Title:
PIPERIDINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/025233
Kind Code:
A1
Abstract:
Piperidine derivatives of general formula [I] being nonpeptides exhibiting substance P antagonism, or pharmaceutically acceptable acid addition salts thereof; and substance P antagonists containing the derivatives or the salts as the active ingredient, wherein A is a group represented by general formula [A] (wherein m is 0 or 1; n is 1 or 2; X is CH¿2?, O, or CH-CH¿3?; R is optionally substituted phenyl or an optionally substituted heterocyclic group; R¿1? and R¿2? are each independently hydrogen or lower alkyl; and R¿3? is hydrogen or lower alkyl).
Inventors:
BEPPU KOUICHI (JP)
MANAKO TAKAFUMI (JP)
SAKAI MICHINORI (JP)
SAEKI MASAKAZU (JP)
MIZUMA HIDEYUKI (JP)
MANAKO TAKAFUMI (JP)
SAKAI MICHINORI (JP)
SAEKI MASAKAZU (JP)
MIZUMA HIDEYUKI (JP)
Application Number:
PCT/JP2000/006950
Publication Date:
April 12, 2001
Filing Date:
October 05, 2000
Export Citation:
Assignee:
HISAMITSU PHARMACEUTICAL CO (JP)
BEPPU KOUICHI (JP)
MANAKO TAKAFUMI (JP)
SAKAI MICHINORI (JP)
SAEKI MASAKAZU (JP)
MIZUMA HIDEYUKI (JP)
BEPPU KOUICHI (JP)
MANAKO TAKAFUMI (JP)
SAKAI MICHINORI (JP)
SAEKI MASAKAZU (JP)
MIZUMA HIDEYUKI (JP)
International Classes:
A61P1/08; A61P11/06; A61P43/00; C07D405/12; (IPC1-7): C07D405/12; A61K31/443; A61K31/4535; A61K31/454; A61K31/4545; A61P1/08; A61P11/06; A61P43/00; C07D405/14; C07D409/14; C07D413/14; C07D493/04
Domestic Patent References:
| WO1995006645A1 | 1995-03-09 |
Foreign References:
| EP0826684A1 | 1998-03-04 |
Other References:
See also references of EP 1219619A4
Attorney, Agent or Firm:
Murayama, Midori (Yebisu 4-chome Shibuya-ku, Tokyo, JP)
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