PIPETTE CONFIGURATIONS AND ARRAYS THEREOF FOR MEASURING CELLULAR ELECTRICAL PROPERTIES

WIPO Patent Application WO2003048786

A3

The present application is directed to pipette configurations, arrays of the same and methods for using such pipettes and arrays to accomplish electrical measurements, including whole cell and on cell measurements. In one aspect of the present invention, a pipette (20) includes a hollow tubular section (28) having a distal portion (30) and a tip portion. A bubble (22) is formed at the tip and includes an interior chamber (26) in communication with the hollow tubular section at an end adjacent to the bubble portion. The bubble may have a diameter (D) greater than the diameter of an adjacent portion of the hollow tubular section. An aperture (24) is formed between the internal chamber and an exterior surface (21) of the bubble to accommodate seal formation. In a second aspect of the present invention, a method for forming a glass pipette of the present invention is provided which includes the following steps: (a) heating a glass tube, (b) pulling the glass tube to form a blunt tip, (c) heating the blunt tip, and (d) applying back pressure from the tube to form a bubble including an aperture from the blunt tip.

BULLEN ANDREW (US)
WEAVER CHARLES DAVID (US)

PCT/US2002/038350

March 24, 2005

November 27, 2002

Click for automatic bibliography generation  

BRISTOL MYERS SQUIBB CO (US)
BULLEN ANDREW (US)
WEAVER CHARLES DAVID (US)

B01L3/02; G01N27/28; C12M1/00; C12M1/26; C12Q1/02; C12Q1/24; G01N27/30; G01N27/416; G01N33/487; G01N33/50; (IPC1-7): B01L3/02

US20020144905A1	2002-10-10
US20020064841A1	2002-05-30
US20020063067A1	2002-05-30
US6117291A	2000-09-12
US20020025568A1	2002-02-28
US4022576A	1977-05-10
US3834241A	1974-09-10
US4212204A	1980-07-15
US5406856A	1995-04-18
US4197745A	1980-04-15

See also references of EP 1530505A4

View/Download PDF      PDF Help

Previous Patent: FALLING DETECTION DEVICE

Next Patent: ELECTRODYNAMIC SENSORS AND APPLICATIONS THEREOF