PHOSPHORUS-CONTAINING COMPOUND, AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF

WIPO Patent Application WO/2024/067783

A1

Provided are a compound represented by formula (I), an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and use of the compound as an androgen receptor (AR) inhibitor.

DENG GANG (CN)
HUANG HUOMING (CN)
PENG JIANBIAO (CN)

PCT/CN2023/122463

April 04, 2024

September 28, 2023

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SHANGHAI JEMINCARE PHARMACEUTICAL CO LTD (CN)

C07F9/6512; A61K31/422; A61K31/4402; A61K31/4965; A61K31/506; A61K31/662; A61K31/675; A61P15/00; A61P17/00; A61P17/10; A61P17/14; A61P21/00; A61P35/00; C07D205/02; C07D207/12; C07D213/60; C07D233/54; C07D241/14; C07D263/34; C07D277/32; C07D403/02

WO2023121939A1	2023-06-29
WO2014070859A1	2014-05-08
WO2010151711A1	2010-12-29
WO2020228685A1	2020-11-19

CN116265453A	2023-06-20
US20020068721A1	2002-06-06
CN101977906A	2011-02-16
CN105283443A	2016-01-27
CN115087440A	2022-09-20
CN114437062A	2022-05-06
CN105814067A	2016-07-27

DATABASE Registry 19 October 2022 (2022-10-19), ANONYMOUS : "Ethanone, 1-[6-[[5-chloro-4-[[[2-(dimethylphosphinyl)phenyl]methyl]amino]- 2-pyrimidinyl]amino]-2,3-dihydro-5-methoxy-1H-indol-1-yl]-2- (dimethylamino)- (CA INDEX NAME)", XP093151626, retrieved from STNext Database accession no. 2841304-07-0
DATABASE Registry 16 February 2022 (2022-02-16), ANONYMOUS : "3(4H)-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3- fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1-[(phosphonooxy)methyl]- (CA INDEX NAME)", XP093151627, retrieved from STNext Database accession no. 1174161-69-3

SHANGHAI BESHINING LAW OFFICE (CN)

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