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Patent Searching and Data


Title:
PHOTON COUNTING AND SPECTROSCOPY
Document Type and Number:
WIPO Patent Application WO/2018/191497
Kind Code:
A3
Abstract:
A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.

Inventors:
YAMAMOTO MASANOBU (US)
HERNANDEZ KEEGAN (US)
ROBINSON J (US)
Application Number:
PCT/US2018/027302
Publication Date:
November 15, 2018
Filing Date:
April 12, 2018
Export Citation:
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Assignee:
CAPTL LLC (US)
International Classes:
G01J3/02; G01J3/18; G01J3/44; G01N21/64
Domestic Patent References:
WO2015073384A12015-05-21
WO2013093726A12013-06-27
Foreign References:
US20070002325A12007-01-04
US20060262309A12006-11-23
Other References:
SOUKKA J M ET AL: "OPTIMIZATION OF MULTI-PHOTON EVENT DISCRIMINATION LEVELS USING POISSON STATISTICS", OPTICS EXPRESS, OSA PUBLISHING, US, vol. 12, no. 1, 12 November 2004 (2004-11-12), pages 84 - 89, XP008079832, ISSN: 1094-4087, DOI: 10.1364/OPEX.12.000084
MICHAEL WAHL: "The Principle of Time-Correlated Single Photon Counting", PICOQUANT TECHNICAL NOTE, 24 June 2014 (2014-06-24), pages 1 - 14, XP055135297, Retrieved from the Internet [retrieved on 20140819]
Attorney, Agent or Firm:
WHITE, Christopher, J. et al. (US)
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