Title:
PIPERAZINE DERIVATIVES AS 5-HT1A ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/1993/011122
Kind Code:
A1
Abstract:
Compounds of formula (I) where A is a C1 or C2 alkylene chain optionally substituted by lower alkyl, Z is a bicyclic oxygen-containing radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl), R is hydrogen or lower alkyl, R1 is aryl or aryl(lower)alkyl and R2 and R3 are specified groups, and the pharmaceutically acceptable acid addition salts are novel. They are 5-HT1A-antagonists which may be used, for example, in treating anxiety.
Inventors:
CLIFFE IAN ANTHONY (GB)
Application Number:
PCT/GB1992/002228
Publication Date:
June 10, 1993
Filing Date:
December 01, 1992
Export Citation:
Assignee:
WYETH JOHN & BROTHER LTD (GB)
International Classes:
A61K31/34; A61K31/343; A61K31/35; A61K31/335; A61K31/352; A61K31/353; A61K31/357; A61K31/39; A61K31/535; A61K31/538; A61K31/55; A61P9/12; A61P13/02; A61P15/00; A61P25/00; A61P25/20; A61P25/24; A61P25/26; A61P43/00; C07D265/36; C07D295/10; C07D307/79; C07D311/08; C07D311/20; C07D311/22; C07D311/58; C07D317/46; C07D317/66; C07D319/18; C07D319/20; C07D321/10; C07D327/06; C07D405/02; C07D405/04; C07D411/02; C07D413/02; (IPC1-7): A61K31/335; C07D319/18
Foreign References:
| GB2230781A | 1990-10-31 | |||
| EP0481744A1 | 1992-04-22 | |||
| EP0138280A2 | 1985-04-24 |
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