Title:
PICRORHIZAE RHIZOMA CUCURBITANE SAPONIN EXTRACT AND USE THEREOF IN PREPARATION OF DRUG FOR TREATING CONSTIPATION
Document Type and Number:
WIPO Patent Application WO/2023/231582
Kind Code:
A1
Abstract:
Provided are a Picrorhizae rhizoma cucurbitane saponin extract and the use thereof in the preparation of a drug for treating constipation. Based on activity guidance, the cucurbitane saponin is found to be an effective Picrorhizae rhizoma part for purgative, and contains 10 cucurbitane tetracyclic triterpenoid saponins with 2β-glucopyranosyloxy-3,16,20,25-tetrahydroxy-9-methyl-19-norlanosta as a parent nucleus structure, wherein the sum of the contents of the 10 cucurbitane tetracyclic triterpenoid saponins is higher than 50%, and the cucurbitane saponin contains no iridoid ingredient. The compound 2β-glucopyranosyloxy-3,16,20-trihydroxy-9-methyl-19-norlanosta-5,25-diene-22-one is a newly discovered cucurbitane tetracyclic triterpenoid saponin. Pharmacological research shows that the Picrorhizae rhizoma cucurbitane saponin extract can promote defecation of normal and constipated model mice, and increase the water content of feces. The extract can be used for preparing a drug for treating constipation.
Inventors:
JI HAIJIE (CN)
HAO SHULAN (CN)
WANG XIXING (CN)
TONG LIGUO (CN)
WANG RUOYU (CN)
WANG XIAOLING (CN)
LI ZHONGYUN (CN)
WANG SHUMIN (CN)
HAO SHULAN (CN)
WANG XIXING (CN)
TONG LIGUO (CN)
WANG RUOYU (CN)
WANG XIAOLING (CN)
LI ZHONGYUN (CN)
WANG SHUMIN (CN)
Application Number:
PCT/CN2023/087473
Publication Date:
December 07, 2023
Filing Date:
April 11, 2023
Export Citation:
Assignee:
SHANXI ACAD OF TRADITIONAL CHINESE MEDICINE SHANXI PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICI (CN)
International Classes:
C07J17/00; A61K31/58; A61P1/10
Foreign References:
| CN114891058A | 2022-08-12 | |||
| US20080207578A1 | 2008-08-28 | |||
| CN1298705A | 2001-06-13 |
Other References:
STURM SONJA, STUPPNER HERMANN: "Analysis of cucurbitacins in medicinal plants by high-pressure liquid chromatography-mass spectrometry", PHYTOCHEMICAL ANALYSIS, J. WILEY, HOBOKEN, USA, vol. 11, no. 2, 1 March 2000 (2000-03-01), Hoboken, USA, pages 121 - 127, XP093116934, ISSN: 0958-0344, DOI: 10.1002/(SICI)1099-1565(200003/04)11:2<121::AID-PCA493>3.0.CO;2-9
H. F. SMIT, A. J. J. VAN DEN BERG, B. H. KROES, C. J. BEUKELMAN, H. C. QUARLES VAN UFFORD, H. VAN DIJK, AND R. P. LABADIE: "Inhibition of T-Lymphocyte Proliferation by Cucurbitacins from Picrorhiza scrophulariaeflora.", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 9, 1 September 2000 (2000-09-01), US , pages 1300 - 1302, XP008162486, ISSN: 0163-3864, DOI: 10.1021/np990215q
LANG KAREN L, GUIMARAES TATIANA, MACHADO VANESSA ROCHA, ZIMMERMANN LARA A, SILVA IZABELLA T, TEIXEIRA MARINA R, DURAN FERNANDO J, : "New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn", PLANTA MEDICA, THIEME VERLAG, DE, vol. 77, no. 14, 1 September 2011 (2011-09-01), DE , pages 1648 - 1651, XP093116935, ISSN: 0032-0943, DOI: 10.1055/s-0030-1270962
LI ZHEN‐JIE, CHEN JIAN‐CHAO, SUN YUN, SONG NA‐LI, CHENG BAO‐HUI, LU LU, MA WEI‐GUANG, ZHOU LIN, ZHANG XIAN‐MIN, LI ZHONG‐RONG, QIU: "Three New Triterpene Saponins from Hemsleya chinensis", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., HOBOKEN, USA, vol. 92, no. 9, 1 September 2009 (2009-09-01), Hoboken, USA, pages 1853 - 1859, XP093116936, ISSN: 0018-019X, DOI: 10.1002/hlca.200900060
H. F. SMIT, A. J. J. VAN DEN BERG, B. H. KROES, C. J. BEUKELMAN, H. C. QUARLES VAN UFFORD, H. VAN DIJK, AND R. P. LABADIE: "Inhibition of T-Lymphocyte Proliferation by Cucurbitacins from Picrorhiza scrophulariaeflora.", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 9, 1 September 2000 (2000-09-01), US , pages 1300 - 1302, XP008162486, ISSN: 0163-3864, DOI: 10.1021/np990215q
LANG KAREN L, GUIMARAES TATIANA, MACHADO VANESSA ROCHA, ZIMMERMANN LARA A, SILVA IZABELLA T, TEIXEIRA MARINA R, DURAN FERNANDO J, : "New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn", PLANTA MEDICA, THIEME VERLAG, DE, vol. 77, no. 14, 1 September 2011 (2011-09-01), DE , pages 1648 - 1651, XP093116935, ISSN: 0032-0943, DOI: 10.1055/s-0030-1270962
LI ZHEN‐JIE, CHEN JIAN‐CHAO, SUN YUN, SONG NA‐LI, CHENG BAO‐HUI, LU LU, MA WEI‐GUANG, ZHOU LIN, ZHANG XIAN‐MIN, LI ZHONG‐RONG, QIU: "Three New Triterpene Saponins from Hemsleya chinensis", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA., HOBOKEN, USA, vol. 92, no. 9, 1 September 2009 (2009-09-01), Hoboken, USA, pages 1853 - 1859, XP093116936, ISSN: 0018-019X, DOI: 10.1002/hlca.200900060
Attorney, Agent or Firm:
TAIYUAN JINKE INTELLECTUAL PROPERTY ATTORNEY LAW OFFICE (SPECIAL GENERAL PARTNERSHIP) (CN)
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