PLANT-DERIVED COMPOSITION FOR VACCINATION AGAINST CLASSICAL SWINE FEVER AND PREPARATION METHOD THEREFOR

Title:

PLANT-DERIVED COMPOSITION FOR VACCINATION AGAINST CLASSICAL SWINE FEVER AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2017/195919

Kind Code:

A1

Abstract:

The present invention relates to a recombinant vector for producing a plant-derived classical swine fever antigen pmE2 protein, a transgenic plant transformed with the recombinant vector, a plant-derived classical swine fever antigen pmE2 protein expressed in the plant, and use thereof. According to the present invention, use may be made of a polynucleotide encoding the GP55 protein of classical swine fever virus; a recombinant vector carrying a polynucleotide coding for a cellulose-binding domain protein; and a transgenic plant transformed with the recombinant vector to produce a plant-derived classical swine fever antigen pmE2 protein at high efficiency, having an advantage in terms of safety and stability over other production methods. In addition, the plant-derived classical swine fever antigen protein pmE2 comprises a cellulose-binding domain (CBD) protein and thus can be usefully utilized as an effective marker for demarcating routes through which classical swine fever virus is exposed and an antibody is produced.

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Inventors:

AN DONG JUN (KR)
LIM SEONG IN (KR)
SONG JAE YOUNG (KR)
JEOUNG HYE YOUNG (KR)
SOHN EUN JU (KR)
HWANG IN HWAN (KR)
PARK NAM JO (KR)
LEE YONG JIK (KR)
KIM NAM HYUNG (KR)
GU SUNG MIN (KR)

Application Number:

PCT/KR2016/005037

Publication Date:

November 16, 2017

Filing Date:

May 12, 2016

Export Citation:

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Assignee:

BIOAPPLICATIONS INC (KR)
REPUBLIC OF KOREA(ANIMAL AND PLANT QUARANTINE AGENCY) (KR)

International Classes:

C12N15/82; A23K20/147; A61K39/12; C07K14/005; G01N33/569

Foreign References:

KR20140073710A	2014-06-17
KR101465231B1	2014-11-26
KR20090038910A	2009-04-21
KR20160077239A	2016-07-04

Other References:

MARCONI ET AL.: "In planta production of two peptides of the Classical Swine Fever Virus (CSFV) E2 glycoprotein fused to the coat protein of potato virus X", BMC BIOTECHNOLOGY, vol. 6, no. 29, 22 June 2006 (2006-06-22), pages 1 - 9, XP002407326, DOI: 10.1186/1472-6750-6-29
DATABASE Nucleotide 21 October 2003 (2003-10-21), "Classical swine fever virus isolated HL-LY E2 mRNA, complete cds", XP055599786, retrieved from NCBI Database accession no. AY430287.1

Attorney, Agent or Firm:

LEE, Myoung-Jin (KR)

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