PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF

WIPO Patent Application WO/2017/101796

A1

The present application relates to a phthalazinone derivative, and a preparation method and a use thereof. In particular, the present application relates to a compound of formula I, and a prodrug, a metabolite form, a pharmaceutically acceptable salt or an ester thereof, or isomers, hydrates, solvates or crystalline forms of the above-mentioned items, and a preparation method and use thereof. The compounds of the present application can significantly enhance the inhibitory effect on the proliferation of tumour cells; and can increase the stability of molecules in vivo and reduce the possibility of producing toxic metabolites; or can reduce the oxidative metabolic capability of compounds under the action of a P450 cytochrome enzyme system in vivo by reducing the structural modification of the phthalazinone compounds, and can improve the bioavailability.

LIU GANG (CN)
YU HUA (CN)
REN YUN (CN)
DU JING (CN)
YANG DINGJU (CN)
LI XIAOYONG (CN)
WANG KUNJIAN (CN)
LIU WEI (CN)
TANG JIANCHUAN (CN)
WU YONGYONG (CN)
ZENG HONG (CN)
QING YAN (CN)
SONG HONGMEI (CN)
LI SHAOHUA (CN)
GE YONG (CN)
WANG LICHUN (CN)
WANG JINGYI (CN)

PCT/CN2016/110007

June 22, 2017

December 15, 2016

Click for automatic bibliography generation  

SICHUAN KELUN-BIOTECH BIOPHARMACEUTICA CO LTD (CN)

C07D471/04; A61K31/502; A61K31/551; A61P9/00; A61P25/00; A61P35/00; C07D471/14; C07D487/04

WO2012019427A1	2012-02-16
WO2014102817A1	2014-07-03
WO2014019468A1	2014-02-06
WO2012072033A1	2012-06-07
WO2012019426A1	2012-02-16

CN102898377A

2013-01-30

CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)

View/Download PDF      PDF Help

Previous Patent: BI-FUNCTIONAL ELECTRODE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Next Patent: INK PEN