28 |
Attorney, Agent or Firm:
DAELEMANS, Frank (Beerse, BE)
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