Title:
PHOTOOXYGENATION CATALYST COMPOUND HAVING PHENOTHIAZINE SKELETON AND MEDICINE CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2021/145368
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of developing a photocatalyst compound that is capable of efficiently oxygenating amyloids in a low aggregation state and at a low concentration and that could reduce cytotoxicity under light irradiation, and, furthermore, the purpose of the present invention is to provide a prophylactic/therapeutic agent for amyloid-related diseases employing said novel photocatalyst compound. [Solution] It has been shown that it is possible to selectively oxygenate amyloids by means of light irradiation while suppressing stacking of catalyst molecules on each other and reducing cytotoxicity as a result of employing a photocatalyst compound having a mother skeleton in which a phenothiazine structure and a morpholine structure are joined and in which a side chain having a specific structure is also introduced. In addition, it has been shown that said compound is capable of efficiently oxygenating amyloids in a low aggregation state and at a low concentration.
Inventors:
SOHMA YOUHEI (JP)
KANAI MOTOMU (JP)
KINO RYUTO (JP)
OI MIKU (JP)
KANAI MOTOMU (JP)
KINO RYUTO (JP)
OI MIKU (JP)
Application Number:
PCT/JP2021/001008
Publication Date:
July 22, 2021
Filing Date:
January 14, 2021
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61P25/14; A61P25/16; A61P25/28; C07D513/04; A61K31/5415
Domestic Patent References:
| WO2016010092A1 | 2016-01-21 | |||
| WO2020023911A2 | 2020-01-30 |
Other References:
TANG, H. ET AL.: "Novel oxoisoaporphine-based inhibitors of acetyl-and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 2012, pages 2257 - 2261, XP028402852, DOI: 10.1016/j.bmcl.2012.01.090
TANIGUCHI, ATSUHIKO: "Amyloid-selective photooxygenation toward treatment for amyloid diseases", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 138, no. 1, 2018, pages 47 - 53, XP055843237
ATSUHIKO TANIGUCHI, YUSUKE SHIMIZU, KOUNOSUKE OISAKI, YOUHEI SOHMA, MOTOMU KANAI: "Switchable photooxygenation catalysts that sense higher-order amyloid structures", NATURE CHEMISTRY, vol. 8, 2016, pages 974 - 982, XP055843239
TANIGUCHI, ATSUHIKO: "Amyloid-selective photooxygenation toward treatment for amyloid diseases", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 138, no. 1, 2018, pages 47 - 53, XP055843237
ATSUHIKO TANIGUCHI, YUSUKE SHIMIZU, KOUNOSUKE OISAKI, YOUHEI SOHMA, MOTOMU KANAI: "Switchable photooxygenation catalysts that sense higher-order amyloid structures", NATURE CHEMISTRY, vol. 8, 2016, pages 974 - 982, XP055843239
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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