Title:
PICHIA CIFERRII MUTANT STRAIN HAVING IMPROVED SPHINGOLIPID AND SPHINGOID BASE PRODUCTIVITY, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/261816
Kind Code:
A1
Abstract:
The present invention relates to a novel yeast mutant strain for producing a ceramide precursor, and a preparation method therefor, and, more specifically, to: a Pichia ciferrii mutant strain genetically engineered to overexpress sphingolipid metabolites prepared through the reconstruction of metabolic pathways for ceramide production in Pichia ciferrii; or a method for preparing the mutant strain.
Inventors:
AHN JUNG OH (KR)
HAN CHANG PYO (KR)
JANG MIN JEONG (KR)
KWON HEE UN (KR)
LEE TAE HEE (KR)
LEE JU HEE (KR)
KIM HYE JIN (KR)
HAN CHANG PYO (KR)
JANG MIN JEONG (KR)
KWON HEE UN (KR)
LEE TAE HEE (KR)
LEE JU HEE (KR)
KIM HYE JIN (KR)
Application Number:
PCT/KR2021/007298
Publication Date:
December 30, 2021
Filing Date:
June 10, 2021
Export Citation:
Assignee:
KOREA RES INSTITUTE OF BIOSCIENCE & BIOTECHNOLOGY (KR)
SOLUS ADVANCED MAT CO LTD (KR)
SOLUS ADVANCED MAT CO LTD (KR)
International Classes:
C12N15/81; C12N15/10; C12P13/02
Domestic Patent References:
| WO2007131720A1 | 2007-11-22 |
Foreign References:
| US20150353966A1 | 2015-12-10 | |||
| JP2018519843A | 2018-07-26 | |||
| KR20200076795A | 2020-06-30 | |||
| KR100221357B1 | 1999-10-01 | |||
| KR100188857B1 | 1999-06-01 | |||
| KR102056651B1 | 2019-12-17 |
Other References:
CHRISTOPH SCHORSCH, TIM KÖHLER, HEIKO ANDREA, ECKHARD BOLES: "High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii", METABOLIC ENGINEERING, vol. 14, no. 2, 1 March 2012 (2012-03-01), pages 172 - 184, XP055038100, ISSN: 10967176, DOI: 10.1016/j.ymben.2011.12.002
LEE HEESEOK, HAN CHANGPYO, LEE HYEOK-WON, PARK GYUYEON, JEON WOOYOUNG, AHN JUNGOH, LEE HONGWEON: "Development of a promising microbial platform for the production of dicarboxylic acids from biorenewable resources", BIOTECHNOLOGY FOR BIOFUELS, vol. 11, no. 1, 1 December 2018 (2018-12-01), pages 1 - 14, XP055800830, DOI: 10.1186/s13068-018-1310-x
KLUG LISA, DAUM GÜNTHER: "Yeast lipid metabolism at a glance", FEMS YEAST RESEARCH, vol. 14, no. 3, 1 May 2014 (2014-05-01), GB, NL , pages 369 - 388, XP055882732, ISSN: 1567-1356, DOI: 10.1111/1567-1364.12141
CURRENT ORGANIC CHEMISTRY, vol. 14, no. 20, 2010, pages 2483 - 2521
JOURNAL OF BACTERIOLOGY, vol. 80, no. 4, 1960, pages 484 - 491
EUKARYOTIC CELL, vol. 11, no. 12, 2012, pages 1582
APPLIED MICROBIOLOGY, vol. 10, no. 5, 1962, pages 401
SCIENCE, vol. 292, no. 5516, 2001, pages 504
BIOCHIMICA ET BIOPHYSICA ACTA(BBA) -LIPIDS AND LIPID METABOLISM, vol. 306, no. 2, 1973, pages 341 - 345
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) -LIPIDS AND LIPID METABOLISM, vol. 306, no. 2, 1973, pages 341 - 345
YEAST, vol. 12, no. 14, 1996, pages 1439 - 1457
LEE HEESEOK, HAN CHANGPYO, LEE HYEOK-WON, PARK GYUYEON, JEON WOOYOUNG, AHN JUNGOH, LEE HONGWEON: "Development of a promising microbial platform for the production of dicarboxylic acids from biorenewable resources", BIOTECHNOLOGY FOR BIOFUELS, vol. 11, no. 1, 1 December 2018 (2018-12-01), pages 1 - 14, XP055800830, DOI: 10.1186/s13068-018-1310-x
KLUG LISA, DAUM GÜNTHER: "Yeast lipid metabolism at a glance", FEMS YEAST RESEARCH, vol. 14, no. 3, 1 May 2014 (2014-05-01), GB, NL , pages 369 - 388, XP055882732, ISSN: 1567-1356, DOI: 10.1111/1567-1364.12141
CURRENT ORGANIC CHEMISTRY, vol. 14, no. 20, 2010, pages 2483 - 2521
JOURNAL OF BACTERIOLOGY, vol. 80, no. 4, 1960, pages 484 - 491
EUKARYOTIC CELL, vol. 11, no. 12, 2012, pages 1582
APPLIED MICROBIOLOGY, vol. 10, no. 5, 1962, pages 401
SCIENCE, vol. 292, no. 5516, 2001, pages 504
BIOCHIMICA ET BIOPHYSICA ACTA(BBA) -LIPIDS AND LIPID METABOLISM, vol. 306, no. 2, 1973, pages 341 - 345
BIOCHIMICA ET BIOPHYSICA ACTA (BBA) -LIPIDS AND LIPID METABOLISM, vol. 306, no. 2, 1973, pages 341 - 345
YEAST, vol. 12, no. 14, 1996, pages 1439 - 1457
Attorney, Agent or Firm:
KIM, Sung Ho (KR)
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