Title:
PIGMENT-COUPLED MANNOSYL SERUM ALBUMIN COMPLEX AND LYMPH NODE-PROBING COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2018/169356
Kind Code:
A1
Abstract:
The present invention relates to a pigment-coupled mannosyl serum albumin complex and a lymph node-probing composition comprising the same. More particularly, when administered to mice, a pigment-coupled mannosyl serum albumin complex can be observed with the naked eye to exist in a condense state for a long period of time in the inguinal lymph node. Thus, the complex and a composition comprising the same can be useful for probing lymph nodes.
Inventors:
JEONG JAE MIN (KR)
LEE YUN-SANG (KR)
LEE JI YOUN (KR)
LEE YUN-SANG (KR)
LEE JI YOUN (KR)
Application Number:
PCT/KR2018/003106
Publication Date:
September 20, 2018
Filing Date:
March 16, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K51/08; A61B5/00; A61K51/04
Domestic Patent References:
| WO2000074727A2 | 2000-12-14 |
Foreign References:
| KR20160020296A | 2016-02-23 | |||
| KR100557008B1 | 2006-03-03 | |||
| KR20160020296A | 2016-02-23 |
Other References:
JEONG, J. M. ET AL.: "Development of 99mTc-neomannosyl Human Serum Albumin (99mTc-MSA) as a Novel Receptor Binding Agent for Sentinel Lymph Node Imaging", NUCLEAR MEDICINE COMMUNICATIONS, vol. 25, 2004, pages 1211 - 1217, XP008158775
LANDEL, A. M.: "Stability Studies on Fluorescein Isothiocyanate-bovine Serum Albumin Conjugate", ANALYTICAL BIOCHEMISTRY, vol. 73, 1976, pages 280 - 289, XP024816888
CHUANG, P. -T. ET AL.: "Macromolecular Transport across Arterial and Venous Endothelium in Rats: Studies with Evans Blue-albumin and Horseradish Peroxidase", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 10, no. 2, 1990, pages 188 - 197, XP055548212
See also references of EP 3597224A4
LANDEL, A. M.: "Stability Studies on Fluorescein Isothiocyanate-bovine Serum Albumin Conjugate", ANALYTICAL BIOCHEMISTRY, vol. 73, 1976, pages 280 - 289, XP024816888
CHUANG, P. -T. ET AL.: "Macromolecular Transport across Arterial and Venous Endothelium in Rats: Studies with Evans Blue-albumin and Horseradish Peroxidase", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 10, no. 2, 1990, pages 188 - 197, XP055548212
See also references of EP 3597224A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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