Title:
PHYSICAL AND CHEMICAL DOUBLE CROSS-LINKED NETWORK HIGH-STRENGTH GELATIN HYDROGEL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/156291
Kind Code:
A1
Abstract:
The present invention relates to a physical and chemical double cross-linked network high-strength gelatin hydrogel and a preparation method therefor, comprising: using Traut's reagent and methacrylic anhydride reagent to respectively perform modification of gelatin and chitosan; preparing a hydrogel; and using a method of alkaline sulphate solution immersion to introduce physical and chemical cross-linking to obtain a double cross-linked network high-strength gelatin-chitosan hydrogel. The present invention uses a physical and chemical double cross-linking method to obtain the high-strength gelatin-chitosan hydrogel; the method is simple and convenient, fast and efficient, and avoids the use of synthetic polymers and toxic cross-linking agents; and the obtained high-strength gelatin-chitosan hydrogel has excellent mechanical properties and biocompatibility. The present invention provides a new idea and method for preparing a high-strength biocompatible protein-based hydrogel, and helps broaden the scope of application of protein-based hydrogel materials in fields such as biomaterials and tissue engineering.
Inventors:
WANG SHAOYUN (CN)
HE QINGYAN (CN)
HUANG YAN (CN)
CHEN HUIMIN (CN)
HE QINGYAN (CN)
HUANG YAN (CN)
CHEN HUIMIN (CN)
Application Number:
PCT/CN2020/073067
Publication Date:
August 06, 2020
Filing Date:
January 19, 2020
Export Citation:
Assignee:
UNIV FU ZHOU (CN)
International Classes:
C08J3/075; C08B37/08; C08H1/00; C08J3/24; C08L5/08
Foreign References:
| CN109749098A | 2019-05-14 | |||
| CN101721349A | 2010-06-09 | |||
| CN107929804A | 2018-04-20 | |||
| CN108014754A | 2018-05-11 | |||
| EP2523656A1 | 2012-11-21 | |||
| EP3383447A1 | 2018-10-10 |
Attorney, Agent or Firm:
FUZHOU YUANCHUANG PATENT AND TRADEMARK AGENT LTD. (CN)
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