PIPERAZINYL AND PIPERIDINYL UREAS AS MODULATORS OF FATTY ACID AMIDE HYDROLASE

WIPO Patent Application WO2006074025

B1

Compounds of formula (I) : wherein, Z is -N-or>CH; R¹ is -H or -C_1-4alkyl; Ar¹ is 2-thiazolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-primidinyl, 5-pyrimidinyl, or phenyl, each unsubstituted or substituted at a carbon ring member with one or two R^a moieties; Wher each R^a moiety is independently selected from the group consisting of -C_1-4alkyl, -C_2-4alkenyl, -OH, -OC_1-4alkyl, halo, -CF₃, -OCF₃, -SCF₃, -SH, -S(O)_0-2C_1-4alkyl, -OSO₂C_1-4alkyl, -CO₂C_1-4alkyl, -CO₂H, -COC_1-4alkyl, -N(R^b)R^c, -SO₂NR^bR^c, -NR^bSO₂R^c, -C(=O)NR^bR^c, -NO₂, and -CN, wherein R^b and R^c are each independently -H or -C_1-4alkyl; and Ar² is defined in the claims are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

APODACA RICHARD (US)
BREITENBUCHER J GUY (US)
PATTABIRAMAN KANAKA (US)
SEIERSTAD MARK (US)
XIAO WEI (US)

PCT/US2005/047329

August 31, 2006

December 29, 2005

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JANSSEN PHARMACEUTICA NV (BE)
APODACA RICHARD (US)
BREITENBUCHER J GUY (US)
PATTABIRAMAN KANAKA (US)
SEIERSTAD MARK (US)
XIAO WEI (US)

C07D295/20; A61P25/04; A61P25/22; A61P25/28; C07C275/28; C07D215/12; C07D239/42; C07D241/42; C07D317/58; C07D401/12; C07D405/12; C07D417/12

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