PIRAZINO '1 DOLLAR M(1)2 DOLLAR M(1) :1, 6! PYRIDO '3,4-B! INDOLE DERIVATIVES

Title:

PIRAZINO '1 DOLLAR M(1)2 DOLLAR M(1) :1, 6! PYRIDO '3,4-B! INDOLE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO2002000656

Kind Code:

A3

Abstract:

Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3', 5' monophosphate specific phosphodiesterase (cGMP-specific PDE), in particular PDE5.

Inventors:

ORME MARK W (US)
SAWYER JASON SCOTT (US)
SCHULTZE LISA M (US)
DAUGAN ALAIN CLAUDE-MARIE (FR)
GELLIBERT FRANCOISE (FR)

Application Number:

PCT/US2001/015935

Publication Date:

October 02, 2003

Filing Date:

May 15, 2001

Export Citation:

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Assignee:

LILLY ICOS LLC (US)
ORME MARK W (US)
SAWYER JASON SCOTT (US)
SCHULTZE LISA M (US)
DAUGAN ALAIN CLAUDE-MARIE (FR)
GELLIBERT FRANCOISE (FR)

International Classes:

A61K31/4985; A61K31/5377; A61K31/55; A61P1/00; A61P1/04; A61P1/14; A61P7/02; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; C07D453/02; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P11/16; A61P13/08; A61P13/12; A61P15/00; A61P15/06; A61P15/08; A61P15/10; A61P19/10; A61P27/06; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C07D471/14; C07D519/00; (IPC1-7): C07D471/14; C07D519/00; A61K31/4985; A61P9/00; A61P15/00

Domestic Patent References:

WO1995019978A1

1995-07-27

Other References: