Title:
PIPERAZINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/024993
Kind Code:
A1
Abstract:
Provided is a compound having an antagonistic activity on an arginine-vasopressin 1b receptor. A compound represented by general formula (I) [wherein each symbol is as defied in the description] or a salt thereof has an antagonistic activity on an arginine-vasopressin 1b receptor.
Inventors:
TAKASU KIYOSEI (JP)
OKUNO YASUSHI (JP)
SEGI ERI (JP)
HARA TAKAFUMI (JP)
FUJIMURA SHUN (JP)
YAMAMOTO YOSHIHIRO (JP)
KANAI CHISATO (JP)
YOSHIKAWA TATSUYA (JP)
NEYA MASAHIRO (JP)
KOHNO SHINYA (JP)
OKUNO YASUSHI (JP)
SEGI ERI (JP)
HARA TAKAFUMI (JP)
FUJIMURA SHUN (JP)
YAMAMOTO YOSHIHIRO (JP)
KANAI CHISATO (JP)
YOSHIKAWA TATSUYA (JP)
NEYA MASAHIRO (JP)
KOHNO SHINYA (JP)
Application Number:
PCT/JP2013/071557
Publication Date:
February 13, 2014
Filing Date:
August 08, 2013
Export Citation:
Assignee:
UNIV KYOTO (JP)
KYOTO CONSTELLA TECHNOLOGIES CO LTD (JP)
KNC LAB CO LTD (JP)
KYOTO CONSTELLA TECHNOLOGIES CO LTD (JP)
KNC LAB CO LTD (JP)
International Classes:
C07D207/16; A61K31/496; A61K31/55; A61P1/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D211/60; C07D401/06; C07D403/06
Foreign References:
| JPH08502474A | 1996-03-19 | |||
| JP2010024164A | 2010-02-04 | |||
| JP2012505237A | 2012-03-01 | |||
| JP2009542664A | 2009-12-03 | |||
| JP2009542666A | 2009-12-03 |
Other References:
NOBUAKI EGASHIRA ET AL.: "Role of vasopressin receptor in psychological and cognitive functions", FOLIA PHARMACOLOGICA JAPONICA, vol. 134, no. 1, 2009, pages 3 - 7
EGASHIRA,N. ET AL.: "New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 109, no. 1, 2009, pages 44 - 49
JIANG,W. ET AL.: "Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 23, 2007, pages 6546 - 6552
EGASHIRA,N. ET AL.: "New topics in vasopressin receptors and approach to novel drugs: role of the vasopressin receptor in psychological and cognitive functions", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 109, no. 1, 2009, pages 44 - 49
JIANG,W. ET AL.: "Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 23, 2007, pages 6546 - 6552
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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