PIPERIDYLOXADIAZOLES AS DOPAMINE RECEPTOR ANTAGONISTS

Title:

PIPERIDYLOXADIAZOLES AS DOPAMINE RECEPTOR ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO2000020414

Kind Code:

A9

Abstract:

This invention provides a novel class of oxadiazolyl piperidines which exhibit a high binding affinity for dopamine ligands. The compounds of the invention display selectivity for the dopamine D4 receptor over the dopamine D2 receptor. Preferably, these compounds act as dopamine antagonists, which are useful in the treatment of psychotic disorders.

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Inventors:

WILLIAMS JOHN (US)
LAVRADOR KARINE (US)

Application Number:

PCT/US1999/022972

Publication Date:

August 22, 2002

Filing Date:

September 30, 1999

Export Citation:

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Assignee:

COMBICHEM INC (US)
WILLIAMS JOHN (US)
LAVRADOR KARINE (US)

International Classes:

C07D413/04; C07D413/14; (IPC1-7): C07D413/04; A61K31/41

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