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Patent Searching and Data


Title:
PIPER AMIDE-BASED COMPOUND AS BOMBESIN RECEPTOR SUBTYPE 3
Document Type and Number:
WIPO Patent Application WO/2014/129874
Kind Code:
A1
Abstract:
The present invention relates to: a novel α,β-unsaturated amide compound; a method for preparing a composition for preventing or treating obesity, comprising the steps of selecting a compound showing an obesity prevention or treatment effect from a compound library comprising one or more α,β-unsaturated amide compounds, and preparing a composition for preventing or treating obesity containing the selected compound; and a composition for preventing or treating obesity, containing an α,β-unsaturated amide compound. The α,β-unsaturated amide compound of the present invention has a mother nucleus structure mimicking a piper amide, which is a natural substance showing various activities, and can show various pharmacological activities. In addition, a pure compound can be obtained without carrying out a purification process by column chromatography normally used since soluble by-products are generated using β-phosphono-N-hydroxysuccinimidyl ester as an intermediate. Additionally, it is possible to screen a compound, which is a BRS-3 agonist, from a library of the compound synthesized thereby through a pharmacological activity test, and utilize the same in a composition for preventing or treating obesity.

Inventors:
KIM SANG HEE (KR)
LIM CHAE MIN (KR)
KIM SU MIN (KR)
KANG KEON WOOK (KR)
Application Number:
PCT/KR2014/001521
Publication Date:
August 28, 2014
Filing Date:
February 25, 2014
Export Citation:
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Assignee:
SNU R&DB FOUNDATION (KR)
International Classes:
C07D307/52; C07C233/11; C07D307/36
Foreign References:
CN101274901B2010-06-23
Other References:
HUANG, HUNG-JIN ET AL.: "Computational screening and QSAR analysis for design of AMP-activated protein kinase agonist", JOURNAL OF THE TAIWAN INSTITIITE OF CHEMICAL ENGINEERS, vol. 41, 2010, pages 352 - 359, XP027036375
YANG, JOHN ET AL.: "Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, 2010, pages 5032 - 5038
CHERKASOV, ARTEM ET AL.: "Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 24, 2011, pages 8563 - 8573
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
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