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Title:
PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR TREATING CENTRAL NERVOUS SYSTEM (CNS) DISORDERS
Document Type and Number:
WIPO Patent Application WO2002044142
Kind Code:
A3
Abstract:
Novel piperazine derivatives are provided having the formula (III) wherein R>1< is cyano, notro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT>1A< receptor antagonists.

Inventors:
CHILDERS WAYNE EVERETT
KELLY MICHAEL GERARD
ROSENZWEIG-LIPSON SHARON JOY
Application Number:
US0143160W
Publication Date:
August 08, 2002
Filing Date:
November 27, 2001
Export Citation:
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Assignee:
WYETH
International Classes:
A61K31/496; A61P1/14; A61P5/00; A61P9/00; A61P13/02; A61P15/10; A61P25/00; A61P25/06; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P43/00; C07B55/00; C07B57/00; C07D405/12; (IPC1-7): A61K31/44; C07D405/12; A61P25/28
Domestic Patent References:
WO1997003982A11997-02-06
Foreign References:
US6127357A2000-10-03
Other References:
VAN STEEN B J ET AL: "Structure-Affinity Relationship Studies on 5-HT1A receptor Ligands. 2. Heterobicyclic Phenylpiperazines with N4-Aralkyl Substituents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 37, no. 17, 19 August 1994 (1994-08-19), pages 2761 - 2773, XP002055699, ISSN: 0022-2623
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