Title:
PHYTOCHEMICAL-FRUCTOOLIGOSACCHARIDE CONJUGATE, METHOD FOR PRODUCING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/091423
Kind Code:
A1
Abstract:
The present invention provides a novel phytochemical-fructooligosaccharide conjugate having a structure in which a phytochemical in the form of phenolic acid is conjugated to a portion of saccharides constituting a fructooligosaccharide backbone. Compared to corresponding phenolic acid phytochemicals, the novel phytochemical-fructooligosaccharide conjugate according to the present invention is hardly decomposed under oral-gastrointestinal transit conditions such that most of the phytochemical-fructooligosaccharide conjugate can reach the large intestine. Thus, the novel phytochemical-fructooligosaccharide conjugate has good bioavailability in the large intestine when orally administered. In particular, a ferulic acid-fructooligosaccharide conjugate according to the present invention has an excellent colorectal cancer cell-selective killing effect as compared to commercial colorectal cancer treatment drugs, and can thus be used as a food or pharmaceutical material useful for preventing, alleviating, or treating colorectal cancer.
Inventors:
SUH JOO WON (KR)
MALIYAKKAL JOHNSON ELDIN (IN)
LEE HAN KI (KR)
MALIYAKKAL JOHNSON ELDIN (IN)
LEE HAN KI (KR)
Application Number:
PCT/KR2019/014489
Publication Date:
May 07, 2020
Filing Date:
October 30, 2019
Export Citation:
Assignee:
MYONGJI UNIV INDUSTRY AND ACADEMIA COOPERATION FOUNDATION (KR)
International Classes:
C07H3/06; A23L29/00; A23L33/10; A61P35/00; B01J31/02; C07H1/00
Foreign References:
| JP2007106724A | 2007-04-26 | |||
| JP2012187099A | 2012-10-04 | |||
| JPS59792B2 | 1984-01-09 | |||
| JP2006089437A | 2006-04-06 |
Other References:
MESAIK, M. A.: "In silico and in vitro immunomodulatory studies on compounds of Lindelofia stylosa", CHEM BIOL DRUG DES, vol. 79, no. 3, 2012, pages 290 - 299, XP55704750
KAMIJO, T.: "An Improved and Convenient Synthesis of Esters Using 1,1'-Carbonyldiimidazole and a Reactive Halide", CHEM. PHARM. BULL., 1984, pages 5044 - 5047, XP55704755
LEE, S. Y.: "A new phenylpropane glycoside from the rhizome of Sparganium stoloniferum", ARCH PHARM RES, 2010, pages 515 - 521, XP55704760
CESARE MANCUSO ET AL.: "Ferulic acid: Pharmacological and toxicological aspects", FOOD AND CHEMICAL TOXICOLOGY, vol. 65, 2014, pages 185 - 195, XP028610011, DOI: 10.1016/j.fct.2013.12.024
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
KAMIJO, T.: "An Improved and Convenient Synthesis of Esters Using 1,1'-Carbonyldiimidazole and a Reactive Halide", CHEM. PHARM. BULL., 1984, pages 5044 - 5047, XP55704755
LEE, S. Y.: "A new phenylpropane glycoside from the rhizome of Sparganium stoloniferum", ARCH PHARM RES, 2010, pages 515 - 521, XP55704760
CESARE MANCUSO ET AL.: "Ferulic acid: Pharmacological and toxicological aspects", FOOD AND CHEMICAL TOXICOLOGY, vol. 65, 2014, pages 185 - 195, XP028610011, DOI: 10.1016/j.fct.2013.12.024
"Remington's Pharmaceutical Science", MACK PUBLISHING COMPANY
Attorney, Agent or Firm:
LIM, Sang Yeob (KR)
Download PDF: