Title:
PKC-ε ACTIVATOR
Document Type and Number:
WIPO Patent Application WO/2012/067111
Kind Code:
A1
Abstract:
The purpose of the present invention is to obtain a DCP-LA enantiomer that exhibits higher activity and is suitable for clinical use and to provide: an agent that contains said enantiomer as an active ingredient and exhibits an excellent PKC-ε activation effect; a prophylactic and/or therapeutic agent for neurotransmitter-release disorders; and a prophylactic and/or therapeutic agent for neuropsychiatric disorders. A compound represented by formula (1) or a pharmacologically permitted salt thereof, and a selective PKC-ε activator containing said compound as an active ingredient.
Inventors:
NISHIZAKI TOMOYUKI (JP)
TANAKA AKITO (JP)
TANAKA AKITO (JP)
Application Number:
PCT/JP2011/076302
Publication Date:
May 24, 2012
Filing Date:
November 15, 2011
Export Citation:
Assignee:
NISHIZAKI BIOINFORMATION RES INST (JP)
NISHIZAKI TOMOYUKI (JP)
TANAKA AKITO (JP)
NISHIZAKI TOMOYUKI (JP)
TANAKA AKITO (JP)
International Classes:
C07C53/132; A61K31/20; A61P1/14; A61P3/02; A61P3/08; A61P5/14; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/24; A61P25/28
Foreign References:
| JP2004516277A | 2004-06-03 | |||
| JP2010202525A | 2010-09-16 | |||
| JP2008143819A | 2008-06-26 |
Other References:
TOMOYUKI NISHIZAKI, SEITAI NO KAGAKU, vol. 60, no. 3, 15 June 2009 (2009-06-15), pages 248 - 255, XP008168690
TAKESHI KANNO ET AL.: "The newly synthesized linoleic acid derivative DCP-LA selectively activates PKC-s", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 45, no. 2, 25 August 2006 (2006-08-25), pages 552, XP008168819
TANAKA ET AL.: "The newly synthesized linoleic acid derivative FR236924 induces a long-Lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 1037 - 1040, XP002550144
KANNO ET AL.: "The linoleic acid derivative DCP-LA selectively activates PKC-s, possibly binding to the phosphatidylserine binding site", JOURNAL OF LIPID RESEARCH, vol. 47, 2006, pages 1146 - 1156, XP002550145
SHIMIZU ET AL.: "alpha,beta-DCP-LA selectively activates PKC-s and stimulates neurotransmitter release with the highest potency among 4 diastereomers", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 27, 3 January 2011 (2011-01-03), pages 149 - 158, XP055088919
TAKESHI KANNO ET AL.: "The newly synthesized linoleic acid derivative DCP-LA selectively activates PKC-s", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 45, no. 2, 25 August 2006 (2006-08-25), pages 552, XP008168819
TANAKA ET AL.: "The newly synthesized linoleic acid derivative FR236924 induces a long-Lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 2003, pages 1037 - 1040, XP002550144
KANNO ET AL.: "The linoleic acid derivative DCP-LA selectively activates PKC-s, possibly binding to the phosphatidylserine binding site", JOURNAL OF LIPID RESEARCH, vol. 47, 2006, pages 1146 - 1156, XP002550145
SHIMIZU ET AL.: "alpha,beta-DCP-LA selectively activates PKC-s and stimulates neurotransmitter release with the highest potency among 4 diastereomers", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 27, 3 January 2011 (2011-01-03), pages 149 - 158, XP055088919
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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