Title:
PHOTODEGRADABLE CELL IMMOBILIZATION AGENT
Document Type and Number:
WIPO Patent Application WO/2019/088258
Kind Code:
A1
Abstract:
[Problem] To develop a photodegradable cell immobilization agent having superior cell immobilization ability. [Solution] This photodegradable cell immobilization agent is for immobilizing a predetermined target cell onto a base material, the agent being characterized by comprising a hydrophobic chain capable of interacting with the target cell, a hydrophilic chain capable of being arrayed into a monomolecular film on a surface of the base material, and a hydrophilic linker and a photodegradable linker which link the hydrophobic chain and the hydrophilic chain together, wherein the hydrophilic linker is positioned between the hydrophobic chain and the photodegradable linker.
Inventors:
YAMAGUCHI SATOSHI (JP)
OKAMOTO AKIMITSU (JP)
JARZEBSKA NATALIA TERESA (JP)
IZUTA SHIN (JP)
YAMAHIRA SHINYA (JP)
NAGAMUNE TERUYUKI (JP)
OKAMOTO AKIMITSU (JP)
JARZEBSKA NATALIA TERESA (JP)
IZUTA SHIN (JP)
YAMAHIRA SHINYA (JP)
NAGAMUNE TERUYUKI (JP)
Application Number:
PCT/JP2018/040853
Publication Date:
May 09, 2019
Filing Date:
November 02, 2018
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N11/02; C08G65/332; C12N11/08
Domestic Patent References:
| WO2016158327A1 | 2016-10-06 |
Foreign References:
| JP2008125952A | 2008-06-05 |
Other References:
YAMAGUCHI, S. ET AL.: "Photocontrollable dynamic micropatterning of non-adherent mammalian cells using a photocleavable poly (ethylene glycol) lipid", ANGEW. CHEM. INT. ED., vol. 51, 2012, pages 128 - 131, XP055602106
YAMAHIRA, S. ET AL.: "Collagen surfaces modified with photo-cleavable polyethylene glycol-lipid support versatile single- cell arrays of both non- adherent and adherent cells", MACROMOL. BIOSCI., vol. 14, 2014, pages 1670 - 1676, XP55612997
NAGAMUNE, TERUYUKI: "Development of microchip for identifying and separating tumor cells circulating in blood", 2015 RESEARCH PERFORMANCE REPORT ON SCIENTIFIC RESEARCH FUND- RAISING BUSINESS, 10 May 2017 (2017-05-10)
YAMAGUCHI, SATOSHI ET AL.: "35.1 Development of photoresponsive cell -fixing agent, aiming at cell operation", LECTURE ABSTRACTS OF THE 28TH BIO AND POLYMER SYMPOSIUM, 20 July 2018 (2018-07-20), pages 155 - 156
YAMAHIRA, S. ET AL.: "Collagen surfaces modified with photo-cleavable polyethylene glycol-lipid support versatile single- cell arrays of both non- adherent and adherent cells", MACROMOL. BIOSCI., vol. 14, 2014, pages 1670 - 1676, XP55612997
NAGAMUNE, TERUYUKI: "Development of microchip for identifying and separating tumor cells circulating in blood", 2015 RESEARCH PERFORMANCE REPORT ON SCIENTIFIC RESEARCH FUND- RAISING BUSINESS, 10 May 2017 (2017-05-10)
YAMAGUCHI, SATOSHI ET AL.: "35.1 Development of photoresponsive cell -fixing agent, aiming at cell operation", LECTURE ABSTRACTS OF THE 28TH BIO AND POLYMER SYMPOSIUM, 20 July 2018 (2018-07-20), pages 155 - 156
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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